Chinese Journal of Lasers, Volume. 49, Issue 5, 0507401(2022)

Effects of Phototherapy on Learning Memory and BDNF-TrkB Signaling Pathway in Sleep-Deprived Mice

Hongli Chen1,2, Jingjing Gao2, Zhongdi Jiang2, Zhongpeng Wang1、*, Long Chen1, and Dong Ming1
Author Affiliations
  • 1Academy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin 300072, China
  • 2School of Life Sciences, Tiangong University, Tianjin 300387, China
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    Conclusions

    In this study, we investigated the effects of phototherapy on the learning and memory abilities of sleep-deprived mice by establishing a sleep deprivation model. We discovered that sleep deprivation significantly decreased the learning and memory abilities of mice and produced anxiety-like behaviors, while the combination of 468 nm blue light treatment prevented the increase of inflammatory response, improved the antioxidant capacity of hippocampal tissue, regulated the expression of BDNF-TrkB signaling pathway genes, enhanced inter-synaptic transmission, and effectively improved the learning and memory abilities of mice.

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    Hongli Chen, Jingjing Gao, Zhongdi Jiang, Zhongpeng Wang, Long Chen, Dong Ming. Effects of Phototherapy on Learning Memory and BDNF-TrkB Signaling Pathway in Sleep-Deprived Mice[J]. Chinese Journal of Lasers, 2022, 49(5): 0507401

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    Paper Information

    Received: Nov. 2, 2021

    Accepted: Dec. 29, 2021

    Published Online: Mar. 9, 2022

    The Author Email: Zhongpeng Wang (tunerl_wzp1@tju.edu.cn)

    DOI:10.3788/CJL202249.0507401

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