Chinese Journal of Lasers, Volume. 47, Issue 1, 0107001(2020)

Single PMT Fluorescence Molecular Tomography Based on Frequency Modulation and Spatial Coding

Ruozhong Chen1, Lin Wang1, Xueli Chen2, Yuqing Hou1、*, and Xiaowei He1
Author Affiliations
  • 1School of Information Technology, Northwest University, Xi'an,Shaanxi 710127, China
  • 2School of Life Science, Xidian University, Xi'an, Shaanxi 710126, China
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    Figures & Tables(9)
    Framework based on frequency modulation and spatial coding detection
    Physical implementation and mathematical modeling of spatially-encoded detection. (a1)(a2)(a3) Physical implementation process; (b1)(b2)(b3) mathematical modeling process
    Mathematical model of physical implementation of frequency modulation and spatial coding detection
    Simulation models. (a) Simple regular geometric model; (b) light source distribution of geometric model; (c) inhomogeneous cylinder model; (d) light source distribution of inhomogeneous cylinder model
    Simulation results of geometric model. (a)-(j) Ten fluorescent images acquired by traditional FMT method; (k)-(t) ten fluorescent images collected by proposed method
    Simulation results of non-homogeneous cylinder model. (a)-(j) Ten fluorescent images acquired by traditional FMT method; (k)-(t) ten fluorescent images collected by proposed method
    • Table 1. Optical parameters for non-homogeneous cylinder phantom

      View table

      Table 1. Optical parameters for non-homogeneous cylinder phantom

      Organμax /mm-1μsx /mm-1μam /mm-1μsm /mm-1
      Muscle0.005210.800.006810.30
      Heart0.00836.730.01046.60
      Lungs0.013319.700.020319.50
      Liver0.03297.000.01766.60
      Bone0.006060.090.003030.74
    • Table 2. Evaluation parameter table of simple regular geometric model

      View table

      Table 2. Evaluation parameter table of simple regular geometric model

      Light source numberPSNR /dBMSESSIM
      124.607.750.96
      225.027.440.96
      321.9010.510.96
      422.779.670.96
      522.329.740.95
      623.069.160.96
      726.167.320.96
      822.519.920.96
      926.306.370.97
      1023.199.200.96
    • Table 3. Evaluation parameter table of non-homogeneous cylinder model

      View table

      Table 3. Evaluation parameter table of non-homogeneous cylinder model

      Light source numberPSNR /dBMSESSIM
      121.6211.130.97
      223.457.350.97
      320.4813.440.96
      420.8512.500.97
      520.0212.820.96
      622.799.170.98
      719.9016.120.95
      824.357.220.98
      920.3015.120.97
      1023.598.540.97
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    Ruozhong Chen, Lin Wang, Xueli Chen, Yuqing Hou, Xiaowei He. Single PMT Fluorescence Molecular Tomography Based on Frequency Modulation and Spatial Coding[J]. Chinese Journal of Lasers, 2020, 47(1): 0107001

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    Paper Information

    Category: biomedical photonics and laser medicine

    Received: Jul. 4, 2019

    Accepted: Sep. 26, 2019

    Published Online: Jan. 9, 2020

    The Author Email: Yuqing Hou (houyuqing@nwu.edu.cn)

    DOI:10.3788/CJL202047.0107001

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