Acta Laser Biology Sinica, Volume. 34, Issue 2, 107(2025)

Role and Mechanism of Human Glycolipid Transfer Protein in Tumors

ZENG Lu1,2, MA Ziwei1,2, HE Minhui1,2, and ZOU Xianqiong1,2、*
Author Affiliations
  • 1Guilin Medical University Science Experiment Centre, Guilin 541199, China
  • 2Guilin Medical University College of Basic Medical Sciences, Guilin 541199, China
  • show less
    References(37)

    [1] [1] MALININA L, PATEL D J, BROWN R E. How -helical motifs form functionally diverse lipid-binding compartments[J]. Annual Review of Biochemistry, 2017, 86: 609-636.

    [2] [2] MISHRA S K, GAO Y G, ZOU X,et al. Emerging roles for human glycolipid transfer protein superfamily members in the regulation of autophagy, inflammation, and cell death[J]. Progress in Lipid Research, 2020, 78: 101031.

    [3] [3] ZHANG Y, JI S, ZHANG X,et al. HumanCPTPpromotes growth and metastasis via sphingolipid metabolite ceramide and PI4KA/AKT signaling in pancreatic cancer cells[J]. International Journal of Biological Sciences, 2022, 18(13): 4963-4983.

    [4] [4] LI Q, SERIO R J, SCHOFIELD A,et al. Arabidopsis RING-type E3 ubiquitin ligase XBAT35.2 promotes proteasome-dependent degradation of ACD11 to attenuate abiotic stress tolerance[J]. Plant Journal, 2020, 104(6): 1712-1723.

    [5] [5] BACKMAN A P E, HALIN J, NURMI H,et al. Glucosylceramide acyl chain length is sensed by the glycolipid transfer protein[J]. PLoS One, 2018, 13(12): e0209230.

    [6] [6] AL-SHAHERI F N, ALHAMDANI M S S, BAUER A S,et al. Blood biomarkers for differential diagnosis and early detection of pancreatic cancer[J]. Cancer Treatment Reviews, 2021, 96: 102193.

    [7] [7] MALININA L, SIMANSHU D K, ZHAI X,et al. Sphingolipid transfer proteins defined by the GLTP-fold[J]. Quarterly Reviews of Biophysics, 2015, 48(3): 281-322.

    [8] [8] GARCIA-RUIZ C, MORALES A, FERNNDEZ-CHECA J C. Glycosphingolipids and cell death: one aim, many ways[J]. Apoptosis, 2015, 20(5): 607-620.

    [9] [9] NEEFJES J, CABUKUSTA B. What the VAP: the expanded VAP family of proteins interacting with FFAT and FFAT-related motifs for interorganellar contact[J]. Contact (Thousand Oaks), 2021, 4: 25152564211012246.

    [10] [10] SUBRA M, DEZI M, BIGAY J,et al. VAP-A intrinsically disordered regions enable versatile tethering at membrane contact sites[J]. Developmental Cell, 2023, 58(2): 121-138.

    [11] [11] NURMI H, BACKMAN A P E, HALIN J,et al. Glycolipid transfer protein knockout disrupts vesicle trafficking to the plasma membrane[J]. Journal of Biological Chemistry, 2023, 299(4): 104607.

    [12] [12] WANG H, WEI H W, SHEN H C,et al. To study the effect of oxygen carrying capacity on expressed changes of erythrocyte membrane protein in different storage times[J]. Bioscience Reports, 2020, 40(6): BSR20200799.

    [13] [13] ZHANG C, CHEN Z, ZHANG D,et al. Role of Gltp in maturation of oligodendrocytes under the regulation of Nkx2.2[J]. Molecular Neurobiology, 2023, 60(9): 4897-4908.

    [14] [14] YANG F, GUAN Y, FENG X,et al. Proteomics of the corpus callosum to identify novel factors involved in hypomyelinated Niemann-Pick Type C disease mice[J]. Molecular Brain, 2019, 12(1): 17.

    [15] [15] ZHANG H, WESTRM S, KAPPELIN P,et al. Exploration of novel candidate genes involved in epidermal keratinocyte differentiation and skin barrier repair in man[J]. Differentiation, 2021, 119: 19-27.

    [16] [16] SONG B, ZHENG Y, CHI H,et al. Revealing the roles of glycosphingolipid metabolism pathway in the development of keloid: a conjoint analysis of single-cell and machine learning[J]. Frontiers in Immunology, 2023, 14: 1139775.

    [17] [17] SHI Y L, LIU M B, WU H T,et al. GLTP is a potential prognostic biomarker and correlates with immunotherapy efficacy in cervical cancer[J]. Disease Markers, 2022, 2022: 1-14.

    [18] [18] MO J S, PARK Y R, CHAE S C. MicroRNA 196B regulates HOXA5, HOXB6 and GLTP expression levels in colorectal cancer cells[J]. Pathology Oncology Research, 2019, 25(3): 953-959.

