[1] [1] TAN G Y, LIU T G. Rational synthetic pathway refactoring of natural products biosynthesis in actinobacteria［J］. Metabolic Engineering, 2017, 39: 228-236.

[2] [2] DEVINE R, MCDONALD H P, QIN Z, et al. Re-wiring the regulation of the formicamycin biosynthetic gene cluster to enable the development of promising antibacterial compounds［J］. Cell Chemical Biology, 2021, 28(4): 515-523.

[3] [3] WLODEK A, KENDREW S G, COATES N J, et al. Diversity oriented biosynthesis via accelerated evolution of modular gene clusters［J］. Nature Communication, 2017, 8(1): 1206.

[4] [4] RISDIAN C, MOZEF T, WINK J, et al. Biosynthesis of polyketides in Streptomyces［J］. Microorganisms, 2019, 7(5): 124.

[5] [5] DUTTA S, WHICHER J R, HANSEN D A, et al. Structure of a modular polyketide synthase［J］. Nature, 2014, 510(7506): 512-517.

[6] [6] QIAN Z, BRUHN T, DAGOSTINO P M, et al. Discovery of the streptoketides by direct cloning and rapid heterologous expression of a cryptic PKS II gene cluster from Streptomyces sp.Tu 6314 ［J］. Journal of Organic Chemistry, 2020, 85(2): 664-673.

[7] [7] SAKAMOTO S, MORITA Y, YUSAKUL G, et al. Molecular cloning and characterization of type III polyketide synthase from Plumbago zeylanica［J］. Journal of Asian Natural Products Research, 2021, 23(5): 478-490.

[8] [8] FALLAH F, ZARGAR M, YOUSEFI M, et al. Synthesis of the erythromycin-conjugated nanodendrimer and its antibacterial activity［J］. European Journal of Pharmaceutical Sciences, 2018, 123: 321-326.

[9] [9] ZHANG X, CHEN W, GAO Q, et al. Rapamycin directly activates lysosomal mucolipin TRP channels independent of mTOR［J］. PLoS Biology, 2019, 17(5): e3000252.

[10] [10] SONG C, LUAN J, CUI Q, et al. Enhanced heterologous spinosad production from a 79 kb synthetic multi-operon assembly［J］. ACS Synthetic Biology, 2019, 8(1): 137-147.

[11] [11] HUANG J, CHEN A L, ZHANG H, et al. Gene replacement for the generation of designed novel avermectin derivatives with enhanced acaricidal and nematicidal activities［J］. Applied and Environmental Microbiology, 2015, 81(16): 5326-5334.

[12] [12] LE MARECHAL P, DECOTTIGNIES P, MARCHAND C H, et al. Comparative proteomic analysis of Streptomyces lividans wild-type and ppk mutant strains reveals the importance of storage lipids for antibiotic biosynthesis［J］. Applied and Environmental Microbiology, 2013, 79(19): 5907-5917.

[13] [13] ESNAULT C, DULERMO T, SMIRNOV A, et al. Strong antibiotic production is correlated with highly active oxidative metabolism in Streptomyces coelicolor M145［J］. Scientific Reports, 2017, 7(1): 200.

[14] [14] DAVID M, LEJEUNE C, ABREU S, et al. Negative correlation between lipid content and antibiotic activity in Streptomyces: general rule and exceptions［J］. Antibiotics (Basel), 2020, 9(6): 280.

[15] [15] YI J S, YOO H W, KIM E J, et al. Engineering Streptomyces coelicolor for production of monomethyl branched chain fatty acids［J］. Journal of Biotechnology, 2020, 307: 69-76.

[16] [16] HAO Y, YOU Y, CHEN Z, et al. Avermectin B1a production in Streptomyces avermitilis is enhanced by engineering aveC and precursor supply genes［J］. Applied Microbiology and Biotechnology, 2022, 106(56): 2191-2205.

[17] [17] FABIEN C, FRANOISE G, GUILLAUME T, et al. Carbon-flux distribution within Streptomyces coelicolor metabolism: a comparison between the actinorhodin-producing strain M145 and its non-producing derivative M1146［J］. PLoS One, 2013, 8(12): e84151.

[18] [18] MASCHIO L, PARNELL A E, LEES N R, et al. Cloning, expression, and purification of intact polyketide synthase modules［J］. Methods in Enzymology, 2019, 617(63): 63-82.

