Chinese Journal of Cancer Biotherapy, Volume. 32, Issue 7, 698(2025)
2',4'-dihydroxychalcone inhibits the proliferation and migration of colorectal cancer cells by regulating miR-7-5p-induced autophagy
[2] [2] SUNG H, FERLAY J, SIEGEL R L,et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J]. CA Cancer J Clin, 2021, 71(3): 209-249. DOI:10.3322/caac.21660.
[5] [5] LOU C H, WANG M Y, YANG G M,et al. Preliminary studies on anti-tumor activity of 2', 4'-dihydroxychalcone isolated fromHerba Oxytropisin human gastric cancer MGC-803 cells[J]. Toxicol In Vitro, 2009, 23(5): 906-910. DOI:10.1016/j.tiv.2009.05.002.
[6] [6] SHENG Y Q, ZOU M C, WANG Y,et al. 2', 4'-dihydroxychalcone, a flavonoid isolated fromHerba oxytropis, suppresses PC-3 human prostate cancer cell growth by induction of apoptosis[J]. Oncol Lett,2015, 10(6): 3737-3741. DOI:10.3892/ol.2015.3795.
[7] [7] MORALES-MARTNEZ M, VEGA M I. Role of microRNA-7 (MiR-7) in cancer physiopathology[J/OL]. Int J Mol Sci, 2022, 23(16): 9091[2025-01-16]. https://pubmed.ncbi.nlm.nih.gov/36012357/. DOI:10.3390/ijms23169091.
[8] [8] HUANG Y, XIONG Z Y, WANG J J,et al. TBC1D5 reverses the capability of HIF-2 in tumor progression and lipid metabolism in clear cell renal cell carcinoma by regulating the autophagy[J/OL]. J Transl Med, 2024, 22(1): 212[2025-01-16]. https://pubmed.ncbi.nlm.nih.gov/38419050/. DOI:10.1186/s12967-024-05015-y.
[9] [9] LU X L, LIU R Q, LIAO Y Y,et al. ACVRL1 drives resistance to multitarget tyrosine kinase inhibitors in colorectal cancer by promoting USP15-mediated GPX2 stabilization[J/OL]. BMC Med,2023, 21(1): 366[2025-01-16]. https://pubmed.ncbi.nlm.nih.gov/37743483/. DOI:10.1186/s12916-023-03066-4.
[10] [10] SHANG Y Y, ZHU Z, ZHANG Y Y,et al. miR-7-5p/KLF4 signaling inhibits stemness and radioresistance in colorectal cancer[J/OL]. Cell Death Discov, 2023, 9(1): 42[2025-01-16]. https://pubmed.ncbi.nlm.nih.gov/36732504/. DOI:10.1038/s41420-023-01339-8.
[11] [11] LIANG Z Y, LIU L, GAO R X,et al. Downregulation of exosomal miR-7-5p promotes breast cancer migration and invasion by targeting RYK and participating in the atypical WNT signalling pathway[J/OL]. Cell Mol Biol Lett, 2022, 27(1): 88 [2025-01-16]. https://pubmed.ncbi.nlm.nih.gov/36210461/. DOI:10.1186/s11658-022-00393-x.
[12] [12] GHARIB E, REJALI L, PIROOZKHAH M,et al. IL-2RG as a possible immunotherapeutic target in CRC predicting poor prognosis and regulated by miR-7-5p and miR-26b-5p[J/OL]. J Transl Med, 2024, 22(1): 439[2025-01-16]. https://pubmed.ncbi.nlm.nih.gov/38720389/. DOI:10.1186/s12967-024-05251-2.
[13] [13] ZHONG Q Y, LUO Q H, LIN B,et al. Protective effects of andrographolide sodium bisulfate on UV-induced skin carcinogenesis in mice model[J/OL]. Eur J Pharm Sci, 2022, 176: 106232[2025-01-16]. https://pubmed.ncbi.nlm.nih.gov/35710077/. DOI:10.1016/j.ejps.2022.106232.
[14] [14] BROCKMUELLER A, RUIZ DE PORRAS V, SHAKIBAEI M. Curcumin and its anti-colorectal cancer potential: from mechanisms of action to autophagy[J]. Phytother Res, 2024, 38(7): 3525-3551. DOI:10.1002/ptr.8220.
[15] [15] LIU X, WANG J, ZHANG H,et al. CancerMIRNome: an interactive analysis and visualization database for miRNome profiles of human cancer[J/OL]. Nucleic Acids Res, 2022, 50(D1): D1139-D1145[2025-01-16]. https://academic.oup.com/nar/article/50/D1/D1139/6368054. DOI:10.1093/nar/gkab784.
