The fluorescence in vivo wide-field microscopic imaging technology and application in the second near-infrared region

Bu-Jun QUE; Shi-Yi PENG; Wei-Hang GENG; Jian CUI; Sen-Hu HU; Zhe FENG; Jun QIAN

doi:10.11972/j.issn.1001-9014.2022.01.013

Journal of Infrared and Millimeter Waves, Volume. 41, Issue 1, 2021362(2022)

The fluorescence in vivo wide-field microscopic imaging technology and application in the second near-infrared region

Bu-Jun QUE¹, Shi-Yi PENG¹, Wei-Hang GENG¹, Jian CUI², Sen-Hu HU², Zhe FENG¹, and Jun QIAN^1、*

¹State Key Laboratory of Modern Optical Instrumentations，Centre for Optical and Electromagnetic Research，College of Optical Science and Engineering，International Research Center for Advanced Photonics，Zhejiang University，Hangzhou 310058，China

²Ningbo Sunny Instruments Co.，LTD.，Yuyao315400，China

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References(85)

[1] ZHANG M, YUE J, CUI R et al. Bright quantum dots emitting at ∼1,600 nm in the NIR-IIb window for deep tissue fluorescence imaging[J]. Proceedings of the National Academy of Sciences, 115, 6590-5(2018).

[2] ANTARIS A L, CHEN H, CHENG K et al. A small-molecule dye for NIR-II imaging[J]. Nature Materials, 15, 235-42(2016).

[3] WAN H, YUE J, ZHU S et al. A bright organic NIR-II nanofluorophore for three-dimensional imaging into biological tissues[J]. Nature Communications, 9, 1171(2018).

[4] WELSHER K, LIU Z, SHERLOCK S P et al. A route to brightly fluorescent carbon nanotubes for near-infrared imaging in mice[J]. Nature Nanotechnology, 4, 773-80(2009).

[5] YANG Q, MA Z, WANG H et al. Rational Design of Molecular Fluorophores for Biological Imaging in the NIR-II Window[J]. Advanced Materials, 29, 1605497(2017).

[6] ZHANG Y, HONG G, ZHANG Y et al. Ag2S Quantum Dot: A Bright and Biocompatible Fluorescent Nanoprobe in the Second Near-Infrared Window[J]. ACS Nano, 6, 3695-702(2012).

[7] ZHU S, HERRAIZ S, YUE J et al. 3D NIR-II Molecular Imaging Distinguishes Targeted Organs with High-Performance NIR-II Bioconjugates[J]. Advanced Materials, 30, 1705799(2018).

[8] WANG W, MA Z, ZHU S et al. Molecular Cancer Imaging in the Second Near-Infrared Window Using a Renal-Excreted NIR-II Fluorophore-Peptide Probe[J]. Advanced Materials, 30, 1800106(2018).

[9] WAN H, MA H, ZHU S et al. Developing a Bright NIR-II Fluorophore with Fast Renal Excretion and Its Application in Molecular Imaging of Immune Checkpoint PD-L1[J]. Advanced Functional Materials, 28, 1804956(2018).

[10] WANG F, MA Z, ZHONG Y et al. In vivo NIR-II structured-illumination light-sheet microscopy[J]. Proceedings of the National Academy of Sciences, 118, e2023888118(2021).

[11] YANG Z, FAN X, LIU X et al. Aggregation-induced emission fluorophores based on strong electron-acceptor 2,2′-(anthracene-9,10-diylidene) dimalononitrile for biological imaging in the NIR-II window[J]. Chemical Communications, 57, 3099-102(2021).

[12] YANG Z, FAN X, LI H et al. A Small-Molecule Diketopyrrolopyrrole-Based Dye for in vivo NIR-IIa Fluorescence Bioimaging[J]. Chemistry – A European Journal, 27, 14240-9(2021).

[13] WANG W, FENG Z, LI B et al. Er3+ self-sensitized nanoprobes with enhanced 1525 nm downshifting emission for NIR-IIb in vivo bio-imaging[J]. Journal of Materials Chemistry B, 9, 2899-908(2021).

[14] FAN X, LI Y, FENG Z et al. Nanoprobes-Assisted Multichannel NIR-II Fluorescence Imaging-Guided Resection and Photothermal Ablation of Lymph Nodes[J]. Advanced Science, 8, 2003972(2021).

