[1] [1] D. Curtis, A. Hill, A. Wilcock, S. Charlebois, "Foodborne and waterborne pathogenic bacteria in selected Organisation for Economic Cooperation and Development (OECD) countries," J. Food Sci. 79(10), R1871–1876 (2014).

[2] [2] G. Suzzi, A. Corsetti, "Food microbiology: The past and the new challenges for the next 10 Years," Front. Microbiol. 11, 237 (2020).

[3] [3] L. Yang, R. Bashir, "Electrical/electrochemical impedance for rapid detection of foodborne pathogenic bacteria," Biotechnol. Adv. 26(2), 135–150 (2008).

[4] [4] C. Zong, M. Xu, L. J. Xu, T. Wei, X. Ma, X. S. Zheng, R. Hu, B. Ren, "Surface-enhanced Raman spectroscopy for bioanalysis: Reliability and challenges," Chem. Rev. 118(10), 4946–4980 (2018).

[5] [5] A. Campion, P. Kambhampati, "Surface-enhanced Raman scattering," Chem. Soc. Rev. 27(4), 241–250 (1998).

[6] [6] T. T. Bai, M. Wang, M. Cao, J. Zhang, K. Z. Zhang, P. Zhou, Z. X. Liu, Y. Liu, Z. R. Guo, X. Lu, "Functionalized Au@Ag-Au nanoparticles as an optical and SERS dual probe for lateral flow sensing," Anal. Bioanal.Chem. 410(9), 2291–2303 (2018).

[7] [7] W. L. Gao, W. T. Wang, S. H. Yao, S. Wu, H. L. Zhang, J. S. Zhang, F. X. Jing, H. J. Mao, Q. H. Jin, H. Cong, C. P. Jia, G. J. Zhang, J. L. Zhao, "Highly sensitive detection of multiple tumor markers for lung cancer using gold nanoparticle probes and microarrays," Anal. Chim. Acta 958, 77–84 (2017).

[8] [8] Z. Li, L. Leustean, F. Inci, M. Zheng, U. Demirci, S. Wang, "Plasmonic-based platforms for diagnosis of infectious diseases at the point-of-care," Biotechnol. Adv. 37(8), 107440 (2019).

[9] [9] Y. He, X. Wang, B. Ma, J. Xu, "Ramanome technology platform for label-free screening and sorting of microbial cell factories at single-cell resolution," Biotechnol. Adv. 37(6), 107388 (2019).

[10] [10] J. Guo, Z. Zhong, Y. Li, Y. Liu, R. Wang, H. Ju, "Three-in-One" SERS Adhesive Tape for Rapid Sampling, Release, and Detection of Wound Infectious Pathogens," ACS Appl. Mater. Interfaces 11 (40), 36399–36408 (2019).

[11] [11] H. K. Huang, H. W. Cheng, C. C. Liao, S. J. Lin, Y. Z. Chen, J. K. Wang, Y. L. Wang, N. T. Huang, "Bacteria encapsulation and rapid antibiotic susceptibility test using a microfluidic microwell device integrating surface-enhanced Raman scattering," Lab Chip 20(14), 2520–2528 (2020).

[12] [12] H. K. Lee, Y. H. Lee, C. S. L. Koh, G. C. Phan- Quang, X. Han, C. L. Lay, H. Y. F. Sim, Y. C. Kao, Q. An, X. Y. Ling, "Designing surface-enhanced Raman scattering (SERS) platforms beyond hotspot engineering: Emerging opportunities in analyte manipulations and hybrid materials," Chem. Soc. Rev. 48(3), 731–756 (2019).

[13] [13] M. Qiu, A. Singh, D. Wang, J. Qu, M. Swihart, H. Zhang, P. N. Prasad, "Biocompatible and biodegradable inorganic nanostructures for nanomedicine: Silicon and black phosphorus," Nano Today 25, 135–155 (2019).

[14] [14] M. Qiu, W. X. Ren, T. Jeong, M. Won, G. Y. Park, D. K. Sang, L. P. Liu, H. Zhang, J. S. Kim, "Omnipotent phosphorene: A next-generation, twodimensional nanoplatform for multidisciplinary biomedical applications," Chem. Soc. Rev. 47(15), 5588–5601 (2018).

[15] [15] W. Tao, N. Kong, X. Ji, Y. Zhang, A. Sharma, J. Ouyang, B. Qi, J. Wang, N. Xie, C. Kang, H. Zhang, O. C. Farokhzad, J. S. Kim, "Emerging twodimensional monoelemental materials (Xenes) for biomedical applications," Chem. Soc. Rev. 48(11), 2891–2912 (2019).

