Acta Laser Biology Sinica, Volume. 33, Issue 4, 357(2024)

Metformin Inhibits Proliferation and Migration of Liver Cancer Cells Through TGF-β1/Smads Pathway

CHEN Shengsong1,*... LI Huanhuan1 and WU Huirong2 |Show fewer author(s)
Author Affiliations
  • 1Department of Oncology, Chengdu BOE Hospital, Chengdu 610200, China
  • 2Department of Oncology, Wuhou District Third People’s Hospital, Chengdu 610200, China
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    References(12)

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    [6] [6] MA R, YI B, RIKER A I, et al. Metformin and cancer immunity[J]. Acta Pharmacologica Sinica, 2020, 41(11): 1403-1409.

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    [9] [9] KANG B G, SHENDE M, INCI G, et al. Combination of metformin/efavirenz/fluoxetine exhibits profound anticancer activity via a cancer cell-specific ROS amplification[J]. Cancer Biology & Therapy, 2023, 24(1): 20-32.

    [10] [10] YUAN H, HAN Y, WANG X, et al. SETD2 restricts prostate cancer metastasis by integrating EZH2 and AMPK signaling pathways[J]. Cancer Cell, 2020, 38(3): 350-365.

    [12] [12] MA S, ZHENG Y, XIAO Y, et al. Meta-analysis of studies using metformin as a reducer for liver cancer risk in diabetic patients[J]. University of Maryland Medicine (Baltimore), 2017, 96(19): e6888.

    [13] [13] KIM T S, LEE M, PARK M, et al. Metformin and dichloroacetate suppress proliferation of liver cancer cells by inhibiting mTOR complex 1[J]. International Journal of Molecular Sciences, 2021, 22(18): 10027.

    [16] [16] HACHIM M Y, HACHIM I Y, DAI M, et al. Differential expression of TGF isoforms in breast cancer highlights different roles during breast cancer progression[J]. Tumor Biology, 2018, 40(1): 1010428317748254.

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    CHEN Shengsong, LI Huanhuan, WU Huirong. Metformin Inhibits Proliferation and Migration of Liver Cancer Cells Through TGF-β1/Smads Pathway[J]. Acta Laser Biology Sinica, 2024, 33(4): 357

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    Paper Information

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    Received: Aug. 23, 2023

    Accepted: Dec. 20, 2024

    Published Online: Dec. 20, 2024

    The Author Email: CHEN Shengsong (qlscss@163.com)

    DOI:10.3969/j.issn.1007-7146.2024.04.008

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