Tip-Enhanced Raman Spectroscopy (TERS) technology is a susceptible characterization technique with high spatial resolution. As a non-contact, non-destructive testing system, TERS has gradually become a research hotspot in many disciplines. This paper introduces the principle of TERS technology and the characteristics of metal needle tips, summarizes the research progress of TERS technology in material and life sciences, analyzes the application of TERS technology in teaching, scientific research, and cross-discipline, and discusses the application of TERS technology in chemistry. , physics, biomedicine, and the application of subject teaching and research integration. These research progresses provide essential references for applying TERS technology in material science research, education, and scientific research and help promote further development and application.