[1] [1] Kaenkumchorn T, Wahbeh G. Ulcerative colitis: making the diagnosis[J]. Gastroenterol Clin North Am, 2020, 49(4): 655-669.

[3] [3] Ciesielska A, Matyjek M, Kwiatkowska K. TLR4 and CD14 trafficking and its influence on LPS-induced pro-inflammatory signaling[J]. Cell Mol Life Sci, 2021, 78(4): 1233-1261.

[4] [4] Zhang Y, Han D, Yu S, et al. Protective effect of iridoid glycosides of the leaves of syringa oblata lindl. on dextran sulfate sodium-induced ulcerative colitis by inhibition of the TLR2/4/MyD88/NF-B signaling pathway[J]. Biomed Res Int, 2020, 2020: 7650123.

[7] [7] Cooper HS, Murthy SN, Shah RS, et al. Clinicopathologic study of dsxtran sulfate sodium experimental murine colitis[J]. Lab Invest, 1993, 69(2): 238-249.

[8] [8] Wan Y, Yang L, Jiang S, et al. Excessive apoptosis in ulcerative colitis: crosstalk between apoptosis, ROS, ER stress, and intestinal homeostasis[J]. Inflamm Bowel Dis, 2022, 28(4): 639-648.

[9] [9] Ma Y, Yin Z, Li L, et al. Food antigens exacerbate intestinal damage and inflammation following the disruption of the mucosal barrier[J]. Int Immunopharmacol, 2021, 96: 107670.

[10] [10] Hsu CC, Okumura R, Motooka D, et al. Alleviation of colonic inflammation by Lypd8 in a mouse model of inflammatory bowel disease[J]. Int Immunol, 2021, 33(7): 359-372.

[11] [11] Qin N, Huang L, Dong R, et al. Polydatin improves intestinal barrier injury after traumatic brain injury in rats by reducing oxidative stress and inflammatory response via activating SIRT1-mediated deacetylation of SOD2 and HMGB1[J]. Nan Fang Yi Ke Da Xue Xue Bao, 2022, 42(1): 93-100.

[12] [12] Ali J, Khan AU, Shah FA, et al. Mucoprotective effects of Saikosaponin-A in 5-fluorouracil-induced intestinal mucositis in mice model[J]. Life Sci, 2019, 239: 116888.

[13] [13] Wang XT, Lu YX, Sun YH, et al. TAK-242 protects against apoptosis in coronary microembolization-induced myocardial injury in rats by suppressing TLR4/NF-B signaling pathway[J]. Cell Physiol Biochem, 2017, 41(4): 1675-1683.

[14] [14] Jiang Z, Zhang J. Mesenchymal stem cell-derived exosomes containing miR-145-5p reduce inflammation in spinal cord injury by regulating the TLR4/NF-B signaling pathway[J]. Cell Cycle, 2021, 20(10): 993-1009.

[15] [15] Wu J, Gan Y, Li M, et al. Patchouli alcohol attenuates 5-fluorouracil-induced intestinal mucositis via TLR2/MyD88/NF-B pathway and regulation of microbiota[J]. Biomed Pharmacother, 2020, 124: 109883.

[16] [16] Lu PD, Zhao YH. Targeting NF-B pathway for treating ulcerative colitis: comprehensive regulatory characteristics of Chinese medicines[J]. Chin Med, 2020, 15: 15.

[17] [17] Liu L, Dong W, Wang S, et al. Deoxycholic acid disrupts the intestinal mucosal barrier and promotes intestinal tumorigenesis[J]. Food Funct, 2018, 9(11): 5588-5597.

[18] [18] An J, Liu Y, Wang Y, et al. The role of intestinal mucosal barrier in autoimmune disease: a potential target[J]. Front Immunol, 2022, 13: 871713.