Acta Laser Biology Sinica, Volume. 32, Issue 5, 414(2023)
Advances in Optic Nerve Regenerative Repair Signaling Pathways and Gene Editing Therapeutics
[2] [2] PEIXOTO R D S, KRSTIC L, HILL S C L, et al. Predicting quality of life in amd patients-insights on the new nice classification and on a bolt-on vision dimension for the eq-5d[J]. Eye, 2021, 35(12): 3333-3341.
[3] [3] PEREIRA D M, SHAH A, D’SOUZA M, et al. Quality of life in people with diabetic retinopathy: indian study[J]. Journal of Clinical and Diagnostic Research, 2017, 11(4): Nc01-Nc06.
[4] [4] WAUGH N, LOVEMAN E, COLQUITT J, et al. Treatments for dry age-related macular degeneration and stargardt disease: a systematic review[J]. Health Technology Assessment, 2018, 22(27): 1-168.
[5] [5] SABANAYAGAM C, BANU R, CHEE M L, et al. Incidence and progression of diabetic retinopathy: a systematic review[J]. The Lancet Diabetes & Endocrinology, 2019, 7(2): 140-149.
[8] [8] ARCHIBALD N K, CLARKE M P, MOSIMANN U P, et al. The retina in Parkinson’s disease[J]. Brain: A Journal of Neurology, 2009, 132(5): 1128-1145.
[9] [9] BODIS-WOLLNER I. Retinopathy in Parkinson disease[J]. Journal of Neural Transmission, 2009, 116(11): 1493-1501.
[12] [12] CAMERON D A, GENTILE K L, MIDDLETON F A, et al. Gene expression profiles of intact and regenerating zebrafish retina[J]. Molecular Vision, 2005, 11: 775-791.
[13] [13] FAILLACE M P, JULIAN D, KORENBROT J I. Mitotic activation of proliferative cells in the inner nuclear layer of the mature fish retina: regulatory signals and molecular markers[J]. Journal of Comparative Neurology, 2002, 451(2): 127-141.
[14] [14] WU D M, SCHNEIDERMAN T, BURGETT J, et al. Cones regenerate from retinal stem cells sequestered in the inner nuclear layer of adult goldfish retina[J]. Investigative Ophthalmology & Visual science, 2001, 42(9): 2115-2124.
[15] [15] BRINGMANN A, IANDIEV I, PANNICKE T, et al. Cellular signaling and factors involved in Müller cell gliosis: neuroprotective and detrimental effects[J]. Progress in Retinal and Eye Research, 2009, 28(6): 423-451.
[16] [16] GHAI K, ZELINKA C, FISCHER A J. Notch signaling influences neuroprotective and proliferative properties of mature Müller glia[J]. Journal of Neuroscience, 2010, 30(8): 3101-3112.
[17] [17] FISCHER A J, REH T A. Müller glia are a potential source of neural regeneration in the postnatal chicken retina[J]. Nature Neuroscience, 2001, 4(3): 247-252.
[18] [18] HAYES S, NELSON B R, BUCKINGHAM B, et al. Notch signaling regulates regeneration in the avian retina[J]. Developmental Biology, 2007, 312(1): 300-311.
[19] [19] FISCHER A J. Neural regeneration in the chick retina[J]. Progress in Retinal and Eye Research, 2005, 24(2): 161-182.
[20] [20] DYER M A, CEPKO C L. Control of Müller glial cell proliferation and activation following retinal injury[J]. Nature Neuroscience, 2000, 3(9): 873-880.
[31] [31] PEARSON R A, BARBER A C, WEST E L, et al. Targeted disruption of outer limiting membrane junctional proteins (crb1 and zo-1) increases integration of transplanted photoreceptor precursors into the adult wild-type and degenerating retina[J]. Cell Transplant, 2010, 19(4): 487-503.
[32] [32] BECK T, NUGLISCH J, SAUER D, et al. Effects of flunarizine on postischemic blood flow, energy metabolism and neuronal damage in the rat brain[J]. European Journal of Pharmacology, 1988, 158(3): 271-274.
[34] [34] EGGENBERGER S C, JAMES N L, HO C, et al. Implantation and long-term assessment of the stability and biocompatibility of a novel 98 channel suprachoroidal visual prosthesis in sheep[J]. Biomaterials, 2021, 279: 121191.
