Acta Laser Biology Sinica, Volume. 30, Issue 4, 348(2021)

Analysis of the Role of Human GLTP in the Initiation and Progression of Pancreatic Adenocarcinoma and Its Epigenetic Regulation Mechanisms Based on Bioinformatics Methods

MA Meiyan1,2, JI Shenying1,3, ZHANG Xiangyu1,3, LU Mengyun1,3, and ZOU Xianqiong1,2、*
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    References(26)

    [1] [1] KAMLEKAR R K, DHIRENDRA K, GAO Y G, et al. The glycolipid transfer protein (GLTP) domain of phosphoinositol 4-phosphate adaptor protein-2 (FAPP2): structure drives preference for simple neutral glycosphingolipids[J]. Biochimica et Biophysica Acta, 2013, 1831(2): 417-427.

    [2] [2] ZOU X Q, GAO Y G, RUVOLO V R, et al. Human glycolipid transfer protein gene (GLTP) expression is regulated by Sp1 and Sp3: involvement of the bioactive sphingolipid ceramide[J]. Journal of Biological Chemistry, 2011, 286(2): 1301-1311.

    [3] [3] BSCHIR K. Perspectivism in current epigenetics[J]. European Journal for Philosophy of Science, 2020, 10(3): 369-398.

    [4] [4] MALININA L, SIMANSHU D K, ZHAI X, et al. Sphingolipid transfer proteins defined by the GLTP-fold[J]. Quarterly Reviews of Biophysics, 2015, 48(3): 281-322.

    [5] [5] OCHOA-LIZARRALDE B, GAO Y G, POPOV A N, et al. Structural analyses of 4-phosphate adaptor protein 2 yield mechanistic insightsinto sphingolipid recognitionby the glycolipid transfer protein family[J]. Journal of Biological Chemistry, 2018, 293(43): 16709-16723.

    [6] [6] MATTJUS P. Specificity of the mammalian glycolipid transfer proteins[J]. Chemistry and Physics of Lipids, 2016, 194: 72-78.

    [7] [7] YU J T, WEN J T, BIAO T. Integrated analysis of hub genes and pathways in esophageal carcinoma based on NCBI’s gene expression omnibus: a bioinformatics analysis[J]. Medical Science Monitor, 2020, 26: e923934.

    [8] [8] LARSSON C, CORDEDDU L, SIGGENS L, et al. Restoration of KMT2C/MLL3 in human colorectal cancer cells reinforces genome-wide H3K4me1 profiles and influences cell growth and gene expression[J]. Clinical Epigenetics, 2020, 12(1): 333-339.

    [9] [9] LOCAL A, HUANG H, ALBUQUERQUE C P. Identification of H3K4me1-associated proteins at mammalian enhancers[J]. Nature Genetics, 2018, 50(1): 73-82.

    [10] [10] HOWE F S, FISCHL H, MURRAY S C, et al. Is H3K4me3 instructive for transcription activation[J]. Bioessays, 2017, 39(1): 1-12.

    [12] [12] HUANG X, YAN J, ZHANG M. Targeting epigenetic crosstalk as a therapeutic strategy for EZH2-aberrant solid tumors[J]. Cell, 2018, 175(1): 186-199.

    [15] [15] TANG Z, LI C, KANG B, et al. GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses[J]. Nucleic Acids Research, 2017, 45(W1): W98-W102.

    [16] [16] CERAMI E, GAO J, DOGRUSOZ U, et al. The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data[J]. Cancer Discovery, 2012, 2(5): 401-404.

    [17] [17] DíEZ-VILLANUEVA A, MALLONA I, PEINADO M A. Wanderer, an interactive viewer to explore DNA methylation and gene expression data in human cancer[J]. Epigenetics Chromatin, 2015, 8: 22.

    [18] [18] KAROLCHIK D, BAERTSCH R, DIEKHANS M, et al. The UCSC genome browser database[J]. Nucleic Acids Research, 2003, 31(1): 51-54.

    [19] [19] JEGGARI A, MARKS D S, LARSSON E. MiRcode: a map of putative microRNA target sites in the long non-coding transcriptome[J]. Bioinformatics, 2012, 28(15): 2062-2063.

    [20] [20] VLACHOS I S, HATZIGEORGIOU A G. Functional analysis of miRNAs using the DIANA tools online suite[J]. Methods in Molecular Biology, 2017, 1517: 25-50.

    [21] [21] SHANNON P, MARKIEL A, OZIER O, et al. Cytoscape: a software environment for integrated models of biomolecular interaction networks[J]. Genome Research, 2003, 13(11): 2498-2504.

    [22] [22] ZHOU L, LIANG X, ZHANG L, et al. MiR-27a-3p functions as an oncogene in gastric cancer by targeting BTG2[J]. Oncotarget, 2016, 7(32): 51943-51954.

    [23] [23] WADE S M, OHNESORGE N, MCLOUGHLIN H, et al. Dysregulated miR-125a promotes angiogenesis through enhanced glycolysis[J]. EBioMedicine, 2019, 47: 402-413.

    [24] [24] HU Z, GUO J, ZHAO M, et al. Predictive values of miR-129 and miR-139 for efficacy on patients with prostate cancer after chemotherapy and prognostic correlation[J]. Oncology Letters, 2019, 18(6): 6187-6195.

    [25] [25] YU D, YUE W, XUE W, et al. Effects of long non-coding RNA myocardial infarction-associated transcript on retinal neovascularization in a newborn mouse model of oxygen-induced retinopathy[J]. Neural Regeneration Research, 2021, 16(9): 1877-1881.

    [26] [26] PENG H, PAN X, SU Q, et al. MiR-372-3p promotes tumor progression by targeting LATS2 in colorectal cancer[J]. European Review for Medical and Pharmacological Sciences, 2019, 23(19): 8332-8344.

    [27] [27] CHEN X, LOU N, RUAN A, et al. MiR-224/miR-141 ratio as a novel diagnostic biomarker in renal cell carcinoma[J]. Oncology Letters, 2018, 16(2): 1666-1674.

    [28] [28] SHI L, FAN B, CHEN D, et al. Human cytomegalovirus protein UL136 activates the IL-6/STAT3 signal through miR-138 and miR-34c in gastric cancer cells[J]. International Journal of Clinical Oncology, 2020, 25(11): 1936-1944.

    [30] [30] SADAKIERSKA-CHUDY A. MicroRNAs: diverse mechanisms of action and their potential applications as cancer Epi-Therapeutics[J]. Biomolecules, 2020, 10(9): 1-21.

    CLP Journals

    [1] ZHANG Xiangyu, ZHANG Yanqun, LU Mengyun, HU Yihong, HAN Yucheng, ZOU Xianqiong. The Expression and Clinical Significance of GLTPD2 in Hepatocellular Carcinoma Analyzed with Multiple Databases[J]. Acta Laser Biology Sinica, 2022, 31(1): 27

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    MA Meiyan, JI Shenying, ZHANG Xiangyu, LU Mengyun, ZOU Xianqiong. Analysis of the Role of Human GLTP in the Initiation and Progression of Pancreatic Adenocarcinoma and Its Epigenetic Regulation Mechanisms Based on Bioinformatics Methods[J]. Acta Laser Biology Sinica, 2021, 30(4): 348

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    Paper Information

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    Received: Mar. 16, 2021

    Accepted: --

    Published Online: Sep. 12, 2021

    The Author Email: Xianqiong ZOU (zouxq019@glmc.edu.cn)

    DOI:10.3969/j.issn.1007-7146.2021.04.008

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