[16] [16] G. Reina, J. M. Gonzalez-Dominguez, A. Criado, E. Vazquez, A. Bianco, M. Prato, "Promises, facts and challenges for graphene in biomedical applications," Chem. Soc. Rev. 46(15), 4400–4416 (2017).

[17] [17] D. An, J. Fu, Z. Xie, C. Xing, B. Zhang, B. Wang, M. Qiu, "Progress in the therapeutic applications of polymer-decorated black phosphorus and black phosphorus analog nanomaterials in biomedicine," J. Mater. Chem. B (2020).

[18] [18] W. C. Huang, Z. J. Xie, T. J. Fan, J. G. Li, Y. Z. Wang, L. M. Wu, D. T. Ma, Z. J. Li, Y. Q. Ge, Z. Y. N. Huang, X. Y. Dai, Y. J. Xiang, J. Q. Li, X. Zhu, H. Zhang, "Black-phosphorus-analogue tin monosul fide: an emerging optoelectronic two-dimensional material for high-performance photodetection with improved stability under ambient/harsh conditions," J. Mater. Chem. C 6(36), 9582–9593 (2018).

[19] [19] G. Wu, X. Zheng, P. Cui, H. Jiang, X. Wang, Y. Qu, W. Chen, Y. Lin, H. Li, X. Han, Y. Hu, P. Liu, Q. Zhang, J. Ge, Y. Yao, R. Sun, Y. Wu, L. Gu, X. Hong, Y. Li, "A general synthesis approach for amorphous noble metal nanosheets," Nat. Commun. 10 (2019).

[20] [20] W. Zhou, H. Cui, L. Ying, X. F. Yu, "Enhanced cytosolic delivery and release of CRISPR/Cas9 by black phosphorus nanosheets for genome editing," Angew. Chem. Int. Ed. Engl. 57(32), 10268–10272 (2018).

[21] [21] X. Zhu, X. Ji, N. Kong, Y. Chen, M. Mahmoudi, X. Xu, L. Ding, W. Tao, T. Cai, Y. Li, T. Gan, A. Barrett, Z. Bharwani, H. Chen, O. C. Farokhzad, "Intracellular mechanistic understanding of 2D MoS2 nanosheets for anti-exocytosis-enhanced synergistic cancer therapy," ACS Nano 12(3), 2922– 2938 (2018).

[22] [22] M. Qiu, D. Wang, W. Liang, L. Liu, Y. Zhang, X. Chen, D. K. Sang, C. Xing, Z. Li, B. Dong, F. Xing, D. Fan, S. Bao, H. Zhang, Y. Cao, "Novel concept of the smart NIR-light-controlled drug release of black phosphorus nanostructure for cancer therapy," Proc. Natl. Acad. Sci. USA 115(3), 501– 506 (2018).

[23] [23] W. Tao, X. Ji, X. Zhu, L. Li, J. Wang, Y. Zhang, P. E. Saw, W. Li, N. Kong, M. A. Islam, T. Gan, X. Zeng, H. Zhang, M. Mahmoudi, G. J. Tearney, O. C. Farokhzad, "Two-dimensional antimonene-based photonic nanomedicine for cancer theranostics," Adv. Mater. 30(38), e1802061 (2018).

[24] [24] Z. Sun, Y. Zhao, Z. Li, H. Cui, Y. Zhou, W. Li, W. Tao, H. Zhang, H. Wang, P. K. Chu, X. F. Yu, "TiL4-coordinated black phosphorus quantum dots as an efficient contrast agent for in vivo photoacoustic imaging of cancer," Small 13(11), 1602896 (2017).

[25] [25] Y. Li, Z. Liu, Y. Hou, G. Yang, X. Fei, H. Zhao, Y. Guo, C. Su, Z. Wang, H. Zhong, Z. Zhuang, Z. Guo, "Multifunctional nanoplatform based on black phosphorus quantum dots for bioimaging and photodynamic/ photothermal synergistic cancer therapy," ACS Appl. Mater. Interfaces 9(30), 25098–25106 (2017).

[26] [26] H. U. Lee, S. Y. Park, S. C. Lee, S. Choi, S. Seo, H. Kim, J. Won, K. Choi, K. S. Kang, H. G. Park, H. S. Kim, H. R. An, K. H. Jeong, Y. C. Lee, J. Lee, "Black phosphorus (BP) nanodots for potential biomedical applications," Small 12(2), 214–219 (2016).

