[1] [1] ENJALBERT F, RAPIOR S, NOUGUIER-SOUL J, et al. Treatment of amatoxin poisoning: 20-year retrospective analysis[J]. J Toxicol Clin Toxicol, 2002, 40(6): 715−757. doi: 10.1081/CLT-120014646.

[3] [3] TAVASSOLI M, AFSHARI A, ARSENE A L, et al. Toxicological profile ofAmanita virosa— A narrative review[J]. Toxicol Rep, 2019, 6: 143−150. doi: 10.1016/j.toxrep.2019.01.002.

[4] [4] ZHELEVA A, TOLEKOVA A, ZHELEV M, et al. Free radical reactions might contribute to severe alpha amanitin hepatotoxicity — A hypothesis[J]. Med Hypotheses, 2007, 69(2): 361−367. doi: 10.1016/j.mehy.2006.10.066.

[5] [5] WANG M, CHEN Y, GUO Z, et al. Changes in the mitochondrial proteome in human hepatocytes in response to alpha-amanitin hepatotoxicity[J]. Toxicon, 2018, 156: 34−40. doi: 10.1016/j.toxicon.2018.11.002.

[6] [6] MAGDALAN J, OSTROWSKA A, PIOTROWSKA A, et al. -Amanitin induced apoptosis in primary cultured dog hepatocytes[J]. Folia Histochem Cytobiol, 2010, 48(1): 58−62. doi: 10.2478/v10042-010-0010-6.

[7] [7] JIANG L, KON N, LI T, et al. Ferroptosis as a p53-mediated activity during tumour suppression[J]. Nature, 2015, 520(7545): 57−62. doi: 10.1038/nature14344.

[8] [8] TANG D, CHEN X, KANG R, et al. Ferroptosis: Molecular mechanisms and health implications[J]. Cell Res, 2021, 31(2): 107−125. doi: 10.1038/s41422-020-00441-1.

[9] [9] DIXON S J, LEMBERG K M, LAMPRECHT M R, et al. Ferroptosis: An iron-dependent form of nonapoptotic cell death[J]. Cell, 2012, 149(5): 1060−1072. doi: 10.1016/j.cell.2012.03.042.

[10] [10] LIANG D, FENG Y, ZANDKARIMI F, et al. Ferroptosis surveillance independent of GPX4 and differentially regulated by sex hormones[J]. Cell, 2023, 186(13): 2748−2764.e22. doi: 10.1016/j.cell.2023.05.003.

[11] [11] DONG H, QIANG Z, CHAI D, et al. Nrf2 inhibits ferroptosis and protects against acute lung injury due to intestinal ischemia reperfusion via regulating SLC7A11 and HO-1[J]. Aging (Albany NY), 2020, 12(13): 12943−12959. doi: 10.18632/aging.103378.

[12] [12] WANG H, YANG G, ZHANG X, et al. Cannabidiol protects the liver from -Amanitin-induced apoptosis and oxidative stress through the regulation of Nrf2[J]. Food Chem Toxicol, 2023, 182: 114196. doi: 10.1016/j.fct.2023.114196.

[13] [13] XU Y, WANG S W, LEUNG C K, et al. -Amanitin induces autophagy through AMPK-mTOR-ULK1 signaling pathway in hepatocytes[J]. Toxicol Lett, 2023, 383: 89−97. doi: 10.1016/j.toxlet.2023.06.004.

[14] [14] ZHAO J, CAO M, ZHANG J, et al. Pathological effects of the mushroom toxin alpha-amanitin on BALB/c mice[J]. Peptides, 2006, 27(12): 3047−3052. doi: 10.1016/j.peptides.2006.08.015.

[15] [15] THIEL K, SCHENK M, SIPOS B, et al. Acute liver failure after amanitin poisoning: A porcine model to detect prognostic markers for liver regeneration[J]. Hepatol Int, 2014, 8(1): 128−136. doi: 10.1007/s12072-013-9491-7.

[16] [16] KARLSON-STIBER C, PERSSON H. Cytotoxic fungi — An overview[J]. Toxicon, 2003, 42(4): 339−349. doi: 10.1016/s0041-0101(03)00238-1.

[17] [17] BUSHNELL D A, CRAMER P, KORNBERG R D. Structural basis of transcription: -Amanitin-RNA polymerase Ⅱ cocrystal at 2.8 resolution[J]. Proc Natl Acad Sci USA, 2002, 99(3): 1218−1222. doi: 10.1073/pnas.251664698.

[18] [18] LEIST M, GANTNER F, NAUMANN H, et al. Tumor necrosis factor-induced apoptosis during the poisoning of mice with hepatotoxins[J]. Gastroenterology, 1997, 112(3): 923−934. doi: 10.1053/gast.1997.v112.pm9041255.

[19] [19] LEU J I, GEORGE D L. Hepatic IGFBP1 is a prosurvival factor that binds to BAK, protects the liver from apoptosis, and antagonizes the proapoptotic actions of p53 at mitochondria[J]. Genes Dev, 2007, 21(23): 3095−3109. doi: 10.1101/gad.1567107.

[20] [20] TARANGELO A, MAGTANONG L, BIEGING-ROLETT K T, et al. p53 suppresses metabolic stress-induced ferroptosis in cancer cells[J]. Cell Rep, 2018, 22(3): 569−575. doi: 10.1016/j.celrep.2017.12.077.

[21] [21] JIANG X, STOCKWELL B R, CONRAD M. Ferroptosis: Mechanisms, biology and role in disease[J]. Nat Rev Mol Cell Biol, 2021, 22(4): 266−282. doi: 10.1038/s41580-020-00324-8.

[23] [23] SPINELLI J B, HAIGIS M C. The multifaceted contributions of mitochondria to cellular metabolism[J]. Nat Cell Biol, 2018, 20(7): 745−754. doi: 10.1038/s41556-018-0124-1.

[24] [24] FRIEDMANN ANGELI J P, SCHNEIDER M, PRONETH B, et al. Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice[J]. Nat Cell Biol, 2014, 16(12): 1180−1191. doi: 10.1038/ncb3064.

[25] [25] DING Y, CHEN X, LIU C, et al. Identification of a small molecule as inducer of ferroptosis and apoptosis through ubiquitination of GPX4 in triple negative breast cancer cells[J]. J Hematol Oncol, 2021, 14(1): 19. doi: 10.1186/s13045-020-01016-8.

[26] [26] KOPPULA P, ZHANG Y, ZHUANG L, et al. Amino acid transporter SLC7A11/xCT at the crossroads of regulating redox homeostasis and nutrient dependency of cancer[J]. Cancer Commun (Lond), 2018, 38(1): 12. doi: 10.1186/s40880-018-0288-x.

[27] [27] ZHANG Y, TAN H, DANIELS J D, et al. Imidazole ketone erastin induces ferroptosis and slows tumor growth in a mouse lymphoma model[J]. Cell Chem Biol, 2019, 26(5): 623−633.e9. doi: 10.1016/j.chembiol.2019.01.008.