Journal of Southeast University (Medical Science Edition), Volume. 44, Issue 3, 473(2025)

Correlation analysis between serum PDK4, NLRP3, PTEN levels and prognosis in patients with sepsis induced myocardial injury

PAN Zhanqun
Author Affiliations
  • Department of Cardiovascular Medicine, the First College of Clinical Medical Science, China Three Gorges University/Yichang Central People's Hospital, Yichang 443003, China
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    References(20)

    [1] [1] FLEISCHMANN C, REICHERT F, CASSINI A, et al. Global incidence and mortality of neonatal sepsis: a systematic review and meta-analysis[J]. Arch Dis Child, 2021, 106(8): 745-752.

    [2] [2] ZHOU B, ZHANG J, CHEN Y, et al. Puerarin protects against sepsis-induced myocardial injury through AMPK-mediated ferroptosis signaling[J]. Aging (Albany NY), 2022, 14(8): 3617-3632.

    [4] [4] BI C F, LIU J, YANG L S, et al. Research progress on the mechanism of sepsis induced myocardial injury[J]. J Inflamm Res, 2022, 15: 4275-4290.

    [5] [5] MA Z, DING Y, DING X, et al. PDK4 rescues high-glucose-induced senescent fibroblasts and promotes diabetic wound healing through enhancing glycolysis and regulating YAP and JNK pathway[J]. Cell Death Discov, 2023, 9(1): 424.

    [6] [6] CHEN T, YE L, ZHU J, et al. Inhibition of pyruvate dehydrogenase kinase 4 attenuates myocardial and mitochondrial injury in sepsis-induced cardiomyopathy[J]. J Infect Dis, 2024, 229(4): 1178-1188.

    [8] [8] DAI S, YE B, CHEN L, et al. Emodin alleviates LPS-induced myocardial injury through inhibition of NLRP3 inflammasome activation[J]. Phytother Res, 2021, 35(9): 5203-5213.

    [9] [9] LIU A, ZHU Y, CHEN W, et al. PTEN dual lipid-and proteinphosphatase function in tumor progression[J]. Cancers (Basel), 2022, 14(15): 3666.

    [10] [10] ZHANG L, LI B, LI W, et al. miR-107 attenuates sepsis-induced myocardial injury by targeting PTEN and activating the PI3K/AKT signaling pathway[J]. Cells Tissues Organs, 2023, 212(6): 523-534.

    [11] [11] SINGER M, DEUTSCHMAN C S, SEYMOUR C W, et al. The third international consensus definitions for sepsis and septic shock (sepsis-3)[J]. JAMA, 2016, 315(8): 801-810.

    [12] [12] BOHNEN J M, MUSTARD R A, OXHOLM S E, et al. APACHE Ⅱ score and abdominal sepsis. A prospective study[J]. Arch Surg, 1988, 123(2): 225-229.

    [13] [13] HOLLENBERG S M, SINGER M. Pathophysiology of sepsisinduced cardiomyopathy[J]. Nat Rev Cardiol, 2021, 18(6): 424-434.

    [14] [14] LIU C, ZOU Q, TANG H, et al. Melanin nanoparticles alleviate sepsis-induced myocardial injury by suppressing ferroptosis and inflammation[J]. Bioact Mater, 2022, 24: 313-321.

    [15] [15] KIM M J, SINAM I S, SIDDIQUE Z, et al. The link between mitochondrial dysfunction and sarcopenia: an update focusing on the role of pyruvate dehydrogenase kinase 4[J]. Diabetes Metab J, 2023, 47(2): 153-163.

    [16] [16] THOUDAM T, CHANDA D, SINAM I S, et al. Noncanonical PDK4 action alters mitochondrial dynamics to affect the cellular respiratory status[J]. Proc Natl Acad Sci U S A, 2022, 119(34): e2120157119.

    [17] [17] LIU B, ZHANG Y, SUO J. Increased expression of PDK4 was displayed in gastric cancer and exhibited an association with glucose metabolism[J]. Front Genet, 2021, 12: 689585.

    [18] [18] DOU X, FU Q, LONG Q, et al. PDK4-dependent hypercatabolism and lactate production of senescent cells promotes cancer malignancy[J]. Nat Metab, 2023, 5(11): 1887-1910.

    [19] [19] ZHENG Y, XU L, DONG N, et al. NLRP3 inflammasome: the rising star in cardiovascular diseases[J]. Front Cardiovasc Med, 2022, 9: 927061.

    [20] [20] HE W, DONG H, WU C, et al. The role of NLRP3 inflammasome in sepsis: a potential therapeutic target[J]. Int Immunopharmacol, 2023, 115: 109697.

    [21] [21] NGUYEN HUU T, PARK J, ZHANG Y, et al. Redox regulation of PTEN by peroxiredoxins[J]. Antioxidants (Basel), 2021, 10(2): 302.

    [22] [22] ZHI D, ZHANG M, LIN J, et al. Role of HMGB1-PTEN signaling in T lymphocytes and monocytes upon sepsis[J]. Clin Lab, 2022, 68(5): DOI: 10.7754/Clin.Lab.2021.211024.

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    PAN Zhanqun. Correlation analysis between serum PDK4, NLRP3, PTEN levels and prognosis in patients with sepsis induced myocardial injury[J]. Journal of Southeast University (Medical Science Edition), 2025, 44(3): 473

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    Paper Information

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    Received: Jan. 15, 2025

    Accepted: Aug. 26, 2025

    Published Online: Aug. 26, 2025

    The Author Email:

    DOI:10.3969/j.issn.1671-6264.2025.03.018

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