Acta Laser Biology Sinica, Volume. 34, Issue 3, 207(2025)

Research Progress of 577 nm Subthreshold Micropulse Laser in the Treatment of Retinal Diseases

ZHU Haoyang1, LI Weijia1, FENG Jin2, and ZHOU Dan2、*
Author Affiliations
  • 1Affiliated Hospital of Guangdong Medical University, Zhanjiang 524000, China
  • 2The First Dongguan Affiliated Hospital of Guangdong Medical University, Dongguan 523888, China
  • show less
    References(38)

    [1] [1] MEYER-SCHWICKERATH G R. The history of photocoagulation[J]. Australian and New Zealand Journal of Ophthalmology, 1989, 17(4): 427-434.

    [2] [2] CHHABLANI J, ROH Y J, JOBLING A I,et al. Restorative retinal laser therapy: present state and future directions[J]. Survey of Ophthalmology, 2018, 63(3): 307-328.

    [3] [3] KOZAK I, LUTTRULL J K. Modern retinal laser therapy[J]. Saudi Journal of Ophthalmology: Official Journal of the Saudi Ophthalmological Society, 2015, 29(2): 137-146.

    [4] [4] SUN Z H, HUANG Y, NIE C C,et al. Efficacy and safety of subthreshold micropulse laser compared with threshold conventional laser in central serous chorioretinopathy[J]. Eye, 2020, 34(9): 1592-1599.

    [5] [5] LAVINSKY D, WANG J, HUIE P,et al. Nondamaging retinal laser therapy: rationale and applications to the macula[J]. Investigative Ophthalmology & Visual Science, 2016, 57(6): 2488-2500.

    [6] [6] GAWCKI M. Micropulse laser treatment of retinal diseases[J]. Journal of Clinical Medicine, 2019, 8(2): 242.

    [7] [7] CHANG D B, LUTTRULL J K. Comparison of subthreshold 577 and 810 nm micropulse laser effects on heat-shock protein activation kinetics: implications for treatment efficacy and safety[J]. Translational Vision Science & Technology, 2020, 9(5): 23.

    [8] [8] LUTTRULL J K, DORIN G. Subthreshold diode micropulse laser photocoagulation (SDM) as invisible retinal phototherapy for diabetic macular edema: a review[J]. Current Diabetes Reviews, 2012, 8(4): 274-284.

    [9] [9] FUNG A T, YANG Y, KAM A W. Central serous chorioretinopathy: a review[J]. Clinical and Experimental Ophthalmology, 2023, 51(3): 243-270.

    [10] [10] KOBAT S G, YUSUFOGLU E, GUL F C,et al. Plasma dopamine and catecholamine levels in patients with central serous chorioretinopathy[J]. Journal Francais d′Ophtalmologie, 2021, 44(5): 621-625.

    [11] [11] SUN J H, TAN J F, WANG Z T,et al. Effect of catecholamine on central serous chorioretinopathy[J]. Current Medical Science, 2003, 23: 313-316.

    [12] [12] THOMAS J, ELON H, SUZANNE Y,et al. Central serous chorioretinopathy: towards an evidence-based treatment guideline[J]. Progress in Retinal Research, 2019, 73: 100770.

    [13] [13] SEMERARO F, MORESCALCHI F, RUSSO A,et al. Central serous chorioretinopathy: pathogenesis and management[J]. Clinical Ophthalmology, 2019, 13: 2341-2352.

    [14] [14] DARUICH A, MATET A, DIRANI A,et al. Central serous chorioretinopathy: recent findings and new physiopathology hypothesis[J]. Progress in Retinal and Eye Research, 2015, 48: 82-118.

    [15] [15] IACONO P, POZZO S, VARANO M,et al. Photodynamic therapy with verteporfin for chronic central serous chorioretinopathy: a review of data and efficacy[J]. Pharmaceuticals, 2020, 13(11): 349.

    [17] [17] LI X, LONG H, HU Q H. Efficacy of subthreshold micropulse laser for chronic central serous chorioretinopathy: a meta-analysis[J]. Photodiagnosis and Photodynamic Therapy, 2022, 39: 102931.

    [18] [18] ZHOU L, LAI K, JIN L,et al. Subthreshold micropulse laser vs. conventional laser for central serous chorioretinopathy: a randomized controlled clinical trial[J]. Frontiers in Medicine, 2021, 8: 682264.

    [19] [19] ZHOU L J, HUANG C X, LI Z J,et al. A randomized non-inferiority trial of 577 nm subthreshold micropulse laser versus half-dose photodynamic therapy for acute central serous chorioretinopathy[J]. Photodiagnosis and Photodynamic Therapy, 2024, 45: 103908.

    [20] [20] ROCA J A, WU L, FROMOW-GUERRA J,et al. Yellow (577 nm) micropulse laser versus half-dose verteporfin photodynamic therapy in eyes with chronic central serous chorioretinopathy: results of the Pan-American Collaborative Retina Study (PACORES) Group[J]. British Journal of Ophthalmology, 2018, 102(12): 1696-1700.

    [21] [21] LEE R, WONG T Y, SABANAYAGAM C. Epidemiology of diabetic retinopathy, diabetic macular edema and related vision loss[J]. Eye and Vision, 2015, 2: 17.

