Journal of Tongji University(Medical Science), Volume. 46, Issue 3, 470(2025)

Combined antimicrobial activity of D-phenyllactic acid and hydroxypropyl-β-cyclodextrin against Fusobacterium nucleatum and its molecular mechanisms

YAN Xiaoli1, ZHAN Duanhong2, SHENG Linfeng2, HUANG Xiawei2, DU Chenshuo2, and HU Zihao2
Author Affiliations
  • 1Teaching Laboratory Center, School of Medicine, Tongji University, Shanghai 200331, China
  • 2Department of Clinical Medicine, School of Medicine, Tongji University, Shanghai 200331, China
  • show less
    References(13)

    [1] [1] PIGNATELLI P, NUCCIO F, PIATTELLI A, et al. The role ofFusobacterium nucleatumin oral and colorectal carcinogenesis[J]. Microorganisms, 2023, 11(9): 2358.

    [3] [3] PARHI L, ALON-MAIMON T, SOL A, et al. Breast cancer colonization byFusobacterium nucleatumaccelerates tumor growth and metastatic progression[J]. Nat Commun, 2020, 11(1): 3259.

    [4] [4] KOSTIC A D, CHUN E, ROBERTSON L, et al.Fusobacterium nucleatumpotentiates intestinal tumorigenesis and modulates the tumor-immune microenvironment[J]. Cell Host Microbe, 2013, 14(2): 207-215.

    [5] [5] HAN Y W.Fusobacterium nucleatum: a commensal-turned pathogen[J]. Curr Opin Microbiol, 2015, 23: 141-147.

    [6] [6] RICKARD A H, GILBERT P, HIGH N J, et al. Bacterial coaggregation: an integral process in the development of multi-species biofilms[J]. Trends Microbiol, 2003, 11(2): 94-100.

    [7] [7] UDAYASURYAN B, AHMAD R N, NGUYEN T T D, et al.Fusobacterium nucleatuminduces proliferation and migration in pancreatic cancer cells through host autocrine and paracrine signaling[J]. Sci Signal, 2022, 15(756): eabn4948.

    [8] [8] WU H, GUANG C, ZHANG W, et al. Recent development of phenyllactic acid: physicochemical properties, biotechnological production strategies and applications[J]. Crit Rev Biotechnol, 2023, 43(2): 293-308.

    [9] [9] NING Y W, YAN A H, YANG K, et al. Antibacterial activity of phenyllactic acid againstListeria monocytogenesandEscherichia coliby dual mechanisms[J]. Food Chem, 2017, 228: 533-540.

    [10] [10] YU J Y, HONG C L, YIN L F, et al. Antimicrobial activity of phenyllactic acid againstKlebsiella pneumoniaeand its effect on cell wall membrane and genomic DNA[J]. Braz J Microbiol, 2023, 54(4): 3245-3255.

    [13] [13] FRIJLINK H W, VISSER J, HEFTING N R, et al. The pharmacokinetics of beta-cyclodextrin and hydroxypropyl-beta-cyclodextrin in the rat[J]. Pharm Res, 1990, 7(12): 1248-1252.

    [14] [14] DIEULEVEUX V, LEMARINIER S, GUGUEN M. Antimicrobial spectrum and target site of D-3-phenyllactic acid[J]. Int J Food Microbiol, 1998, 40(3): 177-183.

    [15] [15] GOULD S, SCOTT R C. 2-hydroxypropyl-beta-cyclo-dextrin (HP-beta-CD): a toxicology review[J]. Food Chem Toxicol, 2005, 43(10): 1451-1459.

    [16] [16] YANG M F, TIAN T, FANG Y X, et al. Reducing lead toxicity of perovskite solar cells with a built-in supramolecular complex[J]. Nat Sustain, 2023, 6(11): 1455-1464.

    Tools

    Get Citation

    Copy Citation Text

    YAN Xiaoli, ZHAN Duanhong, SHENG Linfeng, HUANG Xiawei, DU Chenshuo, HU Zihao. Combined antimicrobial activity of D-phenyllactic acid and hydroxypropyl-β-cyclodextrin against Fusobacterium nucleatum and its molecular mechanisms[J]. Journal of Tongji University(Medical Science), 2025, 46(3): 470

    Download Citation

    EndNote(RIS)BibTexPlain Text
    Save article for my favorites
    Paper Information

    Category:

    Received: Sep. 28, 2024

    Accepted: Aug. 26, 2025

    Published Online: Aug. 26, 2025

    The Author Email:

    DOI:10.12289/j.issn.2097-4345.24400

    Topics