Thermal Analysis and Design of Multichannel Flow Cytometry Laser Platform

Tianji Lei; Wang Chen; Zhencheng Chen; Xuehui Tang; Zihan Zhang; Chu Tan; Fuyin Zhu; Aiwen Liao; Changlin Xiao; Shimin Yin; Cheng Fang

doi:10.3788/LOP240575

Laser & Optoelectronics Progress, Volume. 61, Issue 21, 2117001(2024)

Thermal Analysis and Design of Multichannel Flow Cytometry Laser Platform

Tianji Lei¹, Wang Chen³, Zhencheng Chen¹, Xuehui Tang³, Zihan Zhang², Chu Tan³, Fuyin Zhu³, Aiwen Liao³, Changlin Xiao³, Shimin Yin^1,4、**, and Cheng Fang^1、*

Author Affiliations

¹School of Life and Environmental Sciences, Guilin University of Electronic Technology, Guilin 541004, Guangxi , China

²School of Electronic Engineering and Automation, Guilin University of Electronic Technology, Guilin 541004, Guangxi , China

³URIT Medical Electronic Co., Ltd., Guilin 541004, Guangxi , China

⁴Guangxi Key Laboratory of Automatic Detecting Technology and Instruments, Guilin University of Electronic Technology, Guilin 541004, Guangxi , China

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Figures & Tables(13)

Fig. 1. Simplified model of a multichannel laser for finite element simulation

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Fig. 2. Temperature variations of laser diode and laser platform under different environmental temperatures

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Fig. 3. Finite element simulation and thermal imaging validation. (a) finite element simulation 10 ℃; (b) finite element simulation 25 ℃; (c) finite element simulation 30 ℃; (d) thermal imaging validation 10 ℃; (e) thermal imaging validation 25 ℃; (f) thermal imaging validation 30 ℃

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Fig. 4. New model with the addition of a temperature control system

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Fig. 5. Finite element simulation results of different heating module sizes. (a) Size 1, L=50 mm, W=50 mm; (b) size 2, L=70 mm, W=70 mm; (c) size 3, L=90 mm, W=90 mm; (d) size 4, L=168 mm, W=145 mm, L₁=60 mm, W₁=86 mm

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Fig. 6. Temperature change of laser diode and laser platform after adding temperature control system

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Fig. 7. Visualization of light spot spacing measurement. (a) 10 ℃ without temperature control; (b) 25 ℃ without temperature control; (c) 30 ℃ without temperature control; (d) 10 ℃ with temperature control; (e) 25 ℃ with temperature control; (f) 30 ℃ with temperature control

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Fig. 8. CV test results at environmental temperatures of 10 ℃ and 30 ℃. (a) 10 ℃ without temperature controll; (b) 10 ℃ with temperature controll; (c) 30 ℃ without temperature controll; (d) 30 ℃ with temperature controll

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Table 1. Performance parameter of material

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Table 1. Performance parameter of material

Component	Material	Thermal conductivity $k$ /［W·（m·K）^-1］	Density ρ /（kg·m^-3）	Specific heat $C_{p}$ /［J·（kg·K）^-1］
HS	H59 brass	123	8390	375
LP	7075 aluminum alloy	155	2810	960
LB	6061 aluminum alloy	170	2700	896
LBP	6061 aluminum alloy	170	2700	896
LBSMB	6061 aluminum alloy	170	2700	896
OF	6061 aluminum alloy	170	2700	896
LD	Copper alloy	350	8940	385
shim	Bakelite	0.20	1720	1500
OE	Quartz glass	1.38	2203	703

Table 2. Finite element simulation results and thermal imaging measurement of laser platform under different environmental temperatures
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Table 2. Finite element simulation results and thermal imaging measurement of laser platform under different environmental temperatures
Environmental temperature /℃ Finite element simulation results /℃ Thermal imaging measurements /℃
10 13.9 13.8
25 28.1 27.9
30 35.0 34.9

Table 3. Finite element simulation results of new model with different sizes of heating modules
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Table 3. Finite element simulation results of new model with different sizes of heating modules
Heating module size Laser platform temperature /℃ Laser diode temperature /℃
Size 1 24.4 25.0
Size 2 24.5 25.0
Size 3 24.5 25.0
Size 4 24.6 25.0

Table 4. Relative offset of light spot spacing

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Table 4. Relative offset of light spot spacing

Condition	$δ_{x 1}$ /%	$δ_{x 2}$ /%
10 ℃ without temperature control	-0.86	-1.33
10 ℃ with temperature control	-0.46	-0.46
25 ℃ with temperature control	0.00	0.00
30 ℃ without temperature control	0.86	1.33
30 ℃ with temperature control	0.40	0.86

Table 5. CV test results at different environmental temperatures

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Table 5. CV test results at different environmental temperatures

Condition	FSC /%	FITC /%	PE /%
10 ℃ without temperature controll	1.47	2.37	1.93
10 ℃ with temperature controll	0.99	2.01	1.77
25 ℃ without temperature controll	0.92	1.91	1.61
25 ℃ with temperature controll	0.95	1.91	1.66
30 ℃ without temperature controll	1.66	2.30	2.02
30 ℃ with temperature controll	1.08	2.09	1.91

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Tianji Lei, Wang Chen, Zhencheng Chen, Xuehui Tang, Zihan Zhang, Chu Tan, Fuyin Zhu, Aiwen Liao, Changlin Xiao, Shimin Yin, Cheng Fang. Thermal Analysis and Design of Multichannel Flow Cytometry Laser Platform[J]. Laser & Optoelectronics Progress, 2024, 61(21): 2117001

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Paper Information

Category: Medical Optics and Biotechnology

Received: Jan. 19, 2024

Accepted: Feb. 18, 2024

Published Online: Nov. 13, 2024

The Author Email: Shimin Yin (hawk_ysm@163.com), Cheng Fang (chengfang@guet.edu.cn)

DOI:10.3788/LOP240575

CSTR:32186.14.LOP240575

Topics

laser devices and laser physics

Lasers and Laser Optics

Laser physics

laser manufacturing

Instrumentation, Measurement and Metrology

Table 1. Performance parameter of material

Table 1. Performance parameter of material

Table 2. Finite element simulation results and thermal imaging measurement of laser platform under different environmental temperatures

Table 2. Finite element simulation results and thermal imaging measurement of laser platform under different environmental temperatures

Table 3. Finite element simulation results of new model with different sizes of heating modules

Table 3. Finite element simulation results of new model with different sizes of heating modules

Table 4. Relative offset of light spot spacing

Table 4. Relative offset of light spot spacing

Table 5. CV test results at different environmental temperatures

Table 5. CV test results at different environmental temperatures