Journal of Jiangsu University(Medicine Edition), Volume. 35, Issue 4, 285(2025)

Celastrol induces ferroptosis in rituximab-resistant diffuse large B lymphoma cells by targeting the PI3K/Akt pathway

LIU Xianhai1,2, SUN Xiaolin3, HU Jiabo1, and XU Pei4、*
Author Affiliations
  • 1School of Medicine, Jiangsu University, Zhenjiang Jiangsu 212013
  • 2Department of Clinical Laboratory, Gaoyou People′s Hospital, Gaoyou Jiangsu 225600
  • 3Department of Cardiology, Taizhou People′s Hospital, Taizhou Jiangsu 225300
  • 4Department of Hematopathology, Taizhou People′s Hospital, Taizhou Jiangsu 225300, China
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    References(18)

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    [11] [11] Li X, Liu Z, Cao J, et al. Rituximab in combination with CHOP chemotherapy for the treatment of diffuse large B cell lymphoma in China: a 10-year retrospective follow-up analysis of 437 cases from Shanghai lymphoma research group[J]. Ann Hematol, 2012, 91(6): 837-845.

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    [15] [15] Chen H, He Y, Pan T, et al. Ferroptosis-related gene signature: a new method for personalized risk assessment in patients with diffuse large B-cell lymphoma[J]. Pharmgenomics Pers Med, 2021, 14: 609-619.

    [16] [16] Zhang Y, Tan H, Daniels JD, et al. Imidazole ketone erastin induces ferroptosis and slows tumor growth in a mouse lymphoma model[J]. Cell Chem Biol, 2019, 26(5): 623-633.

    [17] [17] Schmitt A, Xu W, Bucher P, et al. Dimethyl fumarate induces ferroptosis and impairs NF-B/STAT3 signaling in DLBCL[J]. Blood, 2021, 138(10): 871-884.

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    LIU Xianhai, SUN Xiaolin, HU Jiabo, XU Pei. Celastrol induces ferroptosis in rituximab-resistant diffuse large B lymphoma cells by targeting the PI3K/Akt pathway[J]. Journal of Jiangsu University(Medicine Edition), 2025, 35(4): 285

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    Paper Information

    Special Issue:

    Received: May. 10, 2024

    Accepted: Aug. 21, 2025

    Published Online: Aug. 21, 2025

    The Author Email: XU Pei (106938907@qq.com)

    DOI:10.13312/j.issn.1671-7783.y240082

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