    [22] [22] KODJIKIAN L, BELLOCQ D, BANDELLO F,et al. First-line treatment algorithm and guidelines in center-involving diabetic macular edema[J]. European Journal of Ophthalmology, 2019, 29(6): 573-584.

    [23] [23] MADJEDI K, PEREIRA A, BALLIOS B G,et al. Switching between anti-VEGF agents in the management of refractory diabetic macular edema: a systematic review[J]. Survey of Ophthalmology, 2022, 67(5): 1364-1372.

    [25] [25] ALTINEL M G, ACIKALIN B N, ALIS M G,et al. Comparison of the efficacy and safety of anti-VEGF monotherapy versus anti-VEGF therapy combined with subthreshold micropulse laser therapy for diabetic macular edema[J]. Lasers in Medical Science, 2021, 36(7): 1545-1553.

    [26] [26] CITIRIK M. The impact of central foveal thickness on the efficacy of subthreshold micropulse yellow laser photocoagulation in diabetic macular edema[J]. Lasers in Medical Science, 2019, 34(5): 907-912.

    [27] [27] AKKAYA S, AIKALIN B, DOAN Y E,et al. Subthreshold micropulse laser versus intravitreal anti-VEGF for diabetic macular edema patients with relatively better visual acuity[J]. International Journal of Ophthalmology, 2020, 13(10): 1606-1611.

    [28] [28] FRIZZIERO L, CALCIATI A, TORRESIN T,et al. Diabetic macular edema treated with 577-nm subthreshold micropulse laser: a real-life, long-term study[J]. Journal of Personalized Medicine, 2021, 11(5): 405.

    [29] [29] QUERQUES G, QUERQUES L, MARTINELLI D,et al. Pathologic insights from integrated imaging of reticular pseudodrusen in age-related macular degeneration[J]. Retina, 2011, 31(3): 518-526.

    [30] [30] BERENBERG T L, METELITSINA T I, MADOW B,et al. The association between drusen extent and foveolar choroidal blood flow in age-related macular degeneration[J]. Retina, 2012, 32(1): 25-31.

    [31] [31] LUTTRULL J K, SINCLAIR S H, ELMANN S,et al. Low incidence of choroidal neovascularization following subthreshold diode micropulse laser (SDM) in high-risk AMD[J]. PLoS One, 2018, 13(8): e0202097.

    [32] [32] HUANG Z, DENG K Y, DENG Y M,et al. Long-term outcomes of drusenoid pigment epithelium detachment in intermediate AMD treated with 577 nm subthreshold micropulse laser: a preliminary clinical study[J]. International Journal of Ophthalmology, 2022, 15(3): 474-482.

    [34] [34] BUYRU Y, AKKAYA S, AKSOY S,et al. Comparison of ranibizumab and subthreshold micropulse laser in treatment of macular edema secondary to branch retinal vein occlusion[J]. European Journal of Ophthalmology, 2018, 28(6): 690-696.

    [35] [35] TERASHIMA H, HASEBE H, OKAMOTO F,et al. Combination therapy of intravitreal ranibizumab and subthreshold micropulse photocoagulation for macular edema secondary to branch retinal vein occlusion: 6-month result[J]. Retina, 2019, 39(7): 1377-1384.

    [36] [36] LI L, REN Q, SUN Z H,et al. Clinical efficacy of conbercept plus micropulse laser (577 nm) treatment in macular edema secondary to non-ischemic central retinal vein occlusion[J]. Pakistan Journal of Medical Sciences, 2022, 38(5): 1366-1370.

    [37] [37] ENG V A, LENG T. Subthreshold laser therapy for macular oedema from branch retinal vein occlusion: focused review[J]. British Journal of Ophthalmology, 2020, 104(9): 1184-1189.

    [38] [38] LUTTRULL J K. Improved retinal and visual function following panmacular subthreshold diode micropulse laser for retinitis pigmentosa[J]. Eye, 2018, 32(6): 1099-1110.

    [39] [39] KANG Y K, PARK H S. Subthreshold micropulse yellow laser (577 nm) for idiopathic macular telangiectasia type 1 resistant to intravitreal injection[J]. Korean Journal of Ophthalmology, 2020, 34(2): 168-169.

    [40] [40] IOVINO C, IODICE C M, PISANI D,et al. Yellow subthreshold micropulse laser in retinal diseases: an in-depth analysis and review of the literature[J]. Ophthalmology and Therapy, 2023, 12(3): 1479-1500.

    [41] [41] IOVINO C, DI IORIO V, PAOLERCIO L,et al. Navigated 577-nm subthreshold micropulse retinal laser treatment for peripapillary pachychoroid syndrome[J]. American Journal of Ophthalmology Case Reports, 2022, 28: 101757.

    Tools

    Get Citation

    Copy Citation Text

    ZHU Haoyang, LI Weijia, FENG Jin, ZHOU Dan. Research Progress of 577 nm Subthreshold Micropulse Laser in the Treatment of Retinal Diseases[J]. Acta Laser Biology Sinica, 2025, 34(3): 207

    Download Citation

    EndNote(RIS)BibTexPlain Text
    Save article for my favorites
    Paper Information

    Category:

    Received: Jul. 23, 2024

    Accepted: Jul. 24, 2025

    Published Online: Jul. 24, 2025

    The Author Email: ZHOU Dan (zhoudan0108@126.com)

    DOI:10.3969/j.issn.1007-7146.2025.03.002

    Topics