[1] [1] LIU P, ZHAO H, LUO Y. Anti-aging implications of Astra- galus membranaceus (huangqi): a well-known chinese tonic[J]. Aging and Disease, 2017, 8(6): 868-886.

[2] [2] ZHU H, ZHANG Y, YE G, et al. In vivo and in vitro antiviral activities of calycosin-7-O-β-d-glucopyranoside against coxsackie virus B3[J]. Biological and Pharmaceutical Bulletin, 2009, 32(1): 68-73.

[3] [3] RYU M, KIM E H, CHUN M, et al. Astragali radix elicits anti-inflammation via activation of MKP-1, concomitant with attenuation of p38 and erk[J]. Journal of Ethnopharmacology, 2008, 115(2): 184-193.

[4] [4] CHAN J Y W, LAM F C, LEUNG P C, et al. Antihypergly- cemic and antioxidative effects of a herbal formulation of Radix astragali, Radix codonopsis and Cortex lycii in a mouse model of type 2 diabetes mellitus[J]. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives, 2009, 23(5): 658-665.

[7] [7] HARMS M, SEALE P. Brown and beige fat: development, fun- ction and therapeutic potential[J]. Nature Medicine, 2013, 19(10): 1252-1263.

[8] [8] BARTELT A, BRUNS O T, REIMER R, et al. Brown adipose tissue activity controls triglyceride clearance[J]. Nature Medicine, 2011, 17(2): 200-205.

[9] [9] YONESHIRO T, WANG Q, TAJIMA K, et al. BCAA cata- bolism in brown fat controls energy homeostasis through SLC25A44[J]. Nature, 2019, 572(7771): 614-619.

[10] [10] SEALE P, KAJIMURA S, SPIEGELMAN B M. Transcriptional control of brown adipocyte development and physiological function-of mice and men[J]. Genes & Development, 2009, 23(7): 788-797.

[11] [11] XIE C, YUAN J, LI H, et al. NONCODEv4: exploring the world of long non-coding RNA genes[J]. Nucleic Acids Research, 2013, 42(D1): D98-D103.

[12] [12] FATICA A, BOZZONI I. Long non-coding RNAs: new players in cell differentiation and development[J]. Nature Reviews Genetics, 2014, 15(1): 7-21.

[13] [13] XU B, GERIN I, MIAO H, et al. Multiple roles for the non-coding RNA SRA in regulation of adipogenesis and insulin sensitivity[J]. PLoS One, 2010, 5(12): e14199.

[14] [14] SUN L, GOFF L A, TRAPNELL C, et al. Long noncoding RNAs regulate adipogenesis[J]. Proceedings of the National Academy of Sciences, 2013, 110(9): 3387-3392.

[15] [15] ZHAO X Y, LI S, WANG G X, et al. A long noncoding RNA transcriptional regulatory circuit drives thermogenic adi- pocyte differentiation[J]. Molecular Cell, 2014, 55(3): 372-382.

[16] [16] ALVAREZ-DOMINGUEZ J R, BAI Z, XU D, et al. De novo reconstruction of adipose tissue transcriptomes reveals long non-coding RNA regulators of brown adipocyte development[J]. Cell Metabolism, 2015, 21(5): 764-776.

[17] [17] LANGMEAD B, SALZBERG S L. Fast gapped-read alignment with bowtie 2[J]. Nature Methods, 2012, 9(4): 357-359.

[18] [18] KIM D, PERTEA G, TRAPNELL C, et al. Tophat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions[J]. Genome Biology, 2013, 14(4): R36-49.

[19] [19] TRAPNELL C, ROBERTS A, GOFF L, et al. Differential gene and transcript expression analysis of RNA-seq experiments with tophat and cufflinks[J]. Nature Protocols, 2012, 7(3): 562-578.

[20] [20] TRAPNELL C, WILLIAMS B A, PERTEA G, et al. Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation[J]. Nature Biotechnology, 2010, 28(5): 511-515.

[21] [21] ROBERTS A, PIMENTEL H, TRAPNELL C, et al. Identification of novel transcripts in annotated genomes using RNA- Seq[J]. Bioinformatics, 2011, 27(17): 2325-2329.

[22] [22] KANEHISA M, ARAKI M, GOTO S, et al. KEGG for linking genomes to life and the environment[J]. Nucleic Acids Re- search, 2008, 36: 480-484.

[23] [23] POWELL T M, KHERA A. Therapeutic approaches to obesity[J]. Current Treatment Options in Cardiovascular Medi- cine, 2010, 12(4): 381-395.

