[1] [1] Siegel RL, Miller KD, Wagle NS, et al. Cancer statistics, 2023[J]. CA Cancer J Clin, 2023, 73(1): 17-48.

[2] [2] Thai AA, Solomon BJ, Sequist LV, etal. Lung cancer[J]. Lancet, 2021, 398(10299): 535-554.

[3] [3] Arbour KC, Riely GJ. Systemic therapy for locally advanced and metastatic non-small cell lung cancer: a review[J]. JAMA, 2019, 322(8): 764-774.

[4] [4] Reyes-Hernndez OD, Figueroa-Gonzlez G, Quintas-Granados LI, et al. 3, 3′-Diindolylmethane and indole-3-carbinol: potential therapeutic molecules for cancer chemoprevention and treatment via regulating cellular signaling pathways[J]. Cancer Cell Int, 2023, 23(1): 180.

[5] [5] Xiang F, Zhu Z, Zhang M, et al. 3, 3′-diindolylmethane enhances paclitaxel sensitivity by suppressing DNMT1-mediated KLF4 methylation in breast cancer[J]. Front Oncol, 2021, 11: 627856.

[6] [6] Tsao CW, Li JS, Lin YW, et al. Regulation of carcinogenesis and mediation through Wnt/-catenin signaling by 3, 3′-diindolylmethane in an enzalutamide-resistant prostate cancer cell line[J]. Sci Rep, 2021, 11(1): 1239.

[7] [7] Ye Y, Ye F, Li X, et al. 3, 3′-Diindolylmethane exerts antiproliferation and apoptosis induction by TRAF2-p38 axis in gastric cancer[J]. Anticancer Drugs, 2021, 32(2): 189-202.

[9] [9] Zhang J, Zou S, Zhang Y, et al. 3, 3′-Diindolylmethane enhances fluorouracil sensitivity via inhibition of pyrimidine metabolism in colorectal cancer[J]. Metabolites, 2022, 12(5): 410.

[10] [10] Dixon SJ, Lemberg KM, Lamprecht MR, etal. Ferroptosis: an iron-dependent form of nonapoptotic cell death[J]. Cell, 2012, 149(5): 1060-1072.

[11] [11] Li J, Cao F, Yin HL, et al. Ferroptosis: past, present and future[J]. Cell Death Dis, 2020, 11(2): 88.

[13] [13] Zhang C, Liu X, Jin S, et al. Ferroptosis in cancer therapy: a novel approach to reversing drug resistance[J]. Mol Cancer, 2022, 21(1): 47.

[16] [16] Friedmann Angeli JP, Krysko DV, Conrad M. Ferroptosis at the crossroads of cancer-acquired drug resistance and immune evasion[J]. Nat Rev Cancer, 2019, 19(7): 405-414.

[17] [17] Ye Y, Li X, Feng G, et al. 3, 3′-Diindolylmethane induces ferroptosis by BAP1-IP3R axis in BGC-823 gastric cancer cells[J]. Anticancer Drugs, 2022, 33(4): 362-370.

[18] [18] Guo C, Ma Z, Tao X, et al. Therapeutic time window of sodium of Danshensu on cerebral ischemia and its mechanism of inhibiting oxidative stress and ferroptosis through Nrf2 pathway[J]. Brain Res Bull, 2025, 227: 111396.

[19] [19] Chen H, Peng F, Xu J, et al. Increased expression of GPX4 promotes the tumorigenesis of thyroid cancer by inhibiting ferroptosis and predicts poor clinical outcomes[J]. Aging (Albany NY), 2023, 15(1): 230-245.

[20] [20] Xiao C, Fu X, Wang Y, et al. Transferrin receptor regulates malignancies and the stemness of hepatocellular carcinoma-derived cancer stem-like cells by affecting iron accumulation[J]. PLoS One, 2020, 15(12): e0243812.

[21] [21] Di Y, Zhang X, Wen X, et al. MAPK signaling-mediated RFNG phosphorylation and nuclear translocation restrain oxaliplatin-induced apoptosis and ferroptosis[J]. Adv Sci, 2024, 11(38): e2402795.

[22] [22] Chen TC, Chuang JY, Ko CY, et al. AR ubiquitination induced by the curcumin analog suppresses growth of temozolomide-resistant glioblastoma through disrupting GPX4-mediated redox homeostasis[J]. Redox Biol, 2020, 30: 101413.

[23] [23] Markowitsch SD, Schupp P, Lauckner J, etal. Artesunate inhibits growth of sunitinib-resistant renal cell carcinoma cells through cell cycle arrest and induction of ferroptosis[J]. Cancers, 2020, 12(11): 3150.

[24] [24] Wang X, Zhou Y, Ning L, et al. Knockdown of ANXA10 induces ferroptosis by inhibiting autophagy-mediated TFRC degradation in colorectal cancer[J]. Cell Death Dis, 2023, 14(9): 588.

[25] [25] Chen X, Li J, Kang R, et al. Ferroptosis: machinery and regulation[J]. Autophagy, 2021, 17(9): 2054-2081.

[26] [26] Wei R, Zhao Y, Wang J, et al. Tagitinin C induces ferroptosis through PERK-Nrf2-HO-1 signaling pathway in colorectal cancer cells[J]. Int J Biol Sci, 2021, 17(11): 2703-2717.

[27] [27] Xu X, Zhang X, Wei C, et al. Targeting SLC7A11 specifically suppresses the progression of colorectal cancer stem cells via inducing ferroptosis[J]. Eur J Pharm Sci, 2020, 152: 105450.