Intelligent Diagnosis of Breast Cancer Based on Polarization and Bright-Field Multimodal Microscopic Imaging

Zhibing Xu; Jinjin Wu; Lu Ding; Zihan Wang; Suwei Zhou; Hui Shang; Huijie Wang; Jianhua Yin

doi:10.3788/CJL202249.2407102

Chinese Journal of Lasers, Volume. 49, Issue 24, 2407102(2022)

Intelligent Diagnosis of Breast Cancer Based on Polarization and Bright-Field Multimodal Microscopic Imaging

Zhibing Xu, Jinjin Wu, Lu Ding, Zihan Wang, Suwei Zhou, Hui Shang, Huijie Wang^*, and Jianhua Yin^**

Department of Biomedical Engineering, College of Automation Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing 211106, Jiangsu, China

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Figures & Tables(6)

Fig. 1. Flow chart of pixel-level fusion of multimodal microscopic images

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Fig. 2. Diagram of cancer diagnosis based on multimodal microscopic imaging

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Fig. 3. Multi-angle polarization microscopic images, bright-field microscopic images and pixel-level fused images of normal and cancerous breast tissues, respectively

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Fig. 4. ROC diagram of classification models based on unimodal and multimodal microscopic imaging

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Table 1. Classification performances of single-angle and multi-angle polarization microscopic imaging

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Table 1. Classification performances of single-angle and multi-angle polarization microscopic imaging

Polarization model	Accuracy	Sensitivity	Specificity	AUC
Polarization 0°	0.7923	0.7513	0.9379	0.9062
Polarization 30°	0.7885	0.7433	0.9453	0.9230
Polarization 60°	0.8115	0.7765	0.9307	0.9138
Polarization fusion	0.8730	0.8688	0.9098	0.9323

Table 2. Classification performances of unimodal and multimodal microscopic imaging
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Table 2. Classification performances of unimodal and multimodal microscopic imaging
Model Accuracy Sensitivity Specificity AUC
Bright-field 0.8540 0.8615 0.8442 0.9013
Polarization 0.8575 0.8592 0.8552 0.9307
Pixel-level 0.8727 0.8737 0.8713 0.9400
Decision-level 0.8710 0.8829 0.8552 0.9367

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Zhibing Xu, Jinjin Wu, Lu Ding, Zihan Wang, Suwei Zhou, Hui Shang, Huijie Wang, Jianhua Yin. Intelligent Diagnosis of Breast Cancer Based on Polarization and Bright-Field Multimodal Microscopic Imaging[J]. Chinese Journal of Lasers, 2022, 49(24): 2407102

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Paper Information

Category: Biomedical Optical Imaging

Received: Aug. 26, 2022

Accepted: Oct. 5, 2022

Published Online: Dec. 19, 2022

The Author Email: Wang Huijie (wanghuijie@nuaa.edu.cn), Yin Jianhua (yin@nuaa.edu.cn)

DOI:10.3788/CJL202249.2407102

Topics

laser devices and laser physics

Lasers and Laser Optics

Laser physics

laser manufacturing

Instrumentation, Measurement and Metrology

Table 1. Classification performances of single-angle and multi-angle polarization microscopic imaging

Table 1. Classification performances of single-angle and multi-angle polarization microscopic imaging

Table 2. Classification performances of unimodal and multimodal microscopic imaging

Table 2. Classification performances of unimodal and multimodal microscopic imaging