Journal of Innovative Optical Health Sciences, Volume. 18, Issue 2, 2450023(2025)
Mean-reverting diffusion model-enhanced acoustic-resolution photoacoustic microscopy for resolution enhancement: Toward optical resolution
Acoustic-resolution photoacoustic microscopy (AR-PAM) suffers from degraded lateral resolution due to acoustic diffraction. Here, a resolution enhancement strategy for AR-PAM via a mean-reverting diffusion model was proposed to achieve the transition from acoustic resolution to optical resolution. By modeling the degradation process from high-resolution image to low-resolution AR-PAM image with stable Gaussian noise (i.e., mean state), a mean-reverting diffusion model is trained to learn prior information of the data distribution. Then the learned prior is employed to generate a high-resolution image from the AR-PAM image by iteratively sampling the noisy state. The performance of the proposed method was validated utilizing the simulated and in vivo experimental data under varying lateral resolutions and noise levels. The results show that an over 3.6-fold enhancement in lateral resolution was achieved. The image quality can be effectively improved, with a notable enhancement of ∼66% in PSNR and ∼480% in SSIM for in vivo data.
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Yiyang Cao, Shunfeng Lu, Cong Wan, Yiguang Wang, Xuan Liu, Kangjun Guo, Yubin Cao, Zilong Li, Qiegen Liu, Xianlin Song. Mean-reverting diffusion model-enhanced acoustic-resolution photoacoustic microscopy for resolution enhancement: Toward optical resolution[J]. Journal of Innovative Optical Health Sciences, 2025, 18(2): 2450023
Category: Research Articles
Received: Jun. 7, 2024
Accepted: Aug. 6, 2024
Published Online: Apr. 7, 2025
The Author Email: Qiegen Liu (liuqiegen@ncu.edu.cn), Xianlin Song (songxianlin@ncu.edu.cn)