Acta Laser Biology Sinica, Volume. 34, Issue 3, 214(2025)

Research Progress on the Relationship Between Microbiome-gut-heart Axis and Cardiovascular Disease

LYU Dan1,2, CHEN Yong1, WU Xiushan3, TAN Zhixia2,4, LUO Jie1, CAI Xiuyi2, NING Siyi1, and YE Xiangli2,3、*
Author Affiliations
  • 1Department of Clinical Laboratory, Changsha Stomatological Hospital, Hunan 410004, China
  • 2Hunan Normal University Health Science Center, Hunan 410013, China
  • 3Hunan Normal University The Center for Heart Development, College of Life Sciences, Hunan 410081, China
  • 4Department of Clinical Laboratory, the Ninth Hospital of Changsha, Hunan 410004, China
  • show less
    References(37)

    [2] [2] HEMMATI M, KASHANIPOOR S, MAZAHERI P,et al. Importance of gut microbiota metabolites in the development of cardiovascular diseases (CVD)[J]. Life Sciences, 2023, 329: 121947.

    [3] [3] SHARIFF S, KWAN S H A, PARAG S N,et al.Unlocking the gut-heart axis: exploring the role of gut microbiota in cardiovascular health and disease[J]. Annals of Medicine and Surgery, 2024, 86(5): 2752-2758.

    [5] [5] MANOLIS A A, MANOLIS T A, MELITA H,et al. Gut microbiota and cardiovascular disease: symbiosis versus dysbiosis[J]. Current Medicinal Chemistry, 2022, 29(23): 4050-4077.

    [6] [6] DE VOS W M, TILG H, VAN H M,et al. Gut microbiome and health: mechanistic insights[J]. Gut, 2022, 71(5): 1020-1032.

    [7] [7] BARTOLOMAEUS H, MCPARLAND V, WILCK N,et al. Gut-heart axis: how gut bacteria influence cardiovascular diseases[J]. Herz, 2020, 45(2): 134-141.

    [8] [8] GLORIEU G, NIGAM S K, VANHOLDER R,et al. Role of the microbiome in gut-heart-kidney cross talk[J]. Circulation Research, 2023, 132(8): 1064-1083.

    [9] [9] JIE Z, XIA H, ZHONG S L,et al. The gut microbiome in atherosclerotic cardiovascular disease[J]. Nature Communications, 2017, 8: 845.

    [10] [10] DESAI D, DESAI A, JAMIL A,et al. Re-defining the gut heart axis: a systematic review of the literature on the role of gut microbial dysbiosis in patients with heart failure[J]. Cureus, 2023, 15(2): e34902.

    [11] [11] MATSIRAS D, BEZATI S, VENTOUSLIS I,et al. Gut failure: a review of the pathophysiology and therapeutic potentials in the gut-heart axis[J]. Journal of Clinical Medicine, 2023, 12(7): 2567.

    [12] [12] AHLAWAT S, ASHA, SHARMA K K. Gut-organ axis: a microbial outreach and networking[J]. Letters in Applied Microbiology, 2021, 72(6): 636-668.

    [13] [13] VERHAAR B J H, PRODAN A, NIEUWDORP M,et al. Gut microbiota in hypertension and atherosclerosis: a review[J]. Nutrients, 2020, 12(10): 2982.

    [14] [14] YANG Z, WANG Q, LIU Y,et al. Gut microbiota and hypertension: association, mechanisms and treatment[J]. Clinical and Experimental Hypertension, 2023, 45(1): 2195135.

    [15] [15] YANG T, SANTISTEBAN M M, RODRIGUEZ V,et al. Gut dysbiosis is linked to hypertension[J]. Hypertension, 2015, 65: 1331-1340.

    [16] [16] YAN Q, GU Y, LI X,et al. Alterations of the gut microbiome in hypertension[J]. Frontiers in Cellular and Infection Microbiology, 2017, 7: 381.

    [17] [17] XU C, MARQUES F Z. How dietary fibre, acting via the gut microbiome, lowers blood pressure[J]. Current Hypertension Reports, 2022, 24(11): 509-521.

    [18] [18] REYNOLDS A N, AKERMAN A, KUMAR S,et al. Dietary fibre in hypertension and cardiovascular disease management: systematic review and meta-analyses[J]. BMC Medicine, 2022, 20(1): 139.

    [19] [19] LYMPEROPOULOS A, SUSTER M S, BORGES J I. Short-chain fatty acid receptors and cardiovascular function[J]. International Journal of Molecular Sciences, 2022, 23(6): 3303.

    [20] [20] PLUZNICK J L, PROTZKO R J, GEVORGYAN H,et al. Olfactory receptor responding to gut microbiota-derived signals plays a role in renin secretion and blood pressure regulation[J]. Proceedings of the National Academy of Sciences of the United States of America, 2013, 110(11): 4410-4415.

    [21] [21] SUGANYA K, SON T, KIM K W,et al. Impact of gut microbiota: how it could play roles beyond the digestive system on development of cardiovascular and renal diseases[J]. Microbial Pathogenesis, 2021, 152: 104583.

