In order to study the fatigue problem of laser melting deposition(LMD) high alloy steel, the fatigue crack growth path and residual life prediction of typical samples were analyzed by the extended finite element method and the direct cyclic. The parameters in Paris formula were obtained by the fatigue experiment of center crack tension(CCT)specimen, and then were used in the finite element simulation. The crack growth process of CCT and compact tension shear samples was studied by the finite element simulation and the experiment respectively. The results indicate that the crack growth path and fatigue life obtained by the finite element simulation are in good agreement with the experiment data. The error of deflection angle of crack propagation path is less than 16.54%, and the error of fatigue life is less than 2.72%. The results show that this method can predict the fatigue crack growth path and fatigue life of LMD high alloy steel components well, which has a certain engineering sense and practice value.