International Journal of Orthopaedics, Volume. 46, Issue 4, 235(2025)

Research progress of autologous collagen-induced chondrogenesis in articular cartilage injury

YANG Yuze, YANG Jiaju, ZHOU Can, and ZHANG Min*
Author Affiliations
  • [in Chinese]
  • show less
    References(29)

    [1] [1] Buckwalter JA. Articular cartilage: injuries and potential for healing[J]. J Orthop Sports Phys Ther, 1998, 28(4): 192-202.

    [2] [2] Kim SJ, Shetty AA, Kurian NM, et al. Articular cartilage repair using autologous collagen-induced chondrogenesis (ACIC): a pragmatic and cost-effective enhancement of a traditional technique[J]. Knee Surg Sports Traumatol Arthrosc, 2020, 28(8): 2598-2603.

    [3] [3] Chun YS, Kim SA, KIM YH, et al. Autologous collagen-induced chondrogenesis: from bench to clinical development[J]. Medicina (Kaunas), 2023, 59(3): 530.

    [4] [4] van Tuijn IM, Emanuel KS, van Hugten PPW, et al. Prognostic factors for the clinical outcome after microfracture treatment of chondral and osteochondral defects in the knee joint: a systematic review[J]. Cartilage, 2023, 14(1): 5-16.

    [5] [5] Enea D, Cecconi S, Busilacchi A, et al. Matrix-induced autologous chondrocyte implantation (MACI) in the knee[J]. Knee Surg Sports Traumatol Arthrosc, 2012, 20(5): 862-869.

    [6] [6] Brittberg M, Lindahl A, Nilsson A, et al. Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation[J]. N Engl J Med, 1994, 331(14): 889-895.

    [7] [7] Na YY, Shi YT, Liu WL, et al. Is implantation of autologous chondrocytes superior to microfracture for articular-cartilage defects of the knee? A systematic review of 5-year follow-up data[J]. Int J Surg, 2019, 68: 56-62.

    [8] [8] McCarthy HS, Roberts S. A histological comparison of the repair tissue formed when using either Chondrogide(®) or periosteum during autologous chondrocyte implantation[J]. Osteoarthritis Cartilage, 2013, 21(12): 2048-2057.

    [9] [9] Demange M, Gomoll AH. The use of osteochondral allografts in the management of cartilage defects[J]. Curr Rev Musculoskelet Med, 2012, 5(3): 229-235.

    [10] [10] Solanki K, Shanmugasundaram S, Shetty N, et al. Articular cartilage repair & joint preservation: a review of the current status of biological approach[J]. J Clin Orthop Trauma, 2021, 22: 101602.

    [11] [11] Armiento AR, Alini M, Stoddart MJ. Articular fibrocartilage: why does hyaline cartilage fail to repair?[J]. Adv Drug Deliv Rev, 2019, 146: 289-305.

    [12] [12] Shi DQ, Xu XQ, Ye YQ, et al. Photo-cross-linked scaffold with kartogenin-encapsulated nanoparticles for cartilage regeneration[J]. ACS Nano, 2016, 10(1): 1292-1299.

    [14] [14] Tuan RS, Chen AF, Klatt BA. Cartilage regeneration[J]. J Am Acad Orthop Surg, 2013, 21(5): 303-311.

    [15] [15] Lai CT, Cheng X, Yuan T, et al. A novel mechanism behind irreversible development of cartilage degradation driven articular cartilage defects revealed by rat model: the chain reaction initiated by extracellular vesicles delivered LOC102546541[J]. Int Immunopharmacol, 2024, 137: 112467.

    [16] [16] Shetty AA, Kim SJ, Bilagi P, et al. Autologous collagen-induced chondrogenesis: single-stage arthroscopic cartilage repair technique[J]. Orthopedics, 2013, 36(5): e648-e652.

    [17] [17] Martin R, Jakob RP. Review of K.H. Pridie (1959) on "A method of resurfacing osteoarthritic knee joints"[J]. J Isakos, 2022, 7(1): 39-46.

