Photonics Research, Volume. 13, Issue 3, 698(2025)

Ultralow-limit of detection optical fiber LSPR biosensor based on a ring laser for des-γ-carboxy prothrombin detection

Xiangshan Li1... Ragini Singh2, Bingyuan Zhang1, Santosh Kumar1,3,4,*, and Guoru Li15,* |Show fewer author(s)
Author Affiliations
  • 1Shandong Key Laboratory of Optical Communication Science and Technology, School of Physics Science and Information Technology, Liaocheng University, Liaocheng 252059, China
  • 2Department of Biotechnology, Koneru Lakshmaiah Education Foundation, Vaddeswaram, Andhra Pradesh 522302, India
  • 3Centre of Excellence for Nanotechnology, Department of Electronics and Communication Engineering, Koneru Lakshmaiah Education Foundation, Vaddeswaram, Andhra Pradesh 522302, India
  • 4e-mail: santosh@kluniversity.in
  • 5e-mail: grli@lcu.edu.cn
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    Figures & Tables(15)
    Schematic diagram of embedded biosensor laser ring cavity system.
    The interference spectrum (black line) obtained using ASE as the light source, and the access laser ring cavity spectrum (red line) obtained with the pump power of 200 mW and OSA resolution of 0.1 nm. Inset, localized increase of FWHM in laser emission spectrum (0.11 nm).
    (a) The laser spectrum of sensors without GNRs varies with RI. (b) The variation of the laser spectrum of sensors with GNRs varies with RI. (c) Comparison of linear fitting. (d) Comparison of SNR and stability.
    The results of the DCP laser fiber sensor: (a) laser emission spectrum, (b) relationship between wavelength and DCP concentration (insert), and between wavelength and logarithm of DCP concentration.
    Sensing performance analysis: (a) repeatability and (b) reproducibility test of fiber probes.
    (a) Selectivity test and (b) pH test of the detection results of DCP fiber probe based on laser ring cavity.
    (a) The temporal variation of laser spectra of a conventional laser ring cavity sensor in DI water. (b) The stability of output power and peak laser wavelength of the partial spectral sequence of an ordinary laser ring cavity sensor. (c) Time variation of laser spectra of GNR laser ring cavity sensors in deionized water. (d) Output power and peak laser wavelength stability of the partial spectral sequence of the GNR laser ring cavity sensor.
    ASE light source test device for feasibility analysis.
    Manufacturing process of W-shaped WaveFlex structure.
    (a) Diameter scan and (b) spectrum analysis of fabricated fiber structures.
    Transmission intensity during fiber optic manufacturing process.
    (a) The ASE spectrum of fiber probes without GNRs and (b) with GNRs varies with RI.
    Schematic diagram of steps for GNRs immobilization and DCP polyclonal antibody functionalization.
    (a) TEM image of GNRs and (b) SEM image of GNRs on the fiber.
    • Table 1. Comparison of the Performance of This Sensor with Other Existing Sensors

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      Table 1. Comparison of the Performance of This Sensor with Other Existing Sensors

      MechanismDetection RangeSensitivityLoDRef.
      New targeted mass spectrometry (MS) determination methodn.r.an.r.a31.72 ng/mL[29]
      Conversion luminescence immunoassay0–2000 ng/mLn.r.a2.66 ng/mL[30]
      Fully automated chemiluminescence immunoassayn.r.an.r.a0.63 ng/mL[31]
      Improved enzyme immunoassay kitn.r.an.r.a10 ng/mL[32]
      W-shaped WaveFlex fiber biosensor based on fiber ring laser0–1000 ng/mL0.265 nm/lg(ng/mL)367.6 pg/mLThis work
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    Xiangshan Li, Ragini Singh, Bingyuan Zhang, Santosh Kumar, Guoru Li, "Ultralow-limit of detection optical fiber LSPR biosensor based on a ring laser for des-γ-carboxy prothrombin detection," Photonics Res. 13, 698 (2025)

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    Paper Information

    Category: Surface Optics and Plasmonics

    Received: Oct. 14, 2024

    Accepted: Dec. 24, 2024

    Published Online: Feb. 27, 2025

    The Author Email: Santosh Kumar (santosh@kluniversity.in), Guoru Li (grli@lcu.edu.cn)

    DOI:10.1364/PRJ.544679

    CSTR:32188.14.PRJ.544679

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