    [22] [22] LU J, JIN X, YANG S,et al. Immune mechanism of gut microbiota and its metabolites in the occurrence and development of cardiovascular diseases[J]. Frontiers in Microbiology, 2022, 13: 1034537.

    [23] [23] GUASTI L, GALLIAZZO S, MOLARO M,et al. TMAO as a biomarker of cardiovascular events: a systematic review and meta-analysis[J]. Internal and Emergency Medicine, 2021, 16(1): 201-207.

    [24] [24] ZHAO Y, WANG Z. Gut microbiome and cardiovascular disease[J]. Current Opinion in Cardiology, 2020, 35(3): 207-218.

    [25] [25] CHAN Y K, BRAR M S, KIRJAVAINEN P V,et al. High fat diet induced atherosclerosis is accompanied with low colonic bacterial diversity and altered abundances that correlates with plaque size, plasma A-FABP and cholesterol: a pilot study of high fat diet and its intervention withLactobacillus rhamnosusGG (LGG) or telmisartan inApoE-/- mice[J]. BMC Microbiology, 2016, 16: 264.

    [26] [26] MAMIC P, CHAIKIJURAJAI T, TANG W H W. Gut microbiome—a potential mediator of pathogenesis in heart failure and its comorbidities: state-of-the-art review[J]. Journal of Molecular and Cellular Cardiology, 2021, 152: 105-117.

    [27] [27] PASINI E, AQUILANI R, TESTA C,et al. Pathogenic gut flora in patients with chronic heart failure[J]. JACC Heart Failure, 2016, 4(3): 220-227.

    [28] [28] LI S, KARARIGAS G. Role of biological sex in the cardiovascular-gut microbiome axis[J]. Frontiers in Cardiovascular Medicine, 2022, 8: 759735.

    [29] [29] HERMISTON M L, GORDON J I. Inflammatory bowel disease and adenomas in mice expressing a dominant negative N-cadherin[J]. Science, 1995, 270(5239): 1203-1207.

    [30] [30] MAGADUM A, KISHORE R. Cardiovascular manifestations of COVID-19 infection[J]. Cells, 2020, 9(11): 2508.

    [31] [31] MASHAQI S, KALLAMADI R, MATTA A,et al. Obstructive sleep apnea as a risk factor for COVID-19 severity: the gut microbiome as a common player mediating systemic inflammation via gut barrier dysfunction[J]. Cells, 2022, 11(9): 1569.

    [32] [32] HOEL H, HEGGELUND L, REIKVAN D H,et al. Elevated markers of gut leakage and inflammasome activation in COVID-19 patients with cardiac involvement[J]. Journal of Internal Medicine, 2021, 289: 523-531.

    [33] [33] CHAKRABORY C, SHARMA A R, BHATTACHARYA M,et al. Altered gut microbiota patterns in COVID-19: markers for inflammation and disease severity[J]. World Journal of Gastroenterology, 2022, 28(25): 2802-2822.

    [34] [34] HU X F, ZHANG W Y, WEN Q,et al. Fecal microbiota transplantation alleviates myocardial damage in myocarditis by restoring the microbiota composition[J]. Pharmacological Research, 2019, 139: 412-421.

    [35] [35] DURGAN D J, GANESH B P, COPE J L,et al. Role of the gut microbiome in obstructive sleep apnea-induced hypertension[J]. Hypertension, 2016, 67: 469-474.

    [36] [36] WU H, CHIOU J. Potential benefits of probiotics and prebiotics for coronary heart disease and stroke[J]. Nutrients, 2021, 13(8): 2878.

    [37] [37] AFUS A, CLEMENT K, SOKOL H. Gut microbiota-derived metabolites as central regulators in metabolic disorders[J]. Gut, 2021, 70(6): 1174-1182.

    [38] [38] DE FILIPPIS F, PELLEGRINI N, VANNINI L,et al. High-level adherence to a mediterranean diet beneficially impacts the gut microbiota and associated metabolome[J]. Gut, 2016, 65(11): 1812-1821.

    [39] [39] FILIPPOU C, THOMOPOULOS C, KONSTANTINIDIS D,et al. Dash vs. mediterranean diet on a salt restriction background in adults with high normal blood pressure or grade 1 hypertension: a randomized controlled trial[J]. Clinical Nutrition, 2023, 42(10): 1807-1816.

    Tools

    Get Citation

    Copy Citation Text

    LYU Dan, CHEN Yong, WU Xiushan, TAN Zhixia, LUO Jie, CAI Xiuyi, NING Siyi, YE Xiangli. Research Progress on the Relationship Between Microbiome-gut-heart Axis and Cardiovascular Disease[J]. Acta Laser Biology Sinica, 2025, 34(3): 214

    Download Citation

    EndNote(RIS)BibTexPlain Text
    Save article for my favorites
    Paper Information

    Category:

    Received: Aug. 22, 2024

    Accepted: Jul. 24, 2025

    Published Online: Jul. 24, 2025

    The Author Email: YE Xiangli (ye_xiangli@hunnu.edu.cn)

    DOI:10.3969/j.issn.1007-7146.2025.03.003

    Topics