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Chinese Journal of Lasers, Volume. 49, Issue 24, 2407101(2022)

Mucosal Lesion Diagnosis System Using Joint Sub-Diffusive Domain Diffuse Reflectance and Fluorescence Spectroscopy

Jie Zheng1, Dongyuan Liu1, Qi Zhang1, Limin Zhang1,2, and Feng Gao1,2、*
Author Affiliations
  • 1College of Precision Instruments and Optoelectronics Engineering, Tianjin University, Tianjin 300072, China
  • 2Tianjin Key Laboratory of Biomedical Detecting Techniques and Instruments, Tianjin 300072, China
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    AbstractGet PDF(in Chinese)
    Figures&Tables (12)
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    References (10)
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    Figures & Tables(12)
    Diagram of light transmission in sub-diffusive domain of mucosal tissue

    Fig. 1. Diagram of light transmission in sub-diffusive domain of mucosal tissue

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    Schematic and physical picture of system. (a) Schematic of system; (b) physical picture

    Fig. 2. Schematic and physical picture of system. (a) Schematic of system; (b) physical picture

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    Schematic of light source module

    Fig. 3. Schematic of light source module

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    MC simulation model and results. (a) MC model with two-layer structure ; (b) ratio of number of photons not reaching Z1 depth to that reaching Z1 depth

    Fig. 4. MC simulation model and results. (a) MC model with two-layer structure ; (b) ratio of number of photons not reaching Z1 depth to that reaching Z1 depth

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    Optical fiber combined probe. (a) Schematic of probe tip; (b) physical picture

    Fig. 5. Optical fiber combined probe. (a) Schematic of probe tip; (b) physical picture

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    Flow chart of system operation

    Fig. 6. Flow chart of system operation

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    Mean spectral intensity and standard deviation of spectral intensity . (a) White LED; (b) ultraviolet LED

    Fig. 7. Mean spectral intensity and standard deviation of spectral intensity . (a) White LED; (b) ultraviolet LED

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    In vitro tissues of four animals. (a) Porcine muscle; (b) chicken breast; (c) pork belly; (d) pork shoulder

    Fig. 8. In vitro tissues of four animals. (a) Porcine muscle; (b) chicken breast; (c) pork belly; (d) pork shoulder

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    Spectral slopes of different tissues at different wavelengths. (a) SDS of 500 μm; (b) SDS of 900 μm

    Fig. 9. Spectral slopes of different tissues at different wavelengths. (a) SDS of 500 μm; (b) SDS of 900 μm

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    Spectra of two mucosal tissues. (a) DRS-500; (b) DRS-900; (c) AFS-500; (d) AFS-900

    Fig. 10. Spectra of two mucosal tissues. (a) DRS-500; (b) DRS-900; (c) AFS-500; (d) AFS-900

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    • Table 1. Classification results of three groups of in vitro tissues in full-band spectra

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      Table 1. Classification results of three groups of in vitro tissues in full-band spectra

      Pretreatment methodClassification accuracy /%
      Porcine muscle and chicken breastPorcine muscle and pork bellyPork belly and pork shoulder
      Smoothing10010082
      Normalization10010070

    • Table 2. Classification results of three groups of in vitro tissues in characteristic band spectra

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      Table 2. Classification results of three groups of in vitro tissues in characteristic band spectra

      Characteristic extraction methodClassification accuracy /%
      Porcine muscle and chicken breastPorcine muscle and pork bellyPork belly and pork shoulder
      First derivative10098.580
      PCA10098.874
      Kurtosis＋skewness＋mean＋variance100100.077
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    Jie Zheng, Dongyuan Liu, Qi Zhang, Limin Zhang, Feng Gao. Mucosal Lesion Diagnosis System Using Joint Sub-Diffusive Domain Diffuse Reflectance and Fluorescence Spectroscopy[J]. Chinese Journal of Lasers, 2022, 49(24): 2407101

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    Paper Information

    Category: Optical Diagnostics and Therapy

    Received: Apr. 11, 2022

    Accepted: May. 16, 2022

    Published Online: Oct. 18, 2022

    The Author Email: Gao Feng (gaofeng@tju.edu.com)

    DOI:10.3788/CJL202249.2407101

    Topics

    laser devices and laser physics
    Lasers and Laser Optics
    Laser physics
    laser manufacturing
    Instrumentation, Measurement and Metrology