Establishment of a Rat Model of Alzheimer's Disease by Introducing Human Triple Mutant APP Gene into Hippocampus via Brain Stereotactic Technology

XIAO Linlin; YANG Yixuan; LI Shanshan; LUO Lanshiyu; YIN Siwei; SUN Juming; SHI Wei; OUYANG Yiqiang; LI Xiyi

doi:10.12300/j.issn.1674-5817.2025.030

Laboratory Animal and Comparative Medicine, Volume. 45, Issue 3, 269(2025)

Establishment of a Rat Model of Alzheimer's Disease by Introducing Human Triple Mutant APP Gene into Hippocampus via Brain Stereotactic Technology

XIAO Linlin^1,2, YANG Yixuan^1,2, LI Shanshan^1,2, LUO Lanshiyu^1,2, YIN Siwei^1,2, SUN Juming¹, SHI Wei¹, OUYANG Yiqiang¹, and LI Xiyi^3、*

Author Affiliations

¹Laboratory Animal Center, Guangxi Medical University, Nanning 530021, China

²School of Basic Medical Sciences, Guangxi Medical University, Nanning 530021, China

³School of Public Health, Guangxi Medical University, Nanning 530021, China

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XIAO Linlin, YANG Yixuan, LI Shanshan, LUO Lanshiyu, YIN Siwei, SUN Juming, SHI Wei, OUYANG Yiqiang, LI Xiyi. Establishment of a Rat Model of Alzheimer's Disease by Introducing Human Triple Mutant APP Gene into Hippocampus via Brain Stereotactic Technology[J]. Laboratory Animal and Comparative Medicine, 2025, 45(3): 269

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Received: Mar. 1, 2025

Accepted: Aug. 26, 2025

Published Online: Aug. 26, 2025

The Author Email: LI Xiyi (leeciyee@163.com)

DOI:10.12300/j.issn.1674-5817.2025.030

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