[1] [1] LEFEVRE S, MEIER F M, NEUMANN E, et al. Role of synovial fibroblasts in rheumatoid arthritis ［J］. Current Pharmaceutical Design, 2015, 21(2): 130-141.

[2] [2] WANG G, MU R, XU H. Management of rheumatoid arthritis in People’s Republic of China: focus on tocilizumab and patient considerations ［J］. International Journal of General Medicine, 2015, 8: 187-194.

[3] [3] LI Z, YANG Y. Rheumatology in China: challenges and development ［J］. Rheumatology (Oxford), 2012, 51(10): 1733-1734.

[4] [4] ZHANG Q, LIU J, ZHANG M, et al. Apoptosis induction of fibroblast-like synoviocytes is an important molecular-mechanism for herbal medicine along with its active components in treating rheumatoid arthritis ［J］. Biomolecules, 2019, 9(12): 795.

[5] [5] BUSTAMANTE M F, GARCIA-CARBONELL R, WHISENANT K D, et al. Fibroblast-like synoviocyte metabolism in the pathogenesis of rheumatoid arthritis ［J］. Arthritis Research & Therapy, 2017, 19(1): 110.

[6] [6] ZHANG K, GAO S, GUO J, et al. Hypericin-photodynamic therapy inhibits proliferation and induces apoptosis in human rheumatoid arthritis fibroblast-like synoviocytes cell line MH7A ［J］. Iranian Journal of Basic Medical Sciences, 2018, 21(2): 130-137.

[7] [7] KAYAMA Y, SHIBATA M, TAKIZAWA T, et al. Functional interactions between transient receptor potential M8 and transient receptor potential V1 in the trigeminal system: relevance to migraine pathophysiology ［J］. Cephalalgia, 2018, 38(5): 833-845.

[8] [8] COSENSD J, MANNING A. Abnormal electroretinogram from a Drosophila mutant ［J］. Nature, 1969, 224: 258-287.

[9] [9] VENKATACHALAM K, MONTELL C. TRP channels ［J］. Annual Review of Biochemistry, 2007, 76: 387-417.

[10] [10] CABRAL L D, GIUSTI-PAIVA A. The transient receptor potential vanilloid 1 antagonist capsazepine improves the impaired lung mechanics during endotoxemia ［J］. Basic & Clinical Pharmacology & Toxicology, 2016, 119(5): 421-427.

[11] [11] ZHAI K, LISKOVA A, KUBATKA P, et al. Calcium entry through trpv1: a potential target for the regulation of proliferation and apoptosis in cancerous and healthy cells ［J］. International Journal of Molecular Sciences, 2020, 21(11): 4177.

[12] [12] BAGOOD M D, ISSEROFF R R. TRPV1: role in skin and skin diseases and potential target for improving wound healing ［J］. International Journal of Molecular Sciences, 2021, 22(11): 6135.

[13] [13] WANG Y, WANG D H. TRPV1 ablation aggravates inflammatory responses and organ damage during endotoxic shock ［J］. Clinical and Vaccine Immunology, 2013, 20(7): 1008-1015.

[14] [14] HOU N, HE X, YANG Y, et al. TRPV1 induced apoptosis of colorectal cancer cells by activating calcineurin-NFAT2-p53 signaling pathway ［J］. Biomed Research International, 2019, 2019: 6712536.

[15] [15] DE JONG P R, TAKAHASHI N, HARRIS A R, et al. Ion channel TRPV1-dependent activation of PTP1B suppresses EGFR-associated intestinal tumorigenesis ［J］. Journal of Clinical Investigation, 2014, 124(9): 3793-3806.

[16] [16] BLAGOSKLONNY M V. P53: an ubiquitous target of anticancer drugs ［J］. International Journal of Cancer, 2002, 98(2): 161-166.

[17] [17] WU T T, PETERS A A, TAN P T, et al. Consequences of activating the calcium-permeable ion channel TRPV1 in breast cancer cells with regulated TRPV1 expression ［J］. Cell Calcium, 2014, 56(2): 59-67.

[18] [18] ANDERS J J, LANZAFAME R J, ARANY P R. Low-level light/laser therapy versus photobiomodulation therapy ［J］. Photomedicine Laser Surgery, 2015, 33(4): 183-184.

[19] [19] BAXTER G D, LIU L, PETRICH S, et al. Low level laser therapy (photobiomodulation therapy) for breast cancer-related lymphedema: a systematic review ［J］. BMC Cancer, 2017, 17(1): 833.

[20] [20] SANTINONI C D, OLIVEIRA H F, BATISTA V E, et al. Influence of low-level laser therapy on the healing of human bone maxillofacial defects: a systematic review ［J］. Journal of Photochemistry and Photobiology B-Biology, 2017, 169: 83-89.

