[1] [1] DI SOTTO A, MAFFEI F, HRELIA P,et al. Genotoxicity assessment of some cosmetic and food additives [J]. Regulatory Toxicology and Pharmacology, 2014, 68(1): 16-22.

[2] [2] FAOUR B Y. Lilial’s controversy: what is it and why has it been banned? [EB/OL]. [2024-05-29]. https://www.emotion-master-studentproject.eu/post/lilial-s-controversy-what-is-it-and-why-has-it-been-banned.

[3] [3] BAJORIA V. Butylphenyl methylpropional in cosmetics &personal care products [EB/OL]. [2024-05-29]. https://periodical.knowde.com/butylphenyl-methylpropional-in-cosmetics-personal-care-products/.

[4] [4] MSL. EU bans the use of a common fragrance ingredient: butylphenyl methylpropional (BMHCA, lilial) [EB/OL]. [2024-05-29]. https://msl.io/news/eu-bans-the-use-of-a-common-fragrance-ingredient-butylphenyl-methylpropional-bmhca-lilial/.

[5] [5] EU. Commission Regulation (EU) 2021/1902 [EB/OL]. [2024-05-29]. https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX%3A32021R1902.

[6] [6] NITE. NITE-CHRIP [EB/OL]. [2024-05-29]. https://www.nite.go.jp/chem/chrip/chrip_search/cmpInfDsp?cid=C005-483-16A&bcPtn=0&shMd=0&txNumSh=ODAtNTQtNg==&ltNumTp=1&ltNumMh=0&txNmSh=&ltNmTp=&ltNmMh=1&txNmSh1=&ltNmTp1=&txNmSh2=&ltNmTp2=&txNmSh3=&ltNmTp3=&txMlSh=&ltMlMh=0&ltScDp=0&ltPgCtSt=100&rbDp=0&txScSML=&txScSML2=&ltScTp=1&txUpScFl=null&hdUpScPh=&hdUpHash=&rbScMh=1&txScNyMh=&txMlWtSt=&txMlWtEd=&err=.

[8] [8] EWG. Lilial and fertility: EU bans toxic fragrance ingredient from personal care products [EB/OL]. [2024-05-29]. https://www.ewg.org/news-insights/news-release/2022/03/lilial-and-fertility-eu-bans-toxic-fragrance-ingredient-personal.

[9] [9] CRITICALCATALYST. Butylphenyl methylpropional to be prohibited in cosmetics placed in the EU market [EB/OL].[2024-05-29]. https://criticalcatalyst.com/butylphenyl-methylpropional-to-be-prohibited-in-cosmetics-placed-in-the-eu-market/.

[10] [10] OBELIS. SCCS final opinion on the safety of Butylphenyl methylpropional (p-BMHCA) [EB/OL]. [2024-05-29]. https://www.obelis.net/news/sccs-final-opinion-on-the-safety-of-butyl-phenyl-methylpropional-p-bmhca/.

[11] [11] API A M, BELSITO D, BISERTA S,et al. RIFM fragrance ingredient safety assessment,p-t-butyl--methylhydrocinnamic aldehyde, CAS registry number 80-54-6 [J]. Food and Chemical Toxicology, 2020, 141(Suppl 1): 111430.

[12] [12] EU. Commission Delegated Regulation (EU) 2020/1182 [EB/OL]. [2024-05-29]. https://eur-lex.europa.eu/eli/reg_del/2020/1182/oj.

[13] [13] SGS. EU amends cosmetics regulation in response to cmr substances [EB/OL]. [2024-05-29]. https://www.sgs.com/en/news/2021/11/safeguards-15021-eu-amends-cosmetics-regulation-in-response-to-cmr-substances.

[16] [16] MEDICPRO. Lilial ban [EB/OL]. [2024-05-29]. https://medicpro.london/lilial-ban/.

[21] [21] IFRA. Guidance for the use of IFRA standards(Amendment 49)[EB/OL]. [2024-05-29]. https://ifrafragrance.org/docs/default-source/ifra-code-of-practice-and-standards/49th-amendment/ifra-49th-amendment-(att-01)---guidance-for-the-use-of-ifra-standardsa7006c445f36499bbb0eb141e8c0d4be.pdf?sfvrsn=7fb244c8_2.

