Laboratory Animal and Comparative Medicine, Volume. 45, Issue 3, 259(2025)
Cartilage Protection and Anti-Inflammatory Effects of Fraxetin on Monosodium Iodoacetate-Induced Rat Model of Osteoarthritis
[1] [1] GIORGINO R, ALBANO D, FUSCO S, et al. Knee osteoarthritis: epidemiology, pathogenesis, and mesenchymal stem cells: what else is new? an update[J]. Int J Mol Sci, 2023, 24(7): 6405. DOI: 10.3390/ijms24076405.
[2] [2] ZHAO J L, YANG W Y, LIANG G H, et al. The efficacy and safety of Jinwu Gutong capsule in the treatment of knee osteoarthritis: a meta-analysis of randomized controlled trials[J]. J Ethnopharmacol, 2022, 293: 115247. DOI: 10.1016/j.jep.2022.115247.
[7] [7] WANG Q, ZHUANG D, FENG W C, et al. Fraxetin inhibits interleukin-1-induced apoptosis, inflammation, and matrix degradation in chondrocytes and protects rat cartilagein vivo[J]. Saudi Pharm J, 2020, 28(12): 1499-1506. DOI: 10.1016/j.jsps.2020.09.016.
[8] [8] WU Q, YAO X B, SHAN N, et al. Platelet-rich plasma ameliorates cartilage degradation in rat models of osteoarthritisviathe OPG/RANKL/RANK system[J]. Folia Histochem Cytobiol, 2024, 62(3): 154-164. DOI: 10.5603/fhc.100179.
[10] [10] XU Z X, KE T, ZHANG Y F, et al. Danshensu inhibits the IL-1-induced inflammatory response in chondrocytes and osteoarthritis possiblyviasuppressing NF-B signaling pathway[J]. Mol Med, 2021, 27(1): 80. DOI: 10.1186/s10020-021-00329-9.
[11] [11] KOVCS B, VAJDA E, NAGY E E. Regulatory effects and interactions of the Wnt and OPG-RANKL-RANK signaling at the bone-cartilage interface in osteoarthritis[J]. Int J Mol Sci, 2019, 20(18): 4653. DOI: 10.3390/ijms20184653.
[12] [12] ROSAS S, KWOK A, MOORE J, et al. Osteoarthritis as a systemic disease promoted prostate cancerin vivoandin vitro[J]. Int J Mol Sci, 2024, 25(11): 6014. DOI: 10.3390/ijms25116014.
[13] [13] YAO Q, WU X H, TAO C, et al. Osteoarthritis: pathogenic signaling pathways and therapeutic targets[J]. Signal Transduct Target Ther, 2023, 8(1): 56. DOI: 10.1038/s41392-023-01330-w.
[14] [14] ULIVI V, GIANNONI P, GENTILI C, et al. p38/NF-kB-dependent expression of COX-2 during differentiation and inflammatory response of chondrocytes[J]. J Cell Biochem, 2008, 104(4): 1393-1406. DOI: 10.1002/jcb.21717.
[15] [15] LU J S, ZHANG H B, PAN J Y, et al. Fargesin ameliorates osteoarthritisviamacrophage reprogramming by downregulating MAPK and NF-B pathways[J]. Arthritis Res Ther, 2021, 23(1): 142. DOI: 10.1186/s13075-021-02512-z.
[16] [16] DING D, YAN J B, FENG G N, et al. Dihydroartemisinin attenuates osteoclast formation and bone resorptionviainhibiting the NF-B, MAPK and NFATc1 signaling pathways and alleviates osteoarthritis[J]. Int J Mol Med, 2022, 49(1): 4. DOI: 10.3892/ijmm.2021.5059.
[17] [17] LIAO J C, WEI Z X, ZHAO C, et al. Inhibition of osteoclastogenesis for periprosthetic osteolysis therapy through the suppression of p38 signaling by fraxetin[J]. Int J Mol Med, 2018, 42(3): 1257-1264. DOI: 10.3892/ijmm.2018.3698.
[21] [21] WU B, WANG R, LI S N, et al. Antifibrotic effects of Fraxetin on carbon tetrachloride-induced liver fibrosis by targeting NF-B/IB, MAPKs and Bcl-2/Bax pathways[J]. Pharmacol Rep, 2019, 71(3): 409-416. DOI: 10.1016/j.pharep.2019.01.008.
[22] [22] WITAICENIS A, SEITO L N, DA SILVEIRA CHAGAS A, et al. Antioxidant and intestinal anti-inflammatory effects of plant-derived coumarin derivatives[J]. Phytomedicine, 2014, 21(3): 240-246. DOI: 10.1016/j.phymed.2013.09.001.
[23] [23] DE SOUSA VALENTE J. The pharmacology of pain associated with the monoiodoacetate model of osteoarthritis[J]. Front Pharmacol, 2019, 10: 974. DOI: 10.3389/fphar.2019.00974.
[24] [24] MA T W, ZHANG Z H, SONG X P, et al. Combined detection of COMP and CS846 biomarkers in experimental rat osteoarthritis: a potential approach for assessment and diagnosis of osteoarthritis[J]. J Orthop Surg Res, 2018, 13(1): 230. DOI: 10.1186/s13018-018-0938-3.
[25] [25] CHEN J Y, ZHANG L, ZHANG H, et al. Triggering of p38 MAPK and JNK signaling is important for oleanolic acid-induced apoptosis via the mitochondrial death pathway in hypertrophic scar fibroblasts[J]. Phytother Res, 2014, 28(10): 1468-1478. DOI: 10.1002/ptr.5150.
[26] [26] LI X H, ZHANG Z L, LIANG W N, et al. Tougu Xiaotong capsules may inhibit p38 MAPK pathway-mediated inflammation: In vivo and in vitro verification[J]. J Ethnopharmacol, 2020, 249: 112390. DOI: 10.1016/j.jep.2019.112390.
Get Citation
Copy Citation Text
LIU Zhiwei, YANG Ran, LIAN Hao, ZHANG Yu, JIN Lilun. Cartilage Protection and Anti-Inflammatory Effects of Fraxetin on Monosodium Iodoacetate-Induced Rat Model of Osteoarthritis[J]. Laboratory Animal and Comparative Medicine, 2025, 45(3): 259
Category:
Received: Nov. 8, 2024
Accepted: Aug. 26, 2025
Published Online: Aug. 26, 2025
The Author Email: JIN Lilun (jinlilun@xinhuamed.com.cn)