[21] [21] AVCI P, GUPTA A, SADASIVAM M, et al. Low-level laser (light) therapy (LLLT) in skin: stimulating, healing, restoring ［J］. Seminars in Cutaneous Medicine and Surgery, 2013, 32(1): 41-52.

[22] [22] JANG D H, SONG D H, CHANG E J, et al. The effects of photobiomodulation therapy on mouse pre-osteoblast cell line MC3T3-E1 proliferation and apoptosis via miR-503/Wnt3a pathway ［J］. Lasers in Medical Science, 2019, 34(3): 607-614.

[23] [23] SANTINONI C S, NEVES A P C, ALMEIDA B F M, et al. Bone marrow coagulated and low-level laser therapy accelerate bone healing by enhancing angiogenesis, cell proliferation, osteoblast differentiation, and mineralization ［J］. Journal of Biomedical Materials Research Part A, 2021, 109(6): 849-858.

[24] [24] CHEN A C, ARANY P R, HUANG Y Y, et al. Low-level laser therapy activates NF-kB via generation of reactive oxygen species in mouse embryonic fibroblasts ［J］. PLoS One, 2011, 6(7): e22453.

[25] [25] ZHANG L, ZHANG Y, XING D. LPLI inhibits apoptosis upstream of Bax translocation via a GSK-3beta-inactivation mechanism ［J］. Journal of Cellular Physiology, 2010, 224(1): 218-228.

[26] [26] SPERANDIO F F, GIUDICE F S, CORREA L, et al. Low-level laser therapy can produce increased aggressiveness of dysplastic and oral cancer cell lines by modulation of Akt/mTOR signaling pathway ［J］. Journal of Biophotonics, 2013, 6(10): 839-847.

[27] [27] POPE R M. Apoptosis as a therapeutic tool in rheumatoid arthritis ［J］. Nature Reviews Immunology, 2002, 2(7): 527-535.

[28] [28] YAMAURA M, YAO M, YAROSLAVSKY I, et al. Low level light effects on inflammatory cytokine production by rheumatoid arthritis synoviocytes ［J］. Lasers in Surgery and Medicine, 2009, 41(4): 282-290.

[29] [29] MENG C, XIA Q, WU H, et al. Photobiomodulation with 630?nm LED radiation inhibits the proliferation of human synoviocyte MH7A cells possibly via TRPV4/PI3K/AKT/mTOR signaling pathway ［J］. Lasers in Medical Science, 2020, 35(9): 1927-1936.

[30] [30] CATERINA M J, SCHUMACHER M A, TOMINAGA M, et al. The capsaicin receptor: a heat-activated ion channel in the pain pathway ［J］. Nature, 1997, 389(6653): 816-824.

[31] [31] STOCK K, KUMAR J, SYNOWITZ M, et al. Neural precursor cells induce cell death of high-grade astrocytomas through stimulation of TRPV1 ［J］. Nature Medicine, 2012, 18(8): 1232-1238.

[32] [32] NAZIROGLU M, CIG B, BLUM W, et al. Targeting breast cancer cells by MRS1477, a positive allosteric modulator of TRPV1 channels ［J］. PLoS One, 2017, 12(6): e0179950.

[33] [33] CHUNG M K, GULER A D, CATERINA M J. TRPV1 shows dynamic ionic selectivity during agonist stimulation ［J］. Nature Neuroscience, 2008, 11(5): 555-564.

[34] [34] LIU T, WANG G, TAO H, et al. Capsaicin mediates caspases activation and induces apoptosis through P38 and JNK MAPK pathways in human renal carcinoma ［J］. BMC Cancer, 2016, 16(1): 790.

[35] [35] AMANTINI C, BALLARINI P, CAPRODOSSI S, et al. Triggering of transient receptor potential vanilloid type 1 (TRPV1) by capsaicin induces Fas/CD95-mediated apoptosis of urothelial cancer cells in an ATM-dependent manner ［J］. Carcinogenesis, 2009, 30(8): 1320-1329.

[36] [36] WANG Y, HUANG Y Y, WANG Y, et al. Red (660 nm) or near-infrared (810 nm) photobiomodulation stimulates, while blue (415?nm), green (540 nm) light inhibits proliferation in human adipose-derived stem cells ［J］. Scientific Reports, 2017, 7(1): 7781.

[37] [37] LOWIN T, PONGRATZ G, STRAUB R H. The synthetic cannabinoid WIN55, 212-2 mesylate decreases the production of inflammatory mediators in rheumatoid arthritis synovial fibroblasts by activating CB2, TRPV1, TRPA1 and yet unidentified receptor targets ［J］. Journal of Inflammation-London, 2016, 13(1): 1-10.

[38] [38] HU F, SUN W W, ZHAO X T, et al. TRPV1 mediates cell death in rat synovial fibroblasts through calcium entry-dependent ROS production and mitochondrial depolarization ［J］. Biochemical and Biophysical Research Communications, 2008, 369(4): 989-993.