Optics and Precision Engineering, Volume. 33, Issue 8, 1228(2025)

Design and fabrication of microfluidic device used for concentration screening of targeted-drugs

Zhaolin HUO1, Laiqian DING2, Dongfeng QI1, Chong LIU2, and Juan WEI1、*
Author Affiliations
  • 1School of Mechanical Engineering, Shandong University of Technology, Zibo255000, China
  • 2key Laboratory of Micro/nano Technology and System of Liaoning Province, Dalian University of Technology, Dalian116000, China.
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    Figures & Tables(9)
    Design of the CGG based on the equivalent circuit
    Structure of the microfluidic device used for concentration screening of targeted-drugs
    SEM images of cell culture unit and microdam
    Simulation results of velocity and concentration fields in the microfluidic device
    Concentration gradients of fluorescein sodium solution
    Concentration gradients of polystyrene microsphere suspension
    Uniformity and stability analysis of flow field in culture unit
    Growth and folate receptor distribution of Hela and A549 cells cultured in the microfluidic device
    • Table 1. Length of microchannels

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      Table 1. Length of microchannels

      i123
      Ci0.5C00.1C00
      LSi /mm103/
      LBi /mm101010
      LMi /mm3002003
      LB'i /mm5202117
      LOi /mm242.642119
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    Zhaolin HUO, Laiqian DING, Dongfeng QI, Chong LIU, Juan WEI. Design and fabrication of microfluidic device used for concentration screening of targeted-drugs[J]. Optics and Precision Engineering, 2025, 33(8): 1228

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    Paper Information

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    Received: Jan. 10, 2025

    Accepted: --

    Published Online: Jul. 1, 2025

    The Author Email:

    DOI:10.37188/OPE.20253308.1228

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