Photonic crystal fibers (PCFs) have made a rapid development for the last several years since the first report in 1996. Consequently, all kinds of PCFs with different structures and characteristics have emerged in endlessly. Based on a main thread that the PCFs are used especially to femtosecond laser technologies, a brief overview of the experimental research in this field is presented. Especially the current status and perspective in the high-power/high-energy femtosecond laser systems is highlighted.