Fig. 1. Diagram of BPD structure of liposome

Fig. 2. Different aggregation states of Aβ solution. (a) Aβ fibers; (b) Aβ spherulites; (c) Aβ plaques

Fig. 3. Absorption and fluorescence emission spectra of BPD solution with different mass concentrations. (a) BPD ultraviolet absorption spectra; (b) standard curve of BPD absorbance varying with mass concentration; (c) BPD fluorescence emission spectra; (d) standard curve of BPD fluorescence intensity varying with mass concentration

Fig. 4. Degradation mechanism of Aβ aggregates by BPD and its liposomes

Fig. 5. Degradation results of Aβ plaques with only irradiation. (a)(e) Bright field images; (b)(f) confocal images; (c)(g) second harmonic generation images; (d)(h) two photon excited fluorescence images

Fig. 6. Degradation results of Aβ plaques after irradiation when the concentration of BPD is 1 μmol/L. (a)(e) Bright field images; (b)(f) confocal images; (c)(g) second harmonic generation images; (d)(h) two photon excited fluorescence images

Fig. 7. Degradation results of Aβ plaques after irradiation when the concentration of BPD is 10 μmol/L. (a)(e)(i)(m) Bright field images; (b)(f)(j)(n) confocal images; (c)(g)(k)(o) second harmonic generation images; (d)(h)(l)(p) two photon excited fluorescence images

Fig. 8. Relationship between fluorescence intensity of Aβ plaques and irradiation time

Fig. 9. Degradation results of Aβ plaques after irradiation when the concentration of BPD is 100 μmol/L. (a)(e) Bright field images; (b)(f) confocal images; (c)(g) second harmonic generation images; (d)(h) two photon excited fluorescence images

Fig. 10. Relationship between degradation efficiency of Aβplaques and concentration of BPD

Fig. 11. ELISA detection results of Aβ content after irradiation with different doses

Fig. 12. Degradation results of Aβ plaques after irradiation with BPD liposome. (a)(e) Bright field images; (b)(f) confocal images; (c)(g) second harmonic generation images; (d)(h) two photon excited fluorescence images