[35] [35] SCHWARTZ S D, HUBSCHMAN J P, HEILWELL G, et al. Embryonic stem cell trials for macular degeneration: a preliminary report[J]. Lancet (London, England), 2012, 379(9817): 713-720.
[36] [36] LEWIN A S, DRENSER K A, HAUSWIRTH W W, et al. Ribozyme rescue of photoreceptor cells in a transgenic rat model of autosomal dominant retinitis pigmentosa[J]. Nature Medicine, 1998, 4(8): 967-971.
[37] [37] FRIEDLANDER M. Fibrosis and diseases of the eye[J]. Journal of Clinical Investigation, 2007, 117(3): 576-586.
[38] [38] HANISCH U K, KETTENMANN H. Microglia: active sensor and versatile effector cells in the normal and pathologic brain[J]. Nature Neuroscience, 2007, 10(11): 1387-1394.
[39] [39] INMAN D M, HORNER P J. Reactive nonproliferative gliosis predominates in a chronic mouse model of glaucoma[J]. Glia, 2007, 55(9): 942-953.
[40] [40] RAMACHANDRAN R, ZHAO X F D. Ascl1a/dkk/β-catenin signaling pathway is necessary and glycogen synthase kinase-3β inhibition is sufficient for zebrafish retina regeneration[J]. Proceedings of the National Academy of Sciences, 2011, 108(38): 15858-15863.
[41] [41] MEYERS J R, HU L, MOSES A, et al. Β-catenin/Wnt signaling controls progenitor fate in the developing and regenerating zebrafish retina[J]. Neural Development, 2012, 7(1): 30.
[42] [42] OSAKADA F, OOTO S, AKAGI T, et al. Wnt signaling promotes regeneration in the retina of adult mammals[J]. Journal of Neuroscience, 2007, 27(15): 4210-4219.
[43] [43] TODD L, VOLKOV L I, ZELINKA C, et al. Heparin-binding egf-like growth factor (HB-EGF) stimulates the proliferation of Müller glia-derived progenitor cells in avian and murine retinas[J]. Molecular and Cellular Neurosciences, 2015, 69: 54-64.
[44] [44] HILL CAROLINE S, TREISMAN R. Transcriptional regulation by extracellular signals: mechanisms and specificity[J]. Cell, 1995, 80(2): 199-211.
[45] [45] MARSHALL CHRISTOPHER J. Map kinase kinase kinase, map kinase kinase and map kinase[J]. Current Opinion in Genetics & Development, 1994, 4(1): 82-89.
[46] [46] NELSON C M, ACKERMAN K M, O’HAYER P, et al. Tumor necrosis factor-alpha is produced by dying retinal neurons and is required for muller glia proliferation during zebrafish retinal regeneration[J]. The Journal of Neuroscience: the Official Journal of the Society for Neuroscience, 2013, 33(15): 6524-6539.
[47] [47] CAMPBELL L J, HOBGOOD J S, JIA M, et al. Notch3 and DeltaB maintain Müller glia quiescence and act as negative regulators of regeneration in the light-damaged zebrafish retina[J]. Glia, 2021, 69(3): 546-566.
[48] [48] CAMPBELL L J, LEVENDUSKY J L, STEINES S A, et al. Retinal regeneration requires dynamic notch signaling[J]. Neural Regeneration Research, 2022, 17(6): 1199-1209.
[49] [49] LEVY D E, LEE C K. What does stat3 do?[J]. Journal of Clinical Investigation, 2002, 109(9): 1143-1148.
[50] [50] NELSON C M, GORSUCH R A, BAILEY T J, et al. Stat3 defines three populations of Müller glia and is required for initiating maximal Müller glia proliferation in the regenerating zebrafish retina[J]. The Journal of Comparative Neurology, 2012, 520(18): 4294-4311.
[51] [51] ZHAO X F, WAN J, POWELL C, et al. Leptin and IL-6 family cytokines synergize to stimulate Müller glia reprogramming and retina regeneration[J]. Cell Reports, 2014, 9(1): 272-284.
