Fig. 1. (Color online) Examples of OCT images of an aorta area with calcified depositions and a comparison with histology of the same region. (A) An OCT C-scan image of a 4mm×4mm area with large inclusions. (B) Representative B scans of the positions indicated in (A). P1 and P2 show obvious calcification, which was confirmed by histopathology shown in row (C). P3 does not show significant inclusions. The scale bar in (B) is 1 mm.

Fig. 2. (Color online) OCT and Raman images of the calcified plaque deposition also shown in Figure 1. (A) and (B) OCT C and B scans of the aorta wall, whereby (B) shows the top view. The corresponding Raman images and the associated Raman spectra are shown in (C) and (D), as well as (E) and (F) for a value chain analysis (VCA) and K-means cluster analysis, respectively.