[19] [19] WU P, CHEN K, LI B, et al. Polyketide starter and extender units serve as regulatory ligands to coordinate the biosynthesis of antibiotics in actinomycetes［J］. Molecular Biosystems, 2021, 12(5): e0229821.

[20] [20] YE J, DEBOSE-BOYD R A. Regulation of cholesterol and fatty acid synthesis［J］. Cold Spring Harbor Perspectives Biology, 2011, 3(7): a004754.

[21] [21] PIETROCOLA F, GALLUZZI L, BRAVO-SAN PEDRO J M, et al. Acetyl coenzyme A: a central metabolite and second messenger［J］. Cell Metabolism, 2015, 21(6): 805-821.

[22] [22] BANCHIO C, GRAMAJO H. A stationary-phase acyl-coenzyme A synthetase of Streptomyces coelicolor A3(2) is necessary for the normal onset of antibiotic production［J］. Applied and Environmental Microbiology, 2002, 68(9): 4240-4246.

[23] [23] TALA A, DAMIANO F, GALLO G, et al. Pirin: a novel redox-sensitive modulator of primary and secondary metabolism in Streptomyces［J］. Metabolic Engineering, 2018, 48: 254-268.

[24] [24] PARSONS J B, MATTHEW W F, CHITRA S, et al. Metabolic basis for the differential susceptibility of Gram-positive pathogens to fatty acid synthesis inhibitors［J］. Proceedings of the National Academy of Sciences, 2011, 108(37): 15378-15383.

[25] [25] HUANG Y, ZHANG X, ZHAO C, et al. Improvement of spinosad production upon utilization of oils and manipulation of beta-oxidation in a high-producing Saccharopolyspora spinosa strain［J］. Journal Molecular Microbiology and Biotechnology, 2018, 28(2): 53-64.

[27] [27] JHA A K, POKHREL A R, CHAUDHARY A K, et al. Metabolic engineering of rational screened Saccharopolyspora spinosa for the enhancement of spinosyns A and D production［J］. Molecules and Cells, 2014, 37(10): 727-733.

[28] [28] TANAKA Y, IZAWA M, HIRAGA Y, et al. Metabolic perturbation to enhance polyketide and nonribosomal peptide antibiotic production using triclosan and ribosome-targeting drugs［J］. Applied Microbiology and Biotechnology, 2017, 101(11): 4417-4431.

[29] [29] VANWEZEL G P, MCDOWALL K J. The regulation of the secondary metabolism of Streptomyces: new links and experimental advances［J］. Natural Product Reports, 2011, 28(7): 1311-1333.

[30] [30] MENZELLA H G, REID R, CARNEY J R, et al. Combinatorial polyketide biosynthesis by de novo design and rearrangement of modular polyketide synthase genes［J］. Nature Biotechnology, 2005, 23(9): 1171-1176.

[31] [31] GAMBOA-SUASNAVART R A, VALDEZ-CRUZ N A, GAYTAN-ORTEGA G, et al. The metabolic switch can be activated in a recombinant strain of Streptomyces lividans by a low oxygen transfer rate in shake flasks［J］. Microbial Cell Factories, 2018, 17(1): 189.

[32] [32] LIU G, CHATER K F, CHANDRA G, et al. Molecular regulation of antibiotic biosynthesis in Streptomyces［J］. Microbiology and Molecular Biology Reviews, 2013, 77(1): 112-43.

[33] [33] RODRIGUEZ E, NAVONE L, CASATI P, et al. Impact of malic enzymes on antibiotic and triacylglycerol production in Streptomyces coelicolor［J］. Applied and Environmental Microbiology, 2012, 78(13): 4571-4579.

[34] [34] ROTTIG A, STRITTMATTER C S, SCHAUER J, et al. Role of wax ester synthase/acyl coenzyme A: diacylglycerol acyltransferase in oleaginous Streptomyces sp. Strain G25［J］. Applied and Environmental Microbiology, 2016, 82(19): 5969-5981.

[35] [35] ZHANG J, LIANG Q, XU Z, et al. The inhibition of antibiotic production in Streptomyces coelicolor over-expressing the TetR regulator SCO3201 is correlated with changes in the lipidome of the strain［J］. Frontiers in Microbiology, 2020, 11: 1399.