[52] [52] SHARMA P, GUPTA S, CHAUDHARY M, et al. Oct4 mediates Müller glia reprogramming and cell cycle exit during retina regeneration in zebrafish[J]. Life Science Alliance, 2019, 2(5): e201900548.
[53] [53] RAMACHANDRAN R, FAUSETT B, VGOLDMAN D. Ascl1a regulates Müller glia dedifferentiation and retinal regeneration through a lin-28-dependent, let-7 microrna signalling pathway[J]. Nature Cell Biology, 2010, 12(11): 1101-1107.
[56] [56] BROACH J R, GUARASCIO V R, JAYARAM M. Recombination within the yeast plasmid 2mu circle is site-specific[J]. Cell, 1982, 29(1): 227-234.
[57] [57] ABREMSKI K, HOESS R. Bacteriophage p1 site-specific recombination. Purification and properties of the cre recombinase protein[J]. Journal of Biological Chemistry, 1984, 259(3): 1509-1514.
[58] [58] SAUER B, MCDERMOTT J. DNA recombination with a heterospecific cre homolog identified from comparison of the pac-c1 regions of p1-related phages[J]. Nucleic Acids Research, 2004, 32(20): 6086-6095.
[59] [59] LIU K, TANG M, JIN H, et al. Triple-cell lineage tracing by a dual reporter on a single allele[J]. Journal of Biological Chemistry, 2020, 295(3): 690-700.
[60] [60] SAJGO S, GHINIA M G, SHI M, et al. Dre-cre sequential recombination provides new tools for retinal ganglion cell labeling and manipulation in mice[J]. PLoS One, 2014, 9(3): e91435.
[61] [61] YU W, MOOKHERJEE S, CHAITANKAR V, et al. Nrl knockdown by AAV-delivered CRISPR/Cas9 prevents retinal degeneration in mice[J]. Nature Communications, 2017, 8: 14716.
[62] [62] CAI Y, CHENG T, YAO Y, et al. In vivo genome editing rescues photoreceptor degeneration via a cas9/Reca-mediated homology-directed repair pathway[J]. Science Advances, 2019, 5(4): eaav3335.
[63] [63] OOTO S, AKAGI T, KAGEYAMA R, et al. Potential for neural regeneration after neurotoxic injury in the adult mammalian retina[J]. Proceedings of the National Academy of Sciences of the United States of America, 2004, 101(37): 13654-13659.
[64] [64] KARL M O, HAYES S, NELSON B R, et al. Stimulation of neural regeneration in the mouse retina[J]. Proceedings of the National Academy of Sciences of the United States of America, 2008, 105(49): 19508-19513.
[65] [65] JORSTAD N L, WILKEN M S, GRIMES W N, et al. Stimulation of functional neuronal regeneration from Müller glia in adult mice[J]. Nature, 2017, 548(7665): 103-107.
[66] [66] YAO K, QIU S, WANG Y V, et al. Restoration of vision after de novo genesis of rod photoreceptors in mammalian retinas[J]. Nature, 2018, 560(7719): 484-488.
[67] [67] TODD L, FINKBEINER C, WONG C K, et al. Microglia suppress Ascl1-induced retinal regeneration in mice[J]. Cell Reports, 2020, 33: 108507.
[68] [68] TODD L, HOOPER M J, HAUGAN A K, et al. Efficient stimulation of retinal regeneration from Müller glia in adult mice using combinations of proneural bhlh transcription factors[J]. Cell Reports, 2021, 37(3): 109857.
[69] [69] CRAIG S E, CALINESCU A A, HITCHCOCK P F. Identification of the molecular signatures integral to regenerating photoreceptors in the retina of the zebra fish[J]. Journal of Ocular Biology, Diseases, and Informatics, 2008, 1(2/4): 73-84.
[70] [70] XU D, ZHONG L T, CHENG H Y, et al. Overexpressing neurod1 reprograms Müller cells into various types of retinal neurons[J]. Neural Regeneration Research, 2023, 18(5): 1124-1131.
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WEI Yu, MA Qiong, WANG Changke, LIANG Yuling, KANG Hongxiang. Advances in Optic Nerve Regenerative Repair Signaling Pathways and Gene Editing Therapeutics[J]. Acta Laser Biology Sinica, 2023, 32(5): 414
Received: Jun. 29, 2023
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Published Online: Jan. 27, 2024
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