[15] YU X, YING Y, FENG Z et al. Aggregation-induced emission dots assisted non-invasive fluorescence hysterography in near-infrared IIb window[J]. Nano Today, 39, 101235(2021).

[16] BRUNS O T, BISCHOF T S, HARRIS D K et al. Next-generation in vivo optical imaging with short-wave infrared quantum dots[J]. Nature Biomedical Engineering, 1, 0056(2017).

[17] ZHENG Z, JIA Z, QU C et al. Biodegradable Silica-Based Nanotheranostics for Precise MRI/NIR-II Fluorescence Imaging and Self-Reinforcing Antitumor Therapy[J]. Small, 17, 2006508(2021).

[18] ZHANG X, HE S, DING B et al. Cancer cell membrane-coated rare earth doped nanoparticles for tumor surgery navigation in NIR-II imaging window[J]. Chem Eng J, 385, 123959(2020).

[19] SUO Y, WU F, XU P et al. NIR-II Fluorescence Endoscopy for Targeted Imaging of Colorectal Cancer[J]. Advanced Healthcare Materials, 8, 1900974(2019).

[20] LI D, LIU Q, QI Q et al. Gold Nanoclusters for NIR-II Fluorescence Imaging of Bones[J]. Small, 16, 2003851(2020).

[21] SHOU K, QU C, SUN Y et al. Multifunctional Biomedical Imaging in Physiological and Pathological Conditions Using a NIR-II Probe[J]. Advanced Functional Materials, 27, 1700995(2017).

[22] LI D, QU C, LIU Q et al. Monitoring the Real-Time Circulatory System-Related Physiological and Pathological Processes In Vivo Using a Multifunctional NIR-II Probe[J]. Advanced Functional Materials, 30, 1906343(2020).

[23] QU C, XIAO Y, ZHOU H et al. Quaternary Ammonium Salt Based NIR-II Probes for In Vivo Imaging[J]. Advanced Optical Materials, 7, 1900229(2019).

[24] WANG C, FAN W, ZHANG Z et al. Advanced Nanotechnology Leading the Way to Multimodal Imaging-Guided Precision Surgical Therapy[J]. Advanced Materials, 31, 1904329(2019).

[25] ZHU S, YUNG B C, CHANDRA S et al. Near-Infrared-II (NIR-II) Bioimaging via Off-Peak NIR-I Fluorescence Emission[J]. Theranostics, 8, 4141-51(2018).

[26] TIAN R, MA H, ZHU S et al. Multiplexed NIR-II Probes for Lymph Node-Invaded Cancer Detection and Imaging-Guided Surgery[J]. Advanced Materials, 32, 1907365(2020).

[27] TIAN R, ZENG Q, ZHU S et al. Albumin-chaperoned cyanine dye yields superbright NIR-II fluorophore with enhanced pharmacokinetics[J]. Science advances, 5, eaaw0672.

[28] ZHU S, HU Z, TIAN R et al. Repurposing Cyanine NIR-I Dyes Accelerates Clinical Translation of Near-Infrared-II (NIR-II) Bioimaging[J]. Advanced Materials, 30, 1802546(2018).

[29] WANG R, LI X, ZHOU L et al. Epitaxial Seeded Growth of Rare-Earth Nanocrystals with Efficient 800 nm Near-Infrared to 1525 nm Short-Wavelength Infrared Downconversion Photoluminescence for In Vivo Bioimaging[J]. Angewandte Chemie International Edition, 53, 12086-90(2014).

[30] LEI X, LI R, TU D et al. Intense near-infrared-II luminescence from NaCeF4:Er/Yb nanoprobes for in vitro bioassay and in vivo bioimaging[J]. Chemical Science, 9, 4682-8(2018).

[31] LIU L, WANG S, ZHAO B et al. Er3+ Sensitized 1530 nm to 1180 nm Second Near-Infrared Window Upconversion Nanocrystals for In Vivo Biosensing[J]. Angewandte Chemie International Edition, 57, 7518-22(2018).

[32] WANG T, WANG S, LIU Z et al. A hybrid erbium(III)–bacteriochlorin near-infrared probe for multiplexed biomedical imaging[J]. Nature Materials, 20, 1571-8(2021).

