Chinese Journal of Lasers, Volume. 47, Issue 10, 1007001(2020)

Photothermal Therapy Method Based on Precise Regulation of Photoacoustic Temperature On the Cover

Ma Yiming1, Ma Liyong1,2, Qin Zezheng1, and Sun Mingjian1,2、*
Author Affiliations
  • 1School of Information Science and Engineering, Harbin Institute of Technology, Weihai, Shandong 264209, China
  • 2School of Astronautics, Harbin Institute of Technology, Harbin, Heilongjiang 150000, China
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    Figures & Tables(19)
    Control block diagram
    Schematic of experimental setup
    Light source of PTT system. (a) Overall optical path; (b) pulse laser; (c) continuous laser
    Integrated probe. (a) Lateral view of the probe; (b) light exit of the probe; (c) 3D model of the integrated probe
    Power control module of the PTT system
    Physical map of experimental phantom. (a) Side view of the phantom; (b) top view of the phantom; (c) the control variable
    Peak-to-peak value of photoacoustic signal of phantoms
    Linear relationship between temperature and photoacoustic signal of each phantom. (a) Control group 1; (b) control group 2; (c) control group 3; (d) control group 4; (e) control group 5; (f) control group 6
    Variation of photoacoustic signal with temperature
    Photoacoustic image of vascular phantom
    Photoacoustic images and sampling signals at different temperatures. (a) Photoacoustic image at 31 ℃; (b) photoacoustic image at 36 ℃; (c) photoacoustic image at 41 ℃; (d) photoacoustic signal at 41 ℃; (e) photoacoustic signal at 36 ℃; (f) photoacoustic signal at 31 ℃
    Distribution curve of intensity values in photoacoustic image matrix
    Linear fitting result between photoacoustic data and actual temperature of phantom. (a) Sensitive point of photoacoustic temperature; (b) average pixel value
    Multimodal reconstruction. (a) Photoacoustic image; (b) ultrasound image; (c) temperature distribution image
    Temperature of human tissue phantom
    Deviation of measured temperature for human tissue phantom
    Temperature measured by thermocouple and photoacoustic method
    • Table 1. Parameters of phantom

      View table

      Table 1. Parameters of phantom

      GroupnumberDeionized waterquality md /gAgar qualityma /gInk qualitymi /g
      010.0350.4030
      110.0150.4020.009
      210.0280.4010.020
      310.0050.4010.040
      410.0110.3990.069
      510.0260.4020.092
      610.0160.4010.126
    • Table 2. Temperature control accuracy of two temperature measurement methods

      View table

      Table 2. Temperature control accuracy of two temperature measurement methods

      MethodMaximumfollowingerror Em /℃Root meansquareerror /℃Adjustmenttime ts /s
      Thermocouple±1.20.946.8
      Photoacoustics±1.10.637.3
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    Ma Yiming, Ma Liyong, Qin Zezheng, Sun Mingjian. Photothermal Therapy Method Based on Precise Regulation of Photoacoustic Temperature[J]. Chinese Journal of Lasers, 2020, 47(10): 1007001

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    Paper Information

    Category: biomedical photonics and laser medicine

    Received: Apr. 2, 2020

    Accepted: --

    Published Online: Oct. 9, 2020

    The Author Email: Mingjian Sun (sunmingjian@hit.edu.cn)

    DOI:10.3788/CJL202047.1007001

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