ObjectiveTo investigate the influencing factors of weight in hospitalized patients with schizophrenia (SCZ).MethodsThe demographic data, physical measurement indicators and laboratory nutritional metabolism indicators from 401 hospitalized SCZ patients hospitalized in Shanghai Putuo Mental Health Center were collected. The patients were divided into 4 groups according to body mass index (BMI): low weight group, normal weight group, overweight group, and obesity group. The general information and nutritional indicators of the 4 groups were compared, and the risk factors for abnormal weight in SCZ patients were analyzed too.ResultsAmong the hospitalized SCZ patients, 31 cases were underweight, accounting for 7.7% (31/401), 158 cases had normal weight, accounting for 39.4% (158/401), 134 cases were overweight, accounting for 33.4% (134/401); 78 cases were obese, accounting for 19.5% (78/401). There was no statistically significant differences in gender, marriage status, educational level, comorbidities, smoking history, alcohol consumption history, albumin, total cholesterol, fasting blood glucose and low-density lipoprotein among the 4 groups (all P>0.05). There were statistically significant differences in age, course of disease, length of hospital stay, systolic and diastolic blood pressure, history of antipsychotic drugs using, hemoglobin, lymphocyte counts, red blood cell, white blood cell, total protein, prealbumin, triglycerides, high-density lipoprotein and uric acid among the 4 groups (all P<0.05). Multivariate regression analysis showed that referring to the patients with normal weight, low systolic blood pressure was a risk factor for low weight (P<0.05); young age, high red blood cell, and high triglyceride were risk factors for overweight (all P<0.05); young age, short hospital stay, high systolic blood pressure, high red blood cell, high triglyceride, low high-density lipoprotein and combined use of antipsychotic drugs were risk factors for obesity (all P<0.05).ConclusionSCZ patients often experience abnormal weight, mainly overweight and obesity. Early attention, targeted and reasonable nutritional interventions should be provided to reduce the incidence of complications in SCZ patients, improve quality of life, shorten hospital stay, and reduce treatment costs.