Chinese Journal of Lasers, Volume. 45, Issue 6, 0607004(2018)

Blood Flow Measurementwith Photoacoustic Microscopy and Optical Coherence Tomography

Liuhua Pan1,2, Xiangyang Zhang3, Zhongliang Li1,2, Nan Nan1, Yang Bu1,2, Yan Chen1,2, Xuan Wang1,2, and Xiangzhao Wang1,2、*
Author Affiliations
  • 1 Laboratory of Information Optics and Optoelectronic Technology, Shanghai Institute of Optics and Fine Mechanics,Chinese Academy of Sciences, Shanghai 201800, China
  • 2 University of Chinese Academy of Sciences, Beijing 100049, China
  • 3 School of Science, Jiangnan University, Wuxi, Jiangsu 214122, China
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    Absolute blood flow velocity and orientation are measured by a dual-mode imaging technology using photoacoustic microscopy and optical coherence tomography (PA/OCT). The blood flow velocity perpendicular to the direction of the probe beam is measured by photoacoustic correlation spectroscopy. The blood flow velocity parallel to the direction of the probe beam is measured by the Doppler OCT. Then the absolute velocity and orientation of blood flow are obtained. For the same fluid sample with different tilt angles, the standard deviation of the absolute blood flow velocity which is 1 mm·s -1 measured by PA/OCT is 0.02 mm·s -1 and the correlation coefficient between the blood flow orientation measured by PA/OCT and the actual flow orientation is 0.997. The experimental results show that the PA/OCT is suitable for measuring absolute blood flow velocity and orientation.

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    Liuhua Pan, Xiangyang Zhang, Zhongliang Li, Nan Nan, Yang Bu, Yan Chen, Xuan Wang, Xiangzhao Wang. Blood Flow Measurementwith Photoacoustic Microscopy and Optical Coherence Tomography[J]. Chinese Journal of Lasers, 2018, 45(6): 0607004

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    Paper Information

    Category: biomedical photonics and laser medicine

    Received: Jan. 3, 2018

    Accepted: --

    Published Online: Jul. 5, 2018

    The Author Email: Xiangzhao Wang (waz26267@siom.ac.cn)

    DOI:10.3788/CJL201845.0607004

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