Acta Laser Biology Sinica, Volume. 34, Issue 3, 267(2025)

Effect of Low Expression of miR-133a on High Glucose-induced Podocyte Inflammatory Apoptosis and Its Related Mechanism

ZHAO Fangfang, TANG Juntao, LIN Yuanyuan, and MA Yilin*
Author Affiliations
  • Endocrine Nephrology Department, Hanzhong People's Hospital, Hanzhong 723000, China
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    References(15)

    [2] [2] COLE J B, FLOREZ J C. Genetics of diabetes mellitus and diabetes complications[J]. Nature Reviews Nephrology, 2020, 16(7): 377-390.

    [3] [3] YE Z, XIAN W, LING G U,et al. Efficacy of danggui buxue decoction on diabetic nephropathy-induced renal fibrosis in rats and possible mechanism[J]. Journal of Traditional Chinese Medicine, 2023, 43(3): 507-513.

    [4] [4] WU T, ZHANG Z Q, HUANG H W,et al. RNA-Seq analysis of ceRNA-related networks in the regulatory metabolic pathway of mice with diabetic nephropathy subjected to empagliflozin intervention[J]. Archivos Espanoles De Urologia, 2023, 76(9): 680-689.

    [5] [5] FOUDI N, LEGEAY S. Effects of physical activity on cell-to-cell communication during type 2 diabetes: a focus on miRNA signaling[J]. Fundamental & Clinical Pharmacology, 2021, 35(5): 808-821.

    [7] [7] DU C Y, ZHANG T, XIAO X,et al. Protease-activated receptor-2 promotes kidney tubular epithelial inflammation by inhibiting autophagy via the PI3K/Akt/mTOR signalling pathway[J]. Biochemical Journal, 2017, 474(16): 2733-2747.

    [8] [8] CHINNADURAI R, CHRYSOCHOU C, KALRA P A. Increased risk for cardiovascular events in patients with diabetic kidney disease and non-alcoholic fatty liver disease[J]. Nephron, 2019, 141(1): 24-30.

    [9] [9] DEMIR S, NAWROTH P P, HERZIG S,et al. Emerging targets in type 2 diabetes and diabetic complications[J]. Advanced Science, 2021, 8(18): e2100275.

    [11] [11] KORSA A T, GENEMO E S, BAYISA H G,et al. Diabetes melitus complications and associated factors amond adult diabetic patients in selected hospitals of West Ethiopia[J]. The Open Cardiovascular Medicine Journal, 2019, 13: 41-48.

    [12] [12] THIPSAWAT S. Early detection of diabetic nephropathy in patient with type 2 diabetes mellitus: a review of the literature[J]. Diabetes & Vascular Disease Research, 2021, 18(6): 1-9.

    [13] [13] EHTEWISH H, ARREDOUANI A, EL-AGNAF O. Diagnostic, prognostic, and mechanistic biomarkers of diabetes mellitus-associated cognitive decline[J]. International Journal of Molecular Sciences, 2022, 23(11): 6144.

    [14] [14] LAI X X, ZHANG N, CHEN L Y,et al. Latifolin protects against myocardial infarction by alleviating myocardial inflammatory via the HIF-1/NF-B/IL-6 pathway[J]. Pharmaceutical Biology, 2020, 58(1): 1156-1166.

    [15] [15] CHANG H Y, CHANG H J, CHENG T J,et al. Micro-ribonucleic acid-23a-3p prevents the onset of type 2 diabetes mellitus by suppressing the activation of nucleotide-binding oligomerization-like receptor family pyrin domain containing 3 inflammatory bodies-caused pyroptosis through negatively regulating NIMA-related kinase 7[J]. Journal of Diabetes Investigation, 2021, 12(3): 334-345.

    [16] [16] AIERKEN A L, LI B L, LIU P,et al. Melatonin treatment improves human umbilical cord mesenchymal stem cell therapy in a mouse model of type II diabetes mellitus via the PI3K/AKT signaling pathway[J]. Stem Cell Research & Therapy, 2022, 13(1): 164.

    [18] [18] WANG F F, LI S, MA L,et al. Study on the mechanism ofPeriplaneta americanaextract to accelerate wound healing after diabetic anal fistula operation based on network pharmacology[J]. Evidence-based Complementary and Alternative Medicine, 2021, 2021: 6659154.

    [19] [19] CHEN S H, LIU X N, PENG Y. MicroRNA-351 eases insulin resistance and liver gluconeogenesis via the PI3K/AKT pathway by inhibiting FLOT2 in mice of gestational diabetes mellitus[J]. Journal of Cellular and Molecular Medicine, 2019, 23(9): 5895-5906.

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    ZHAO Fangfang, TANG Juntao, LIN Yuanyuan, MA Yilin. Effect of Low Expression of miR-133a on High Glucose-induced Podocyte Inflammatory Apoptosis and Its Related Mechanism[J]. Acta Laser Biology Sinica, 2025, 34(3): 267

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    Paper Information

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    Received: Nov. 8, 2024

    Accepted: Jul. 24, 2025

    Published Online: Jul. 24, 2025

    The Author Email: MA Yilin (MYL15291627821@163.com)

    DOI:10.3969/j.issn.1007-7146.2025.03.009

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