Laser & Optoelectronics Progress, Volume. 59, Issue 6, 0617006(2022)

Diffusion Correlation Spectroscopy for Tissue Blood Flow Monitoring and Its Clinical Applications

Zhe Li1,2,3、*, Jinchao Feng1,2,3、**, and Kebin Jia1,2,3、***
Author Affiliations
  • 1Faculty of Information Technology, Beijing University of Technology, Beijing 100124, China
  • 2Beijing Laboratory of Advanced Information Networks, Beijing 100124, China
  • 3Beijing Key Laboratory of Computational Intelligence and Intelligent System, Beijing University of Technology, Beijing 100124, China
  • show less
    Figures & Tables(18)
    Schematic of diffusion correlation spectroscopy
    Comparison between tissue blood flow monitoring using fast DCS and traditional DCS[27]. (a) Normalized intensity autocorrelation function; (b) blood flow index
    Schematic of noncontact DCT system with rotational scanning probe[33]
    Calibration method of BFI in skeletal muscle[23]. (a) Experimental protocol; (b) total hemoglobin concentration change; (c) BFI change
    Experimental protocol of the cerebral BFI calibration method[37]
    Network architecture of the BFI quantification method based on LSTM[46]
    Changes of cerebral blood flow (CBF) and cerebrovascular resistance (CVR) in 11 healthy subjects during cerebral autoregulation evaluation[47]
    Changes of cerebral blood flow, mean arterial pressure, intracranial pressure, and cerebral oxygen tension during impaired cerebral autoregulation and intact cerebral autoregulation[48]
    Cerebral blood flow images before and after mechanical thrombectomy and cerebral blood flow monitoring before, during, and after internal carotid artery recanalization[49]
    Time series diagrams of cerebral blood flow under the change of intrathoracic pressure[50]
    Blood flow changes of gastrocnemius muscle tissue obtained by DCS optical probe[17]. (a)-(c) MRI images of gastrocnemius muscle; (d) diagram of DCS optical probe distance; (e) changes of blood flow in gastrocnemius muscle during cuff compression
    Typical muscle hemodynamic responses during bi-femoral artery bypass graft in a patient with peripheral arterial disease(PAD)[51]. (a) rBF in left calf muscle; (b) rBF in right calf muscle
    Comparison results in a PAD patient before and after 3-month exercise training[52]. (a) Changes of tissue blood flow three months ago; (b) changes of tissue blood flow under treadmill exercise load test after three months; (c) box diagram of tissue blood flow changes in exercise group and control group before and after three months
    Changes of gastrocnemius parameters in exercise group and control group of a PAD patient before and after three months[53]. (a) Metabolic rate of oxygen (rMRO2); (b) relative blood flow (rF); (c) tissue oxygen saturation (rStO2)
    Changes of muscle BFI and StO2 during the cycling exercise[54]. (a) Schematic of riding; (b) muscle BFI and StO2 for a representative subject during the cycling exercise
    Tissue blood flow monitoring of neck/head tumor[55-56]. (a) Position diagram of hand-held detection probe; (b) average tumor rBF changes in patients with head and neck cancer after radiotherapy
    Box diagrams of breast tissue blood flow index changes during the neoadjuvant chemotherapy (NAC) treatment[57]. (a) Healthy breast; (b) tumor breast
    • Table 1. Comparison of tissue blood flow monitoring methods[65]

      View table

      Table 1. Comparison of tissue blood flow monitoring methods[65]

      ItemPETSPECTXeCTCT-PDSC-MRIASL-MRIDUDCS
      Age rangeA,CA,CA,CA,CA,CA,C,NA,C,NA,C,N
      BedsideNoSometimesNoNoNoNoYesYes
      Contrast agentYesYesYesYesYesNoNoNo
      RadiationYesYesYesYesNoNoNoNo
      Acquision time5-9 min10-15 min10 min40 s1 min5-10 min1-20 min0.5-6 s
      ParametersCBFCBFCBFMTTMTTCBFBFVCBF
      Large vesselOkOkOkProblemProblemOkONLYMicrovascular
      QuantitativeYesSometimesYesYesN/AYesN/ARelative
      Brain coverageWholeWhole6 cm thick5 cm thickWholeWhole~3/hemisphere~Few/hemisphere
      Spatial resolution~5 mm~5 mm~5 mm~1.5 mm~2 mm~2 mmN/A~10 mm
      Intrascan time10 min10 min20 min10 min25 min0 min0 min0 min
      Emergency settingNoSometimesYesYesYesYesYesYes
      Instrument costHighHighModerateModerateHighHighLowLow
    Tools

    Get Citation

    Copy Citation Text

    Zhe Li, Jinchao Feng, Kebin Jia. Diffusion Correlation Spectroscopy for Tissue Blood Flow Monitoring and Its Clinical Applications[J]. Laser & Optoelectronics Progress, 2022, 59(6): 0617006

    Download Citation

    EndNote(RIS)BibTexPlain Text
    Save article for my favorites
    Paper Information

    Category: Medical Optics and Biotechnology

    Received: Dec. 17, 2021

    Accepted: Jan. 17, 2022

    Published Online: Mar. 8, 2022

    The Author Email: Zhe Li (lizhe1023@bjut.edu.cn), Jinchao Feng (fengjc@bjut.edu.cn), Kebin Jia (kebinj@bjut.edu.cn)

    DOI:10.3788/LOP202259.0617006

    Topics