    [18] [18] Steadman JR, Rodkey WG, Rodrigo JJ. Microfracture: surgical technique and rehabilitation to treat chondral defects[J]. Clin Orthop Relat Res, 2001, Suppl 391: S362-S369.

    [19] [19] Steadman JR, Rodkey WG, Briggs KK. Microfracture to treat full-thickness chondral defects: surgical technique, rehabilitation, and outcomes[J]. J Knee Surg, 2002, 15(3): 170-176.

    [21] [21] Higuchi A, Ling QD, Hsu ST, et al. Biomimetic cell culture proteins as extracellular matrices for stem cell differentiation[J]. Chem Rev, 2012, 112(8): 4507-4540.

    [22] [22] Zhang JJ, Wu YN, Thote T, et al. The influence of scaffold microstructure on chondrogenic differentiation of mesenchymal stem cells[J]. Biomed Mater, 2014, 9(3): 035011.

    [23] [23] Zhang JJ, Yang Z, Li C, et al. Cells behave distinctly within sponges and hydrogels due to differences of internal structure[J]. Tissue Eng Part A, 2013, 19(19-20): 2166-2175.

    [24] [24] Wise JK, Yarin AL, Megaridis CM, et al. Chondrogenic differentiation of human mesenchymal stem cells on oriented nanofibrous scaffolds: engineering the superficial zone of articular cartilage[J]. Tissue Eng Part A, 2009, 15(4): 913-921.

    [25] [25] Gillogly SD, Wheeler KS. Autologous chondrocyte implantation with collagen membrane[J]. Sports Med Arthrosc Rev, 2015, 23(3): 118-124.

    [26] [26] Gooding CR, Bartlett W, Bentley G, et al. A prospective, randomised study comparing two techniques of autologous chondrocyte implantation for osteochondral defects in the knee: periosteum covered versus type Ⅰ/Ⅲ collagen covered[J]. Knee, 2006, 13(3): 203-210.

    [27] [27] Nehrer S, Breinan HA, Ramappa A, et al. Matrix collagen type and pore size influence behaviour of seeded canine chondrocytes[J]. Biomaterials, 1997, 18(11): 769-776.

    [28] [28] Irawan V, Sung TC, Higuchi A, et al. Collagen scaffolds in cartilage tissue engineering and relevant approaches for future development[J]. Tissue Eng Regen Med, 2018, 15(6): 673-697.

    [29] [29] Angele P, Zellner J, Schrter S, et al. Biological reconstruction of localized full-thickness cartilage defects of the knee: a systematic review of level 1 studies with a minimum follow-up of 5 years[J]. Cartilage, 2022, 13(4): 5-18.

    [30] [30] Stelzeneder D, Shetty AA, Kim SJ, et al. Repair tissue quality after arthroscopic autologous collagen-induced chondrogenesis (ACIC) assessed via T2* mapping[J]. Skeletal Radiol, 2013, 42(12): 1657-1664.

    [31] [31] Shetty AA, Kim SJ, Shetty V, et al. Autologous collagen induced chondrogenesis (ACIC: Shetty-Kim technique): a matrix based acellular single stage arthroscopic cartilage repair technique[J]. J Clin Orthop Trauma, 2016, 7(3): 164-169.

    Tools

    Get Citation

    Copy Citation Text

    YANG Yuze, YANG Jiaju, ZHOU Can, ZHANG Min. Research progress of autologous collagen-induced chondrogenesis in articular cartilage injury[J]. International Journal of Orthopaedics, 2025, 46(4): 235

    Download Citation

    EndNote(RIS)BibTexPlain Text
    Save article for my favorites
    Paper Information

    Category:

    Received: Feb. 6, 2025

    Accepted: Aug. 25, 2025

    Published Online: Aug. 25, 2025

    The Author Email: ZHANG Min (zhangminty126@126.com)

    DOI:10.3969/j.issn.1673-7083.2025.04.007

    Topics