    [19] [19] LIU B J, LI F F, XIE Y X,et al. miR-196a upregulation contributes to gefitinib resistance through inhibiting GLTP expression[J]. International Journal of Molecular Sciences, 2022, 23(3): 1785.

    [20] [20] STELZLE D, TANAKA L F, LEE K K,et al. Estimates of the global burden of cervical cancer associated with HIV[J]. Lancet Glob Health, 2021, 9(2): e161-169.

    [21] [21] ZHOU Z, LI W, ZHANG F,et al. The value of squamous cell carcinoma antigen (SCCa) to determine the lymph nodal metastasis in cervical cancer: a meta-analysis and literature review[J]. PLoS One, 2017, 12(12): e0186165.

    [22] [22] SHANG C, HUANG J, GUO H. Identification of an metabolic related risk signature predicts prognosis in cervical cancer and correlates with immune infiltration[J]. Frontiers in Cell and Developmental Biology, 2021, 9: 677831.

    [23] [23] QU X, SHI Z, GUO J,et al. Identification of a novel six-gene signature with potential prognostic and therapeutic value in cervical cancer[J]. Cancer Medicine, 2021, 10(19): 6881-6896.

    [24] [24] WANG S, ZHANG S. A novel eight-gene signature for lipid metabolism predicts the progression of cervical squamous cell carcinoma and endocervical adenocarcinoma[J]. Reproductive Sciences, 2023, 31(2): 514-531.

    [25] [25] XING X, TIAN Y, JIN X. Immune infiltration and a necroptosis-related gene signature for predicting the prognosis of patients with cervical cancer[J]. Frontiers in Genetics, 2022, 13: 1061107.

    [26] [26] CAMP E R, PATTERSON L D, KESTER M,et al. Therapeutic implications of bioactive sphingolipids: a focus on colorectal cancer[J]. Cancer Biology & Therapy, 2017, 18(9): 640-650.

    [27] [27] MISHRA S K, STEPHENSON D J, CHALFANT C E,et al. Upregulation of human glycolipid transfer protein (GLTP) induces necroptosis in colon carcinoma cells[J]. Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids, 2019, 1864(2): 158-167.

    [28] [28] GONG Y, FAN Z, LUO G,et al. The role of necroptosis in cancer biology and therapy[J]. Molecular Cancer, 2019, 18(1): 100.

    [29] [29] WIMAN K G, ZHIVOTOVSKY B. Understanding cell cycle and cell death regulation provides novel weapons against human diseases[J]. Journal of Internal Medicine, 2017, 281(5): 483-495.

    [30] [30] JOHNSTON A, WANG Z. Necroptosis: MLKL polymerization[J]. Journal of Natural Science, 2018, 4(7): e513.

    [31] [31] LIU S, LIU H, JOHNSTON A,et al. MLKL forms disulfide bond-dependent amyloid-like polymers to induce necroptosis[J]. Proceedings of the National Academy of Sciences, United States of America, 2017, 114(36): e7450-7459.

    [32] [32] CHEN X, ZHU R, ZHONG J,et al. Mosaic composition of RIP1-RIP3 signalling hub and its role in regulating cell death[J]. Nature Cell Biology, 2022, 24(4): 471-482.

    [33] [33] SUNG H, FERLAY J, SIEGEL R L,et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J]. CA: A Cancer Journal for Clinicians, 2021, 71(3): 209-249.

    [34] [34] LEVANTINI E, MARONI G, DEL RE M,et al. EGFR signaling pathway as therapeutic target in human cancers[J]. Seminars in Cancer Biology, 2022, 85: 253-275.

    [35] [35] JANKOVIC R, H J G, CAVIC M,et al. LungCARD - report on worldwide research and clinical practices related to lung cancer[J]. Journal of Bone and Oncology, 2019, 24(1): 11-19.

    [36] [36] LAFACE C, MASELLI F M, SANTORO A N,et al. The resistance to EGFR-TKIs in non-small cell lung cancer: from molecular mechanisms to clinical application of new therapeutic strategies[J]. Pharmaceutics, 2023, 15(6): 1640.

    [37] [37] LIARES-BLANCO J, MUNTEANU C R, PAZOS A,et al. Molecular docking and machine learning analysis of Abemaciclib in colon cancer[J]. BMC Molecular Cell Biology, 2020, 21(1): 52.

    Tools

    Get Citation

    Copy Citation Text

    ZENG Lu, MA Ziwei, HE Minhui, ZOU Xianqiong. Role and Mechanism of Human Glycolipid Transfer Protein in Tumors[J]. Acta Laser Biology Sinica, 2025, 34(2): 107

    Download Citation

    EndNote(RIS)BibTexPlain Text
    Save article for my favorites
    Paper Information

    Category:

    Received: Sep. 5, 2024

    Accepted: Jul. 24, 2025

    Published Online: Jul. 24, 2025

    The Author Email: ZOU Xianqiong (zouxq019@glmc.edu.cn)

    DOI:10.3969/j.issn.1007-7146.2025.02.002

    Topics