Chinese Journal of Lasers, Volume. 51, Issue 15, 1507101(2024)

Development of Visible-Light OCT: A Review (Invited)

Weiye Song1,2、*, Zhengkai Yao1,2, Fuwang Wu1,2, Kaixuan Hu1,2, and Xianchun Jiang1,2
Author Affiliations
  • 1School of Mechanical Engineering, Shandong University, Jinan 250061, Shandong , China
  • 2Key Laboratory of High Efficiency and Clean Mechanical Manufacture of Ministry of Education, Shandong University, Jinan 250061, Shandong , China
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    Figures & Tables(9)
    Schematic diagram of the SLO guided Vis-OCT system[54]
    Schematic of the VN-OCT system[56]
    Overview of dual-channel Vis-OCT[64]. (a) Schematic of the system configuration. Three key enabling designs for full-range and wide-field imaging are: ① linear-in-K Vis-OCT spectrometer; ② per-A-line noise cancelation by a second spectrometer; ③ reference pathlength modulation. Summary of the imaging performance by three optical designs: (b) achieving 7.2 dB signal-to-noise ratio roll-off over the entire imaging range; (c) short-noise limited performance; (d) doubling the imaging depth range
    Averaged spectral intensity extracted from all identified arteries and veins[48]. (a) Spectral intensity from the visible wavelength band; (b) spectral intensity from the infrared band
    Illustration of RNFL thickness and VN ratio calculation[86]
    Imaging of mouse SC[92]. (a) 3D visualization of montage limbal images; (b) projected view of the entire SC and limbal microvascular network
    SLO and OCT images centered at the fovea[54]. (a)‒(b) En-face images of SLO and Vis-OCT; (c)‒(d) enlarged images from the squared area in Figs. (a) and (b); (e) cross-sectional Vis-OCT image from the position highlighted in (b) with all anatomical structures labeled; (f) cross-sectional image obtained from a commercial NIR-OCT system
    Human retinal oximetry on small vessels and capillaries by Vis-OCTA[49]. (a) Color-coded image of sO2 on arterioles, venules and capillaries at the perifoveal region; (b)‒(d) representative spectrograms from an arteriole, a venule and the capillary network from panel (a); (e)‒(g) measured spectra from all arterioles, venules, and capillary network, where the solid curves are the mean spectra from all the vessels in panel (a), and the capillary spectrum is averaged within the entire FOV
    • Table 1. Introduction to the branches of OCT technology

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      Table 1. Introduction to the branches of OCT technology

      Summary of main featuresOCT technical branchSummary of technology
      High resolutionVisible-light OCTImaging with light sources in the visible band allows for higher axial resolution and the ability to observe details that cannot be observed in infrared light[27]
      Adaptive optics OCTIt can measure and correct eye aberrations, improve lateral resolution, reduce speckle size and increase sensitivity to weak reflections[28]
      Wide spectrum OCTIt has a wide bandwidth and can recognize retinal structures at cellular and subcellular levels[29]
      Large imaging fieldsFull-field and dynamic full-field OCTAcquiring images with charge coupled device cameras in 2D en-face orientation at different depths for high resolution images at the cellular level[30-32]
      Wide-field OCTThree-dimensional retinal images can be obtained over a field-of-view of more than 70°[33]
      Functional imagingPolarization sensitive OCTIt can assess birefringence and thickness independently[14,34] and provide more molecular contrast than OCT[35]
      OCT angiographyIt is sensitive to motion contrast, enabling 3D visualization of blood flowing within vascular networks without the administration of intravenous contrast agents[36]

      Wide range of

      applicability

      Hand-held OCTMaking OCT systems smaller, lighter, and capable of scanning targets in a hand-held manner[37]
      Low-cost OCTThis significantly reduces the price of OCT and more people can benefit from this advanced medical technology[38]
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    Weiye Song, Zhengkai Yao, Fuwang Wu, Kaixuan Hu, Xianchun Jiang. Development of Visible-Light OCT: A Review (Invited)[J]. Chinese Journal of Lasers, 2024, 51(15): 1507101

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    Paper Information

    Category: Biomedical Optical Imaging

    Received: Feb. 28, 2024

    Accepted: Apr. 15, 2024

    Published Online: Jul. 16, 2024

    The Author Email: Weiye Song (songweiye@sdu.edu.cn)

    DOI:10.3788/CJL240634

    CSTR:32183.14.CJL240634

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