[33] FAN Y, WANG P, LU Y et al. Lifetime-engineered NIR-II nanoparticles unlock multiplexed in vivo imaging[J]. Nature Nanotechnology, 13, 941-6(2018).

[34] YANG H, LI R, ZHANG Y et al. Colloidal Alloyed Quantum Dots with Enhanced Photoluminescence Quantum Yield in the NIR-II Window[J]. J Am Chem Soc, 143, 2601-7(2021).

[35] LI C, ZHANG Y, WANG M et al. In vivo real-time visualization of tissue blood flow and angiogenesis using Ag2S quantum dots in the NIR-II window[J]. Biomaterials, 35, 393-400(2014).

[36] LI C, LI F, ZHANG Y et al. Real-Time Monitoring Surface Chemistry-Dependent In Vivo Behaviors of Protein Nanocages via Encapsulating an NIR-II Ag2S Quantum Dot[J]. ACS Nano, 9, 12255-63(2015).

[37] YANG H, HUANG H, MA X et al. Au-Doped Ag2Te Quantum Dots with Bright NIR-IIb Fluorescence for In Situ Monitoring of Angiogenesis and Arteriogenesis in a Hindlimb Ischemic Model[J]. Advanced Materials, 33, 2103953(2021).

[38] ZHANG Y, ZHANG Y, HONG G et al. Biodistribution, pharmacokinetics and toxicology of Ag2S near-infrared quantum dots in mice[J]. Biomaterials, 34, 3639-46(2013).

[39] SUN Y, DING M, ZENG X et al. Novel bright-emission small-molecule NIR-II fluorophores for in vivo tumor imaging and image-guided surgery[J]. Chemical Science, 8, 3489-93(2017).

[40] SUN Y, QU C, CHEN H et al. Novel benzo-bis(1,2,5-thiadiazole) fluorophores for in vivo NIR-II imaging of cancer[J]. Chemical Science, 7, 6203-7(2016).

[41] ZHOU H, ZENG X, LI A et al. Upconversion NIR-II fluorophores for mitochondria-targeted cancer imaging and photothermal therapy[J]. Nature Communications, 11, 6183(2020).

[42] ZHENG Y, LI Q, WU J et al. All-in-one mitochondria-targeted NIR-II fluorophores for cancer therapy and imaging[J]. Chemical Science, 12, 1843-50(2021).

[43] LI J, JIANG R, WANG Q et al. Semiconducting polymer nanotheranostics for NIR-II/Photoacoustic imaging-guided photothermal initiated nitric oxide/photothermal therapy[J]. Biomaterials, 217, 119304(2019).

[44] ZHANG W, SUN X, HUANG T et al. 1300 nm absorption two-acceptor semiconducting polymer nanoparticles for NIR-II photoacoustic imaging system guided NIR-II photothermal therapy[J]. Chemical Communications, 55, 9487-90(2019).

[45] TANG Y, LI Y, WANG Z et al. Organic semiconducting nanoprobe with redox-activatable NIR-II fluorescence for in vivo real-time monitoring of drug toxicity[J]. Chemical Communications, 55, 27-30(2019).

[46] YIN C, LI X, WANG Y et al. Organic Semiconducting Macromolecular Dyes for NIR-II Photoacoustic Imaging and Photothermal Therapy[J]. Advanced Functional Materials, 31, 2104650(2021).

[47] WANG Q, DAI Y, XU J et al. All-in-One Phototheranostics: Single Laser Triggers NIR-II Fluorescence/Photoacoustic Imaging Guided Photothermal/Photodynamic/Chemo Combination Therapy[J]. Advanced Functional Materials, 29, 1901480(2019).

[48] WANG Q, XIA B, XU J et al. Biocompatible small organic molecule phototheranostics for NIR-II fluorescence/photoacoustic imaging and simultaneous photodynamic/photothermal combination therapy[J]. Materials Chemistry Frontiers, 3, 650-5(2019).

[49] HU Z, FANG C, LI B et al. First-in-human liver-tumour surgery guided by multispectral fluorescence imaging in the visible and near-infrared-I/II windows[J]. Nature Biomedical Engineering, 4, 259-71(2020).

[50] MARC P H, DOUGLAS S M. Overview of SWIR detectors, cameras, and applications; proceedings of the ProcSPIE, F, 2008[C].

