Photonics Research, Volume. 13, Issue 3, 698(2025)
Ultralow-limit of detection optical fiber LSPR biosensor based on a ring laser for des-γ-carboxy prothrombin detection
Fig. 1. Schematic diagram of embedded biosensor laser ring cavity system.
Fig. 2. The interference spectrum (black line) obtained using ASE as the light source, and the access laser ring cavity spectrum (red line) obtained with the pump power of 200 mW and OSA resolution of 0.1 nm. Inset, localized increase of FWHM in laser emission spectrum (0.11 nm).
Fig. 3. (a) The laser spectrum of sensors without GNRs varies with RI. (b) The variation of the laser spectrum of sensors with GNRs varies with RI. (c) Comparison of linear fitting. (d) Comparison of SNR and stability.
Fig. 4. The results of the DCP laser fiber sensor: (a) laser emission spectrum, (b) relationship between wavelength and DCP concentration (insert), and between wavelength and logarithm of DCP concentration.
Fig. 5. Sensing performance analysis: (a) repeatability and (b) reproducibility test of fiber probes.
Fig. 6. (a) Selectivity test and (b) pH test of the detection results of DCP fiber probe based on laser ring cavity.
Fig. 7. (a) The temporal variation of laser spectra of a conventional laser ring cavity sensor in DI water. (b) The stability of output power and peak laser wavelength of the partial spectral sequence of an ordinary laser ring cavity sensor. (c) Time variation of laser spectra of GNR laser ring cavity sensors in deionized water. (d) Output power and peak laser wavelength stability of the partial spectral sequence of the GNR laser ring cavity sensor.
Fig. 10. (a) Diameter scan and (b) spectrum analysis of fabricated fiber structures.
Fig. 11. Transmission intensity during fiber optic manufacturing process.
Fig. 12. (a) The ASE spectrum of fiber probes without GNRs and (b) with GNRs varies with RI.
Fig. 13. Schematic diagram of steps for GNRs immobilization and DCP polyclonal antibody functionalization.
Fig. 14. (a) TEM image of GNRs and (b) SEM image of GNRs on the fiber.
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Xiangshan Li, Ragini Singh, Bingyuan Zhang, Santosh Kumar, Guoru Li, "Ultralow-limit of detection optical fiber LSPR biosensor based on a ring laser for des-γ-carboxy prothrombin detection," Photonics Res. 13, 698 (2025)
Category: Surface Optics and Plasmonics
Received: Oct. 14, 2024
Accepted: Dec. 24, 2024
Published Online: Feb. 27, 2025
The Author Email: Santosh Kumar (santosh@kluniversity.in), Guoru Li (grli@lcu.edu.cn)
CSTR:32188.14.PRJ.544679