[23] [23] IFRA. IFRA 49th amendment implementation & lilial (BMHCA) restrictions [EB/OL]. [2024-05-29]. https://suppliesforcandles.co.uk/candle-college/ifra-49th-amendment-implementation.

[24] [24] SFDA. Prohibited ingredients list [EB/OL]. [2024-05-29]. https://www.sfda.gov.sa/en/ProhibitedIngredientsList.

[25] [25] NPRA. HITS: 191426 cosmetic guidelines (annex I - VII)[S].(2023)[2024-05-29]. https://www.npra.gov.my/index.php/en/cosmetics-guideline-annex-i-vii.

[26] [26] FDA. Cosmetic labeling [EB/OL]. [2024-05-29]. https://www.ecfr.gov/current/title-21/chapter-I/subchapter-G/part-701/subpart-A.

[27] [27] EWG. Lilial [EB/OL]. [2024-05-29]. https://www.ewg.org/skindeep/ingredients/700872-LILIAL/.

[30] [30] ???????. ??? ?? [EB/OL]. [2024-05-29]. https://kcia.or.kr/cid/search/ingd_view.php?no=608.

[31] [31] ????????. ?????????? ?2019-129?, 043-719-3410 ??? ?? ?? ???? ? ???? ???? ??? ?? ??[S]. (2019) [2024-05-29]. https://law.go.kr/LSW/admRulInfoP.do?admRulSeq=2100000184611#AJAX.

[33] [33] AL-MUSSALLAM A S, BAWAZIR A T, ALSHATHRI R S,et al. Optimization of a gas chromatography-mass spectrometry (GCMS) method for detecting 28 allergens in various personal care products [J]. Cosmetics, 2023, 10(3). https://doi.org/10.3390/cosmetics10030091.

[36] [36] LAMAS J P, SANCHEZ-PRADO L, GARCIA-JARES C, et al. Development of a solid phase dispersion-pressurized liquid extraction method for the analysis of suspected fragrance allergens in leave-on cosmetics [J]. Journal of Chromatography. A, 2010, 1217(52): 8087-8094.

[38] [38] JABLONSK E, MCHAL Z, KKOVSK B, et al. Toxicological investigation of lilial [J]. Scientific Reports, 2023, 13(1): 18536.

[39] [39] ECHA. Opinion proposing harmonised classification and labelling at EU level of 2-(4-tert-butylbenzyl)propionaldehyde[EB/OL]. (2019) [2024-05-29]. https://echa.europa.eu/documents/10162/c9df2c0d-aa73-6146-c5a9-f742f487a479.

[40] [40] MURAWSKI A, FIEDLER N, SCHMIED-TOBIES M I H, et al. Metabolites of the fragrance 2-(4-tert-butylbenzyl) propionaldehyde (lysmeral) in urine of children and adolescents in Germany-human biomonitoring results of the German environmental survey 2014—2017 (GerES V) [J]. International Journal of Hygiene and Environmental Health, 2020, 229: 113594.

[41] [41] HARENG L, SCHUSTER P, HAAKE V, et al. Towards the mechanism of spermatotoxicity of p-tert-butyl-alpha-methylhy?drocinnamic aldehyde: inhibition of late stage ex-vivo spermatogenesis in rat seminiferous tubule cultures by Para-tert-butyl-benzoic acid [J]. Archives of Toxicology, 2023, 97(1): 279-294.

[42] [42] YAN G, ROSE J, ELLISON C, et al. Refine and strengthen SAR-based read-across by considering bioactivation and modes of action [J]. Chemical Research in Toxicology, 2023, 36(9): 1532-1548.

[43] [43] LAUE H, KERN S, BADERTSCHER R P, et al. p-Alkyl-benzoyl-CoA conjugates as relevant metabolites of aromatic aldehydes with rat testicular toxicity-studies leading to the design of a safer new fragrance chemical [J]. Toxicological Sciences, 2017, 160(2): 244-255.

[44] [44] PLUYM N, KRNAC D, GILCH G, et al. A liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the human biomonitoring of non-occupational exposure to the fragrance 2-(4-tert-butylbenzyl) propionaldehyde (lysmeral) [J]. Analytical and Bioanalytical Chemistry, 2016, 408(21): 5873-5882.