[51] FENG Z, TANG T, WU T et al. Perfecting and extending the near-infrared imaging window[J]. Light: Science & Applications, 10, 197(2021).

[52] HONG G, DIAO S, CHANG J et al. Through-skull fluorescence imaging of the brain in a new near-infrared window[J]. Nature Photonics, 8, 723-30(2014).

[53] LIAO J, YIN Y, YU J et al. Depth-resolved NIR-II fluorescence mesoscope[J]. Biomed Opt Express, 11, 2366-72(2020).

[54] QI J, SUN C, ZEBIBULA A et al. Real-Time and High-Resolution Bioimaging with Bright Aggregation-Induced Emission Dots in Short-Wave Infrared Region[J]. Advanced Materials, 30, 1706856(2018).

[55] ALIFU N, RONG M, LIJUN Z et al. A Novel TMTP1-modified Theranostic Nanoplatform for Targeted in Vivo NIR-II Fluorescence Imaging-guided Chemotherapy of Cervical Cancer[J]. Research Square(2021). https://doi.org/10.21203/rs.3.rs-818556/v1

[56] NI H, WANG Y, TANG T et al. Quantum Dots assisted In Vivo Two-photon microscopy with NIR-II Emission[J]. Photonics Research(2021). https://doi.org/10.1364/PRJ.441471

[57] FENG Z, YU X, JIANG M et al. Excretable IR-820 for in vivo NIR-II fluorescence cerebrovascular imaging and photothermal therapy of subcutaneous tumor[J]. Theranostics, 9, 5706-19(2019).

[58] YU X, FENG Z, CAI Z et al. Deciphering of cerebrovasculatures via ICG-assisted NIR-II fluorescence microscopy[J]. Journal of Materials Chemistry B, 7, 6623-9(2019).

[59] HE Y, WANG S, YU P et al. NIR-II cell endocytosis-activated fluorescent probes for in vivo high-contrast bioimaging diagnostics[J]. Chemical Science, 12, 10474-82(2021).

[60] ZHAN Y, LING S, HUANG H et al. Rapid Unperturbed-Tissue Analysis for Intraoperative Cancer Diagnosis Using an Enzyme-Activated NIR-II Nanoprobe[J]. Angewandte Chemie International Edition, 60, 2637-42(2021).

[61] FAN X, XIA Q, ZHANG Y et al. Aggregation-Induced Emission (AIE) Nanoparticles-Assisted NIR-II Fluorescence Imaging-Guided Diagnosis and Surgery for Inflammatory Bowel Disease (IBD)[J]. Advanced Healthcare Materials, 2101043(2021).

[62] WEN Q, ZHANG Y, LI C et al. NIR-II Fluorescent Self-Assembled Peptide Nanochain for Ultrasensitive Detection of Peritoneal Metastasis[J]. Angewandte Chemie (International ed in English), 58, 11001-6(2019).

[63] WU D, LIU S, ZHOU J et al. Organic Dots with Large π-Conjugated Planar for Cholangiography beyond 1500 nm in Rabbits: A Non-Radioactive Strategy[J]. ACS Nano, 15, 5011-22(2021).

[64] WU D, XUE D, ZHOU J et al. Extrahepatic cholangiography in near-infrared II window with the clinically approved fluorescence agent indocyanine green: a promising imaging technology for intraoperative diagnosis[J]. Theranostics, 10, 3636-51(2020).

[65] HE M, WU D, ZHANG Y et al. Protein-Enhanced NIR-IIb Emission of Indocyanine Green for Functional Bioimaging[J]. ACS Applied Bio Materials, 3, 9126-34(2020).

[66] LU H, ZOU Q, GU H et al. Rat brains also have a default mode network[J]. Proceedings of the National Academy of Sciences, 109, 3979(2012).

[67] SILVIS S M, DE SOUSA D A, FERRO J M et al. Cerebral venous thrombosis[J]. Nature Reviews Neurology, 13, 555-65(2017).

[68] CAI X, BANDLA A, MAO D et al. Biocompatible Red Fluorescent Organic Nanoparticles with Tunable Size and Aggregation-Induced Emission for Evaluation of Blood–Brain Barrier Damage[J]. Advanced Materials, 28, 8760-5(2016).

