Forensic Sciences Research, Volume. 9, Issue 2, owad052(2024)

Forensic features and phylogenetic structure survey of four populations from Southwest China via the autosomal insertion/deletion markers

Han Zhang1,2、†, Meiqing Yang1、†, Hongling Zhang1, Zheng Ren1, Qiyan Wang1, Yubo Liu1, Xiaoye Jin1, Jingyan Ji1, Yuhang Feng1, Changsheng Cai1, Qianchong Ran1, Chengtao Li2、**, and Jiang Huang3、*
Author Affiliations
  • 1Department of Forensic Medicine, Guizhou Medical University, Guiyang, Guizhou, China
  • 2Institute of Forensic Science, Fudan University, Shanghai, China
  • 3The Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Guizhou Medical University, Guiyang, China
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    Figures & Tables(6)
    Combination diagram of insertion allele frequencies and forensic parameters of the 47 A-InDels. (A) Allele frequencies are shown by histogram; (B) Forensic parameters are displayed in the form of a boxplot. Ho: heterozygosity; He: heterozygosity; PM: matching probability; PD: discrimination power; PE: probability of exclusion; PIC: polymorphism information content; TPI: typical paternity index.
    Heatmap of the 47 A-InDels deletion allele frequencies in the four studied populations and other 54 worldwide reference populations. All populations are divided into five groups at the continent level, and all loci are divided into nine clusters based on frequency distribution features.
    Principal component analysis (PCA) between the studied group and worldwide reference populations. (A) PCA plot of 58 populations from five continents constructed on the basis of 47 A-InDels allele frequencies. (B) PCA plot of 37 populations on the scale of East Asia constructed on the basis of allele frequencies. (C, D) PCA based on the genotype data of 46 InDel loci from 49 populations at the individual level.
    The genetic distance and multidimensional scaling between studied groups and reference populations on the continent scale. (A) Pairwise DA genetic distances based on 47 A-InDels allele frequencies for Guizhou Han, Dong, Yi, and Chuanqing, and 54 global reference populations. (B) Pairwise Fst genetic distances based on 46 A-InDels genotype data for the studied groups and other 45 reference populations. (C) MDS plots performed based on the DA genetic distance, including 58 populations. (D) MDS plots performed on the scale of East Asia. MDS: multidimensional scaling.
    Phylogenetic relationships between our studied Guizhou populations and other 54 reference populations based on DA genetic distances, construction of the phylogenetic tree by the neighbour-joining algorithm. The distance scale represents the number of differences between studied taxon and ancestor taxon.
    STRUCTURE analysis at individual level based on the Dataset II of four studied and 45 reference worldwide populations (the optimal K value was 4). Illustration of the ancestry component compositions by using the graphic programme of AncestryPainter. The pie charts were added in the center of the circular graph to highlight the target population.
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    Han Zhang, Meiqing Yang, Hongling Zhang, Zheng Ren, Qiyan Wang, Yubo Liu, Xiaoye Jin, Jingyan Ji, Yuhang Feng, Changsheng Cai, Qianchong Ran, Chengtao Li, Jiang Huang. Forensic features and phylogenetic structure survey of four populations from Southwest China via the autosomal insertion/deletion markers[J]. Forensic Sciences Research, 2024, 9(2): owad052

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    Paper Information

    Category: Research Articles

    Received: Oct. 19, 2022

    Accepted: May. 9, 2023

    Published Online: Sep. 22, 2025

    The Author Email: Chengtao Li (lichengtao@fudan.edu.cn), Jiang Huang (mmm_hj@126.com)

    DOI:10.1093/fsr/owad052

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