[24] [24] ISHIBASHI J, SEALE P. Beige can be slimming[J]. Science, 2010, 328(5982): 1113-1114.

[25] [25] LEE J H, PARK A, OH K J, et al. The role of adipose tissue mitochondria: regulation of mitochondrial function for the treatment of metabolic diseases[J]. International Journal of Molecular Sciences, 2019, 20(19): 4924-4946.

[26] [26] STANFORD K I, MIDDELBEEK R J, TOWNSEND K L, et al. Brown adipose tissue regulates glucose homeostasis and insulin sensitivity[J]. The Journal of Clinical Investigation, 2012, 123(1): 215-223.

[27] [27] WANG Z, GERSTEIN M, SNYDER M. RNA-Seq: a revolutionary tool for transcriptomics[J]. Nature Reviews Genetics, 2009, 10(1): 57-63.

[28] [28] BILLEREY C, BOUSSAHA M, ESQUERR D, et al. Identification of large intergenic non-coding RNAs in bovine muscle using next-generation transcriptomic sequencing[J]. BMC Genomics, 2014, 15(1): 499-509.

[29] [29] WANG L, YANG X, ZHU Y, et al. Genome-wide identification and characterization of long noncoding RNAs of brown to white adipose tissue transformation in goats[J]. Cells, 2019, 8(8): 904-917.

[30] [30] REN G J, FAN X C, LIU T L, et al. Genome-wide analysis of differentially expressed profiles of mRNAs, lncRNAs and circRNAs during Cryptosporidium baileyi infection[J]. BMC Genomics, 2018, 19(1): 356-371.

[31] [31] MCALLEN R M, TANAKA M, OOTSUKA Y, et al. Multiple thermoregulatory effectors with independent central controls[J]. European Journal of Applied Physiology, 2010, 109(1): 27-33.

[33] [33] ENRIORI P J, SINNAYAH P, SIMONDS S E, et al. Leptin action in the dorsomedial hypothalamus increases sympathetic tone to brown adipose tissue in spite of systemic leptin resis- tance[J]. Journal of Neuroscience, 2011, 31(34): 12189-12197.

[34] [34] PESSIN J E, SALTIEL A R. Signaling pathways in insulin action: molecular targets of insulin resistance[J]. The Journal of Clinical Investigation, 2000, 106(2): 165-169.

[35] [35] DESJARDINS E M, STEINBERG G R. Emerging role of AMPK in brown and beige adipose tissue (BAT): implica- tions for obesity, insulin resistance, and type 2 diabetes[J]. Current Diabetes Reports, 2018, 18(10): 80-89.

[37] [37] KAWAMURA M, JENSEN D F, WANCEWICZ E V, et al. Hormone-sensitive lipase in differentiated 3T3-L1 cells and its activation by cyclic AMP-dependent protein kinase[J]. Proceedings of the National Academy of Sciences, 1981, 78(2): 732-736.

[38] [38] MANGANIELLO V C, MURATA T, TAIRA M, et al. Diversity in cyclic nucleotide phosphodiesterase isoenzyme fa- milies[J]. Archives of Biochemistry & Biophysics, 1995, 322(1): 1-13.

[40] [40] CANTWELL M T, FARRAR J S, LOWNIK J C, et al. STAT3 suppresses Wnt/β-catenin signaling during the induction phase of primary Myf5+ brown adipogenesis[J]. Cytokine, 2018, 111: 434-444.

[41] [41] LAI W S, STUMPO D J, WELLS M L, et al. Importance of the conserved carboxyl-terminal CNOT1 binding domain to tristetraprolin activity in vivo[J]. Molecular and Cellular Biology, 2019, 39(13): e00029-19.

[42] [42] LIN N Y, LIN T Y, YANG W H, et al. Differential expression and functional analysis of the tristetraprolin family during early differentiation of 3T3-L1 preadipocytes[J]. International Journal of Biological Sciences, 2012, 8(5): 761-777.

[43] [43] BOUCHARD L, TCHERNOF A, DESHAIES Y, et al. ZFP36: a promising candidate gene for obesity-related metabolic complications identified by converging genomics[J]. Obesity Surgery, 2007, 17(3): 372-382.

[44] [44] SUN L, STOECKLIN G, VAN WAY S, et al. Tristetraprolin (TTP)-14-3-3 complex formation protects TTP from dephosphorylation by protein phosphatase 2a and stabilizes tumor necrosis factor-α mRNA[J]. Journal of Biological Chemistry, 282(6): 3766-3777.