Large-sized Ti∶Al2O3 crystals with the weight of 115 kg were grown successfully by Kyropoulos method. The grown crystals have complete shape without any cracking. Large Ti∶Al2O3 single crystal sample with diameter of 300 mm was prepared. The scintillation luminescence properties of the grown crystals were tested under the X-ray and α particle excitation. The results show that the scintillation luminescence of Ti∶Al2O3 crystals include near infrared band and near ultraviolet band. The near infrared emission comes from the characteristic emission of Ti3+, which has high efficiency and slow decay time. The near ultraviolet emission comes from Ti-localized exciton emission and F+center, which has the fast decay time. The light output is related to the self-absorption caused by Ti-doping. Under the excitation of the α particles, the light yield reaches up to 1 130.5 pe/MeV, and the fast component is 29.6 pe/MeV.