[69] SNYDER J S, CHOE J S, CLIFFORD M A et al. Adult-Born Hippocampal Neurons Are More Numerous, Faster Maturing, and More Involved in Behavior in Rats than in Mice[J]. The Journal of Neuroscience, 29, 14484(2009).

[70] QI J, ALIFU N, ZEBIBULA A et al. Highly stable and bright AIE dots for NIR-II deciphering of living rats[J]. Nano Today, 34, 100893(2020).

[71] FENG Z, BAI S, QI J et al. Biologically Excretable Aggregation-Induced Emission Dots for Visualizing Through the Marmosets Intravitally: Horizons in Future Clinical Nanomedicine[J]. Advanced Materials, 33, 2008123(2021).

[72] HUBEL D H, WIESEL T N. Ferrier lecture - Functional architecture of macaque monkey visual cortex[J]. Proceedings of the Royal Society of London Series B Biological Sciences, 198, 1-59(1977).

[73] RAKIC P. Specification of cerebral cortical areas[J]. Science, 241, 170-6(1988).

[74] CAI Z, ZHU L, WANG M et al. NIR-II fluorescence microscopic imaging of cortical vasculature in non-human primates[J]. Theranostics, 10, 4265-76(2020).

[75] SAKADŽIĆ S, MANDEVILLE E T, GAGNON L et al. Large arteriolar component of oxygen delivery implies a safe margin of oxygen supply to cerebral tissue[J]. Nature Communications, 5, 5734(2014).

[76] WEN Q, ZHANG Y, LI C et al. NIR-II Fluorescent Self-Assembled Peptide Nanochain for Ultrasensitive Detection of Peritoneal Metastasis[J]. Angewandte Chemie International Edition, 58, 11001-6(2019).

[77] YANG T, TANG Y A, LIU L et al. Size-Dependent Ag2S Nanodots for Second Near-Infrared Fluorescence/Photoacoustics Imaging and Simultaneous Photothermal Therapy[J]. ACS Nano, 11, 1848-57(2017).

[78] ZHANG M, ZHENG W, LIU Y et al. A New Class of Blue-LED-Excitable NIR-II Luminescent Nanoprobes Based on Lanthanide-Doped CaS Nanoparticles[J]. Angewandte Chemie International Edition, 58, 9556-60(2019).

[79] LI J-B, LIU H-W, FU T et al. Recent Progress in Small-Molecule Near-IR Probes for Bioimaging[J]. Trends in Chemistry, 1, 224-34(2019).

[80] GUO B, FENG Z, HU D et al. Precise Deciphering of Brain Vasculatures and Microscopic Tumors with Dual NIR-II Fluorescence and Photoacoustic Imaging[J]. Advanced Materials, 31, 1902504(2019).

[81] ZHANG Q, ZHOU H, CHEN H et al. Hierarchically Nanostructured Hybrid Platform for Tumor Delineation and Image-Guided Surgery via NIR-II Fluorescence and PET Bimodal Imaging[J]. Small, 15, 1903382(2019).

[82] ZANZONICO P B. Benefits and Risks in Medical Imaging[J]. Health Physics, 116, 135-7(2019).

[83] GRESPAN L, FIORINI P, COLUCCI G[M]. The Route to Patient Safety in Robotic Surgery.

[84] WEISSLEDER R. A clearer vision for in vivo imaging[J]. Nat Biotechnol, 19, 316-7(2001).

[85] LEI X, ZHEN C, HUA Z et al. Preparation and Preliminary Molecular Imaging Study of 124I in-situ Labeled Organic Melanin Nanoparticles[J]. ACTA CHIMICA SINICA, 77, 172-8(2019).

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Bu-Jun QUE, Shi-Yi PENG, Wei-Hang GENG, Jian CUI, Sen-Hu HU, Zhe FENG, Jun QIAN. The fluorescence in vivo wide-field microscopic imaging technology and application in the second near-infrared region[J]. Journal of Infrared and Millimeter Waves, 2022, 41(1): 2021362

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Paper Information

Category: Research Articles

Received: Nov. 8, 2021

Accepted: --

Published Online: Apr. 18, 2022

The Author Email: Jun QIAN (qianjun@zju.edu.cn)

DOI:10.11972/j.issn.1001-9014.2022.01.013

Topics

laser devices and laser physics

Lasers and Laser Optics

Laser physics

laser manufacturing

Instrumentation, Measurement and Metrology