[27] [27] Q. M. Feng, X. L. Zhao, Y. H. Guo, M. K. Liu, P. Wang, "Stochastic DNA walker for electrochemical biosensing sensitized with gold nanocages@graphene nanoribbons," Biosens. Bioelectron. 108, 97–102 (2018).

[28] [28] Q. Zhao, S. Tang, C. Fang, Y. F. Tu, "Titania nanotubes decorated with gold nanoparticles for electrochemiluminescent biosensing of glycosylated hemoglobin," Anal. Chim. Acta 936, 83–90 (2016).

[29] [29] M. Qiu, Z. T. Sun, D. K. Sang, X. G. Han, H. Zhang, C. M. Niu, "Current progress in black phosphorus materials and their applications in electrochemical energy storage," Nanoscale 9(36), 13384–13403 (2017).

[30] [30] M. Qiu, D. Q. Zhu, X. C. Bao, J. Y. Wang, X. F. Wang, R. Yang, "WO3 with surface oxygen vacancies as an anode buffer layer for high performance polymer solar cells," J. Mater. Chem. A 4(3), 894–900 (2016).

[31] [31] M. Qiu, D. Zhu, L. Yang, N. Wan, L. Han, X. Bao, Z. Du, Y. Niu, R. Yang, "Strategy to manipulate molecular orientation and charge mobility in D-A type conjugated polymer through rational fluorination for improvements of photovoltaic performances," J. Phys. Chem. C 120(40), 22757–22765 (2016).

[32] [32] M. Qiu, R. G. Brandt, Y. Niu, X. Bao, D. Yu, N. Wang, L. Han, L. Yu, S. Xia, R. Yang, "Theoretical study on the rational design of cyanosubstituted P3HT materials for OSCs: Substitution effect on the improvement of photovoltaic performance," J. Phys. Chem. C 119(16), 8501– 8511 (2015).

[33] [33] M. Qiu, S. Long, B. Li, L. Yan, W. Xie, Y. Niu, X. Wang, Q. Guo, A. Xia, "Toward an understanding of how the optical property of water-soluble cationic polythiophene derivative is altered by the addition of salts: The Hofmeister effect," J. Phys. Chem. C 117(42), 21870–21878 (2013).

[34] [34] S. Park, R. S. Ruo?, "Chemical methods for the production of graphenes," Nat. Nanotechnol. 4(4), 217–224 (2009).

[35] [35] W. Wang, H. Bai, H. Y. Li, Q. Lv, Q. Zhang, N. Bao, "Carbon tape coated with gold film as stickers for bulk fabrication of disposable gold electrodes to detect Cr(VI)," Sens. Actuator B-Chem. 236, 218– 225 (2016).

[36] [36] X. F. Gu, X. Li, S. J. Wu, J. Shi, G. Q. Jiang, G. M. Jiang, S. Tian, "A sensitive hydrazine hydrate sensor based on a mercaptomethyl-terminated trinuclear Ni(II) complex modified gold electrode," RSC Adv. 6(10), 8070–8078 (2016).

[37] [37] X. Ling, L. M. Xie, Y. Fang, H. Xu, H. L. Zhang, J. Kong, M. S. Dresselhaus, J. Zhang, Z. F. Liu, "Can graphene be used as a substrate for Raman enhancement?" Nano Lett. 10(2), 553–561 (2010).

[38] [38] J. Lin, L. Liang, X. Ling, S. Zhang, N. Mao, N. Zhang, B. G. Sumpter, V. Meunier, L. Tong, J. Zhang, "Enhanced Raman scattering on in-plane anisotropic layered materials," J. Am. Chem. Soc. 137(49), 15511–15517 (2015).

[39] [39] X. Ling, W. Fang, Y. H. Lee, P. T. Araujo, X. Zhang, J. F. Rodriguez-Nieva, Y. Lin, J. Zhang, J. Kong, M. S. Dresselhaus, "Raman enhancement effect on two-dimensional layered materials: Graphene, h-BN and MoS2," Nano Lett. 14(6), 3033– 3040 (2014).

[40] [40] B. Soundiraraju, B. K. George, "Two-dimensional titanium nitride (Ti2N) MXene: Synthesis, characterization, and potential application as surface-enhanced Raman scattering substrate," ACS Nano 11(9), 8892–8900 (2017).

[41] [41] A. Sarycheva, T. Makaryan, K. Maleski, E. Satheeshkumar, A. Melikyan, H. Minassian, M. Yoshimura, Y. Gogotsi, "Two-dimensional titanium carbide (MXene) as surface-enhanced Raman scattering substrate," J. Phys. Chem. C 121(36), 19983–19988 (2017).