[16] [16] RAMMOHAN A, REDDY J S, SRAVYA G,et al. Chalcone synthesis, properties and medicinal applications: a review[J]. Environ Chem Lett,2020, 18(2): 433-458. DOI:10.1007/s10311-019-00959-w.
[17] [17] YANG M H, BASAPPA B, DEVESHEGOWDA S N,et al. A novel drug prejudice scaffold-imidazopyridine-conjugate can promote cell death in a colorectal cancer model by binding to -catenin and suppressing the Wnt signaling pathway[J]. J Adv Res, 2025, 72:615-632. DOI:10.1016/j.jare.2024.07.022.
[18] [18] SALANCI , VILKOV M, MARTINEZ L,et al. The induction of G2/M phase cell cycle arrest and apoptosis by theChalconederivative 1C in sensitive and resistant ovarian cancer cells is associated with ROS generation[J]. Int J Mol Sci, 2024, 25(14):7541. DOI:10.3390/ijms25147541.
[19] [19] EBBERT L, VON MONTFORT C, WENZEL C K,et al. A combination of cardamonin and doxorubicin selectively affect cell viability of melanoma cells: anin vitrostudy[J/OL]. Antioxidants,2024, 13(7): 864[2025-01-16]. https://pubmed.ncbi.nlm.nih.gov/39061932/. DOI:10.3390/antiox13070864.
[20] [20] YIT C C, DAS N P. Cytotoxic effect of butein on human colon adenocarcinoma cell proliferation[J]. Cancer Lett, 1994, 82(1): 65-72. DOI:10.1016/0304-3835(94)90147-3.
[21] [21] ZHANG C F, WANG K, TAO J H,et al. MYC-dependent miR-7-5p regulated apoptosis and autophagy in diffuse large B cell lymphoma by targeting AMBRA1[J]. Mol Cell Biochem, 2025, 480(1): 191-202. DOI:10.1007/s11010-024-04946-w.
[22] [22] ZHAO S, LIU Y E, WANG J,et al. ADSCs increase the autophagy of chondrocytes through decreasing miR-7-5p in Osteoarthritis rats by targeting ATG4A[J/OL]. Int Immunopharmacol, 2023, 120:110390[2025-01-16]. https://pubmed.ncbi.nlm.nih.gov/37262955/. DOI:10.1016/j.intimp.2023.110390.
[23] [23] MA X L, REN H T, ZHANG Y,et al. LncRNA RHPN1-AS1 inhibition induces autophagy and apoptosis in prostate cancer cellsviathe miR-7-5p/EGFR/PI3K/AKT/mTOR signaling pathway[J]. Environ Toxicol, 2022, 37(12): 3013-3027. DOI:10.1002/tox.23656.
[24] [24] JIN X, JIN W K, TONG L L,et al. Therapeutic strategies of targeting non-apoptotic regulated cell death (RCD) with small-molecule compounds in cancer[J]. Acta Pharm Sin B, 2024, 14(7):2815-2853. DOI:10.1016/j.apsb.2024.04.020.
[25] [25] ZHANG J L, SHANG L, JIANG W D,et al. Shikonin induces apoptosis and autophagyviadownregulation of pyrroline-5-carboxylate reductase1 in hepatocellular carcinoma cells[J]. Bioengineered, 2022,13(3): 7904-7918. DOI:10.1080/21655979.2022.2052673.
[26] [26] LUO D, DAI X Y, TIAN H,et al. Sophflarine A, a novel matrine-derived alkaloid fromSophora flavescenswith therapeutic potential for non-small cell lung cancer through ROS-mediated pyroptosis and autophagy[J/OL]. Phytomedicine, 2023, 116: 154909[2025-01-16]. https://pubmed.ncbi.nlm.nih.gov/37269775/. DOI:10.1016/j. phymed.2023.154909.
[27] [27] MOHAMED L, CHAKRABORTY S, ARULJOTHI K N,et al.Galenia africanaplant extract exhibits cytotoxicity in breast cancer cells by inducing multiple programmed cell death pathways[J]. Saudi Pharm J, 2020, 28(10): 1155-1165. DOI:10.1016/j.jsps.2020.08.004.
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SU Zhaoxia, WANG Nanmiao, CHEN Dan, HAN Youyan, BI Yao, WANG Tong, AN Renbo, PIAO Yingshi, REN Xiangshan, LI Wenjing. 2',4'-dihydroxychalcone inhibits the proliferation and migration of colorectal cancer cells by regulating miR-7-5p-induced autophagy[J]. Chinese Journal of Cancer Biotherapy, 2025, 32(7): 698
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Received: Jan. 18, 2025
Accepted: Aug. 26, 2025
Published Online: Aug. 26, 2025
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