[36] [36] WANG W, LI S, LI Z, et al. Harnessing the intracellular triacylglycerols for titer improvement of polyketides in Streptomyces［J］. Nature Biotechnology, 2020, 38(1): 76-83.

[37] [37] LI H, WEI J, DONG J, et al. Enhanced triacylglycerol metabolism contributes to efficient oil utilization and high-level production of salinomycin in Streptomyces albus ZD11［J］. Applied and Environmental Microbiology, 2020, 86(16): e00763-20.

[38] [38] LI S, WANG J, XIANG W, et al. An autoregulated fine-tuning strategy for titer improvement of secondary metabolites using native promoters in Streptomyces［J］. ACS Synthetic Biology, 2018, 7(2): 522-530.

[39] [39] ZHOU Q, NING S, LUO Y, et al. Coordinated regulation for nature products discovery and overproduction in Streptomyces［J］. Synthetic and Systems Biotechnology, 2020, 5(2): 49-58.

[40] [40] WEI J, CHEN B, DONG J, et al. Salinomycin biosynthesis reversely regulates the beta-oxidation pathway in Streptomyces albus by carrying a 3-hydroxyacyl-CoA dehydrogenase gene in its biosynthetic gene cluster［J］. Microbial Biotechnology, 2022, 15(12): 2890-2904.

[41] [41] ALMER C M, MILLER K K, NGUYEN A, et al. Engineering 4-coumaroyl-CoA derived polyketide production in Yarrowia lipolytica through a beta-oxidation mediated strategy［J］. Metabolic Engineering, 2020, 57: 174-181.

[42] [42] MARKHAM K A, PALMER C M, CHWATKO M, et al. Rewiring Yarrowia lipolytica toward triacetic acid lactone for materials generation［J］. Proceedings of the National Academy of Sciences of the United States of America, 2018, 115(9): 2096-2101.

[43] [43] HUANG J, YU Z, LI M H, et al. High level of spinosad production in the heterologous host Saccharopolyspora erythraea［J］. Applied and Environmental Microbiology, 2016, 82(18): 5603-5611.

[44] [44] JIANG H, WANG Y Y, RAN X X, et al. Improvement of natamycin production by engineering of phosphopantetheinyl transferases in Streptomyces chattanoogensis L10［J］. Applied and Environmental Microbiology, 2013, 79(11): 3346-3354.

[45] [45] KUMAR P, DUBEY K K. Modulation of fatty acid metabolism and tricarboxylic acid cycle to enhance the lipstatin production through medium engineering in Streptomyces toxytricini［J］. Bioresource Technology, 2016, 213: 64-68.

[46] [46] VEMURI G N, EITEMAN M A, MCEWEN J E, et al. Increasing NADH oxidation reduces overflow metabolism in Saccharomyces cerevisiae［J］. Proceedings of the National Academy of Sciences of the United States of America, 2007, 104(7): 2402-2407.

[47] [47] LIU H, MARSAFARI M, WANG F, et al. Engineering acetyl-CoA metabolic shortcut for eco-friendly production of polyketides triacetic acid lactone in Yarrowia lipolytica［J］. Metabolic Engineering, 2019, 56: 60-68.

[48] [48] MENENDEZ-BRAVO S, PAGANINI J, AVIGNONE-ROSSA C, et al. Identification of FadAB complexes involved in fatty acid beta-oxidation in Streptomyces coelicolor and construction of a triacylglycerol overproducing strain［J］. Frontiers in Microbiology, 2017, 8: 1428.

[49] [49] HE H, YUAN S, HU J, et al. Effect of the TetR family transcriptional regulator Sp1418 on the global metabolic network of Saccharopolyspora pogona［J］. Microbial Cell Factories, 2020, 19(1): 27.

[50] [50] YANG R, LIU X, WEN Y, et al. The PhoP transcription factor negatively regulates avermectin biosynthesis in Streptomyces avermitilis［J］. Applied Microbiology and Biotechnology, 2015, 99(24): 10547-10557.

[51] [51] LIU C L, HAO R B, BAI Z H, et al. Engineering and manipulation of a mevalonate pathway in Escherichia coli for isoprene production［J］. Applied Microbiology and Biotechnology, 2019, 103(1): 239-250.