Fig. 1. Filtering algorithm using two-layer long-short-term-memory (LSTM)

Fig. 2. Input information of LSTM for classification

Fig. 3. Measurement paradigm in the simulative experiment

Fig. 4. Three-layer brain-emulating model

Fig. 5. Normalized time-courses of perturbed hemoglobin concentration

Fig. 6. Simulation results. (a) A comparison of absorption perturbation images in CC-layer at the selected time points (colorbar: 0.0001 mm^-1); (b) quantitative comparison of reconstruction at the selected time points; (c) time-courses of average absorption perturbation in the activated region and the corresponding HbO and HbR concentration perturbation

Fig. 7. Source-detector array in the in-vivo experiment

Fig. 8. Measurement paradigm in the in-vivo experiment

Fig. 9. In-vivo experiment results. (a) A comparison of absorption perturbation images in CC-layer at the selected time points; (b) time-courses of average absorption perturbation in the activated region and the corresponding HbO and HbR concentration perturbation

Fig. 10. Simulation results in the presence of time delay of physiological interferences. (a) A comparison of absorption perturbation images in CC-layer at the selected time points (colorbar: 0.0001 mm^-1); (b) quantitative comparison of the reconstruction at the selected time points; (c) time-courses of average absorption perturbation in the activated region and the corresponding HbO and HbR concentration perturbation