Chinese Journal of Lasers, Volume. 45, Issue 2, 207008(2018)
Tumor-Microenvironment Activable Smart Nanocarrier System for Photodynamic Therapy of Cancers
Fig. 1. (a) Fabrication of photosensitive nanoparticles by amphiphilic dipeptide- or amino-acid- tuned self-assembly; (b) whole body fluorescence images of MCF7-tumor-bearing nude mice intravenously injected through a tail vein with FCNPs and free Ce6 (equivalent to 4.0 mg Ce6 per kilogram FCNs) at different times, black circles indicate tumor sites; (c) measured tumor size for 20 days growth (the number of mice in each group n=4)
Fig. 2. Schematic of ALA pseudopolyrotaxane prodrug micelles for photodynamic therapy
Fig. 3. (a) Synthesis of the disulfide rebridging and bioconjugation reagent 6 (azide double sulfone); (b) functionalization of SST to receive Ru-SST conjugate 8 (Ru-SST8)
Fig. 4. A concept of enzyme activatable fluorescence imaging and photodynamic therapy using a photosensitizer-conjugated gold nanorod (MMP2P-GNR)
Fig. 5. Simplified representation of a stepwise assembly process of final APMECR@MB NCs and the synergistic PDT/PTT mechanism of their action
Fig. 6. Schematic of TMB. (a) FRET mode of TMB in the closed and opened forms; (b) hairpin DNA sequence and the separation distance of each FRET pair
Fig. 7. A schematic of activatable nano-photo medicine for macrophage-targeted fluorescence imaging and subsequent photodynamic therapy
Fig. 8. Schematic illustration of the preparation of Ce6-CPT-UCNPs and concept of the light-regulated ROS-activated Ce6-CPT-UCNPs
Fig. 9. Schematic of the preparation and functional principle of AQ4N-Cu(II)-Apt Ce6-GNPs
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Lan Shanyou, Zhang Da, Liu Xiaolong, Zeng Yongyi. Tumor-Microenvironment Activable Smart Nanocarrier System for Photodynamic Therapy of Cancers[J]. Chinese Journal of Lasers, 2018, 45(2): 207008
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Received: Sep. 14, 2017
Accepted: --
Published Online: Feb. 28, 2018
The Author Email: Yongyi Zeng (lamp1973@medmail.com.cn)