International Journal of Digestive Diseases, Volume. 45, Issue 3, 152(2025)

Expression and significance of TRPM8 in the carcinogenesis of ulcerative colitis

BAI Lili1, ZHANG Xinyuan1, ZHANG Xiaolu1, HUA Haixia2, GU Tao1, and FU Yongfeng1、*
Author Affiliations
  • 1Department of Burn and Plastic Surgery, First Hospital of Qinhuangdao, Qinhuangdao 066000, China
  • 1Department of Oncology, First Hospital of Qinhuangdao, Qinhuangdao 066000, China
  • 2Department of Oncology, First Hospital of Qinhuangdao, Qinhuangdao 066000, China
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    References(8)

    [1] [1] Fanizza J, Bencardino S, Allocca M, et al. Inflammatory bowel disease and colorectal cancer[J]. Cancers (Basel), 2024, 16(17): 2943.

    [3] [3] Bopanna S, Ananthakrishnan AN, Kedia S, et al. Risk of colorectal cancer in Asian patients with ulcerative colitis: a systematic review and meta-analysis[J]. Lancet Gastroenterol Hepatol, 2017, 2(4): 269-276.

    [5] [5] Chen L, Xu N, Gou D, et al. TRPM8 overexpression suppresses hepatocellular carcinoma progression and improves survival by modulating the RTP3/STAT3 pathway[J]. Cancer Med, 2024, 13(19): e70109.

    [6] [6] Sheng K, Sang L, Ge H. TRPM8 knockdown relieved inflammatory response and cell apoptosis in pneumonia model induced by Streptococcus pneumoniaein vitro[J]. Cell Mol Biol (Noisy-le-grand), 2023, 69(15): 198-203.

    [11] [11] Shah SC, Itzkowitz SH. Colorectal cancer in inflammatory bowel disease: mechanisms and management[J]. Gastroenterology, 2022, 162(3): 715-730. e3.

    [12] [12] Zhang W, Qiao XY, Li Q, et al. Comprehensive pan-cancer analysis of TRPM8 in tumor metabolism and immune escape[J]. Front Oncol, 2022, 12: 914060.

    [13] [13] Liu JJ, Li LZ, Xu P. Upregulation of TRPM8 can promote the colon cancer liver metastasis through mediating Akt/GSK-3 signal pathway[J]. Biotechnol Appl Biochem, 2022, 69(1): 230-239.

    [14] [14] Kong N, Li W, Zhang J, et al. TRPM8 as a potential biomarker and therapeutic target for gastric cancer identified by a combination of text mining and RNA sequencing[J]. Curr Gene Ther, 2023, 23(5): 391-399.

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    BAI Lili, ZHANG Xinyuan, ZHANG Xiaolu, HUA Haixia, GU Tao, FU Yongfeng. Expression and significance of TRPM8 in the carcinogenesis of ulcerative colitis[J]. International Journal of Digestive Diseases, 2025, 45(3): 152

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    Paper Information

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    Received: Feb. 24, 2025

    Accepted: Aug. 25, 2025

    Published Online: Aug. 25, 2025

    The Author Email: FU Yongfeng (gt529@163.com)

    DOI:10.3969/j.issn.1673-534x.2025.03.005

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