[42] [42] P. Karthick Kannan, P. Shankar, C. Blackman, C.-H. Chung, "Recent advances in 2D inorganic nanomaterials for SERS sensing," Adv. Mater. 31(34), 1803432 (2019).

[43] [43] J. Seo, J. Lee, Y. Kim, D. Koo, G. Lee, H. Park, "Ultrasensitive plasmon-free surface-enhanced Raman spectroscopy with femtomolar detection limit from 2D van der Waals heterostructure," Nano Lett. 20(3), 1620–1630 (2020).

[44] [44] L. Tao, K. Chen, Z. Chen, C. Cong, C. Qiu, J. Chen, X. Wang, H. Chen, T. Yu, W. Xie, S. Deng, J.-B. Xu, "1T0 transition metal telluride atomic layers for plasmon-free SERS at femtomolar levels," J. Am. Chem. Soc. 140(28), 8696–8704 (2018).

[45] [45] Z. J. Xie, C. Y. Xing, W. C. Huang, T. J. Fan, Z. J. Li, J. L. Zhao, Y. J. Xiang, Z. N. Guo, J. Q. Li, Z. G. Yang, B. Q. Dong, J. L. Qu, D. Y. Fan, H. Zhang, "Ultrathin 2D nonlayered tellurium nanosheets: Facile liquid-phase exfoliation, characterization, and photoresponse with high performance and enhanced stability," Adv. Funct. Mater. 28(16), 11 (2018).

[46] [46] Z. Liu, H. Chen, Y. Jia, W. Zhang, H. Zhao,W. Fan, W. Zhang, H. Zhong, Y. Ni, Z. Guo, "A two-dimensional fingerprint nanoprobe based on black phosphorus for bio-SERS analysis and chemo-photothermal therapy," Nanoscale 10(39), 18795– 18804 (2018).

[47] [47] D. Li, H. Yu, Z. Guo, S. Li, Y. Li, Y. Guo, H. Zhong, H. Xiong, Z. Liu, "SERS analysis of carcinoma-associated fibroblasts in a tumor microenvironment based on targeted 2D nanosheets," Nanoscale 12(3), 2133–2141 (2020).

[48] [48] H. Zhao, W. Zhang, Z. Liu, D. Huang, W. Zhang, B. Ye, G. Hu, H. Zhong, Z. Zhuang, Z. Guo, "Insights into the intracellular behaviors of black-phosphorusbased nanocomposites via surface-enhanced Raman spectroscopy," Nanophotonics 7(10), 1651–1662 (2018).

[49] [49] Y. X. Guo, Z. F. Zhuang, Z. M. Liu, W. D. Fan, H. Q. Zhong, W. Zhang, Y. R. Ni, Z. Y. Guo, "Facile hot spots assembly on molybdenum oxide nanosheets via in situ decoration with gold nanoparticles," Appl. Surf. Sci. 480, 1162–1170 (2019).

[50] [50] M. K. Singh, P. Chettri, J. Basu, A. Tripathi, B. Mukherjee, A. Tiwari, R. K. Mandal, "Synthesis of anisotropic Au-Cu alloy nanostructures and its application in SERS for detection of methylene blue," Mater. Res. Express 7(1), 12 (2020).

[51] [51] H. G. Liu, Y. Li, I. I. T. Gilliam, W. W. Shi, N. Chopra, "Surface enhanced Raman scattering (SERS) effect using flexible and selfclosing ZnO nanowire-Au nanoparticle heterostructures," Appl. Surf. Sci. 496, 9 (2019).

[52] [52] W. Ren, Y. Fang, E. Wang, "A Binary functional substrate for enrichment and ultrasensitive SERS spectroscopic detection of folic acid using graphene oxide/Ag nanoparticle hybrids," ACS Nano 5(8), 6425–6433 (2011).

[53] [53] D. D. Galvan, Q. Yu, "Surface-enhanced Raman scattering for rapid detection and characterization of antibiotic-resistant bacteria," Adv. Healthcare Mater. 7(13), e1701335 (2018).

[54] [54] J. Kneipp, H. Kneipp, M. McLaughlin, D. Brown, K. Kneipp, "In vivo molecular probing of cellular compartments with gold nanoparticles and nanoaggregates," Nano Lett. 6(10), 2225–2231 (2006).

[55] [55] K. A. Willets, "Surface-enhanced Raman scattering (SERS) for probing internal cellular structure and dynamics," Anal. Bioanal. Chem. 394(1), 85–94 (2009).