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Chinese Journal of Lasers, Volume. 48, Issue 15, 1507003(2021)

Advances on in vivo High-Spatial-Resolution Neural Manipulation Based on Optogenetics

Lingjie Kong1,2、*, Cheng Jin1, and Guofan Jin1
Author Affiliations
  • 1State Key Laboratory of Precision Measurement Technology and Instruments, Department of Precision Instrument, Tsinghua University, Beijing 100084, China
  • 2IDG/Mc Govern Institute for Brain Research at Tsinghua, Beijing 100084, China
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    AbstractGet PDF(in Chinese)
    Figures&Tables (5)
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    References (78)
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    Figures & Tables(5)
    Serial excitation with spiral scanning[41]. (a) Principle diagram; (b) optical path

    Fig. 1. Serial excitation with spiral scanning[41]. (a) Principle diagram; (b) optical path

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    Serial excitation with extended pattern. (a) Principle diagram; (b) optical path

    Fig. 2. Serial excitation with extended pattern. (a) Principle diagram; (b) optical path

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    Pattern generation methods based on parallel excitation. (a) Schematic of parallel scanning excitation; (b) optical path for intensity modulation; (c) optical path of GPC; (d) optical path of CGH

    Fig. 3. Pattern generation methods based on parallel excitation. (a) Schematic of parallel scanning excitation; (b) optical path for intensity modulation; (c) optical path of GPC; (d) optical path of CGH

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    Block diagrams of CGH algorithms. (a) GS algorithm; (b) NOVO algorithm; (c) DeepCGH algorithm

    Fig. 4. Block diagrams of CGH algorithms. (a) GS algorithm; (b) NOVO algorithm; (c) DeepCGH algorithm

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    • Table 1. Comparison among in vivo high-spatial-resolution neural manipulation techniques

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      Table 1. Comparison among in vivo high-spatial-resolution neural manipulation techniques

      TechniqueCore componentAdvantageDisadvantage
      Serial excitation with spiral scanning[9-11]Galvanometric mirrorSingle cell accuracy and high power efficiencyLow time resolution andonly being compatiblewith slow turn-off opsins
      Serial excitation with extended pattern[12]Galvanometric mirror andgratingSingle cell accuracy andhigh power efficiencyLow time resolution
      Parallel illumination by GPC based phase modulation [45]SLM and PCFHigh time resolution, high pattern uniformity , matching targetmorphology, and single cell accuracy (with temporal focusing)Low power efficiencyand power subdividedamong targets
      Multi-foci generation based on CGH withspiral scanning[56]SLM and galvanometric mirrorSingle cell accuracy and high powerefficiencyOnly being compatiblewith slow turn-off opsins
      Parallel illumination with extended patterngenerated by CGH[59-60] SLMHigh time resolution, matching target morphology, and single cell accuracy(with temporal focusing)Power subdivided amongtargets and low patternuniformity
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    Lingjie Kong, Cheng Jin, Guofan Jin. Advances on in vivo High-Spatial-Resolution Neural Manipulation Based on Optogenetics[J]. Chinese Journal of Lasers, 2021, 48(15): 1507003

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    Paper Information

    Category: biomedical photonics and laser medicine

    Received: Mar. 16, 2021

    Accepted: Jun. 2, 2021

    Published Online: Aug. 5, 2021

    The Author Email: Lingjie Kong (konglj@tsinghua.edu.cn)

    DOI:10.3788/CJL202148.1507003

    Topics

    laser devices and laser physics
    Lasers and Laser Optics
    Laser physics
    laser manufacturing
    Instrumentation, Measurement and Metrology