Chinese Journal of Lasers, Volume. 51, Issue 3, 0307204(2024)

Numerical Simulation of Thrombus Propulsion Mechanism Induced by Laser Plasma Detonation Wave

Yang Ge1, Hanyang Li2、*, Hongtao Wang3, Ying Chen1, Xulong Yang2, and Gaoqian Zhou2
Author Affiliations
  • 1College of Mechanical and Electrical Engineering, Harbin Engineering University, Harbin 150001, Heilongjiang , China
  • 2College of Physics and Optoelectronic Engineering, Harbin Engineering University, Harbin 150001, Heilongjiang , China
  • 3Avic Harbin Aircraft Industry Group Co., Ltd., Harbin 150066, Heilongjiang , China
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    Figures & Tables(18)
    Rayleigh line and Hugoniot curve
    One dimensional model of laser plasma detonation wave
    Schematic diagram of laser plasma detonation wave formation under shock wave mechanism
    Diagram of human blood vessels
    Distribution of detonation wave pressure flow field at different time. (a) 5 ns; (b) 10 ns; (c) 20 ns
    Pressure curves at different locations in the direction of detonation wave propagation
    Diagram of fiber laser detonation wave promoting thrombus in blood vessel
    Simplified model of arterial vessel containing thrombus
    Cloud images of thrombus pressure flow field promoted by fiber laser at different time. (a) Artery, 0.01 μs; (b) artery, 0.05 μs; (c) artery, 0.5 μs; (d) vein, 0.01 μs; (e) vein, 0.05 μs; (f) vein, 0.5 μs
    Thrust analysis of arterial and venous thrombi in vessels
    Thrust curves under different laser energies
    Force curves of different propulsion targets
    Experimental schematic diagram. (a) System diagram; (b) physical drawing
    The movement of microsphere at different time with laser energy of 25 μJ. (a) 0 ms; (b) 0.25 ms; (c) 3.25 ms; (d) 4 ms
    Experiments of underwater microsphere clusters driven by conical optical fiber. (a) Microsphere particle cluster; (b) breaking up microsphere cluster; (c) removal effect
    • Table 1. Physical parameters of the blood

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      Table 1. Physical parameters of the blood

      Physical propertyValue
      Density /(kg·m-31050‒1060
      Specific heat /(J·kg-1·K-13770
      Thermal conductivity /(W·m-1·K-10.52
      Temperature /℃38±0.3
      pH7.35‒7.45
      ViscosityNon-Newtonian fluid
      Relative viscosity4‒5
      Blood diastolic pressure /mmHg90‒139
      Blood systolic pressure /mmHg60‒89
    • Table 2. Non-Newtonian fluid parameters of the blood

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      Table 2. Non-Newtonian fluid parameters of the blood

      Non-Newtonian parameterValue
      Consistency index0.644
      Power-law index0.392
      Minimum viscosity limit0.0022
      Maximum viscosity limit0.022
    • Table 3. Physical parameters of the two blood environments

      View table

      Table 3. Physical parameters of the two blood environments

      Blood environment

      Density /

      (kg·m-3

      Specific heat /

      (J·kg-1·K-1

      Thermal conductivity /

      (W·m-1·K-1

      Pressure /

      kPa

      Vascular diameter /mm

      Velocity of flow /

      (cm·s-1

      Viscosity
      Arteriae lower extremis105037700.5218.7530Non-Newtonian fluid
      Venae lower extremis105037700.52101010Non-Newtonian fluid
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    Yang Ge, Hanyang Li, Hongtao Wang, Ying Chen, Xulong Yang, Gaoqian Zhou. Numerical Simulation of Thrombus Propulsion Mechanism Induced by Laser Plasma Detonation Wave[J]. Chinese Journal of Lasers, 2024, 51(3): 0307204

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    Paper Information

    Category: Optical Diagnostics and Therapy

    Received: Aug. 4, 2023

    Accepted: Nov. 9, 2023

    Published Online: Jan. 24, 2024

    The Author Email: Li Hanyang (hanyang_li@hrbeu.edu.cn)

    DOI:10.3788/CJL231086

    CSTR:32183.14.CJL231086

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