Journal of Southeast University (Medical Science Edition), Volume. 44, Issue 3, 487(2025)

Value of serum AFP and REG4 detection in the diagnosis of endometrial cancer and their relationship with lymph node metastasis

LI Ling1, SONG Yujie1, LI Zhe1, and LUO Lihua2
Author Affiliations
  • 1Department of Obstetrics and Gynecology, Handan Central Hospital, Handan 056000, China
  • 2DepartmentⅡof Gynecology, Shijiazhuang Hospital of Traditional Chinese Medicine, Shijiazhuang 050000, China
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    References(9)

    [5] [5] KONG Y, JING Y, SUN H, et al. The diagnostic value of contrast-enhanced ultrasound and enhanced CT combined with tumor markers AFP and CA199 in liver cancer[J]. J Healthc Eng, 2022, 2022: 5074571.

    [7] [7] ZHANG C Y, ZHANG L, WANG Z M, et al. The bioinformatics analysis of the clinicopathological and prognostic significances of REG4 mRNA in gynecological cancers[J]. J Obstet Gynaecol, 2023, 43(1): 2213764.

    [9] [9] TROJANO G, OLIVIERI C, TINELLI R, et al. Conservative treatment in early stage endometrial cancer: a review[J]. Acta Biomed, 2019, 90(4): 405-410.

    [10] [10] GOWSKA-CIEMNY J, SZYMASKI M, KUSZERSKA A, et al. The role of alpha-fetoprotein (AFP) in contemporary oncology: the path from a diagnostic biomarker to an anticancer drug[J]. Int J Mol Sci, 2023, 24(3): 2539.

    [11] [11] LIN B, DONG X, WANG Q, et al. AFP-inhibiting fragments for drug delivery: the promise and challenges of targeting therapeutics to cancers[J]. Front Cell Dev Biol, 2021, 9: 635476.

    [12] [12] HE H, CHEN S, FAN Z, et al. Multi-dimensional single-cell characterization revealed suppressive immune microenvironment in AFP-positive hepatocellular carcinoma[J]. Cell Discov, 2023, 9(1): 60.

    [17] [17] ZHANG J, ZHU Z, MIAO Z, et al. The clinical significance and mechanisms of REG4 in human cancers[J]. Front Oncol, 2021, 10: 559230.

    [19] [19] GAO L, WU X, ZHANG L, et al. REG4 is a potential biomarker for radiochemotherapy sensitivity in colorectal cancer[J]. Onco Targets Ther, 2021, 14: 1605-1611.

    [20] [20] XIANG L W, XUE H, HA M W, et al. The effects of REG4 expression on chemoresistance of ovarian cancer[J]. J Obstet Gynaecol, 2022, 42(7): 3149-3157.

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    LI Ling, SONG Yujie, LI Zhe, LUO Lihua. Value of serum AFP and REG4 detection in the diagnosis of endometrial cancer and their relationship with lymph node metastasis[J]. Journal of Southeast University (Medical Science Edition), 2025, 44(3): 487

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    Paper Information

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    Received: Jan. 10, 2025

    Accepted: Aug. 26, 2025

    Published Online: Aug. 26, 2025

    The Author Email:

    DOI:10.3969/j.issn.1671-6264.2025.03.020

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