Real-time monitoring of hydrogel phase transition in an ultrahigh <i>Q</i> microbubble resonator

Daquan Yang; Aiqiang Wang; Jin-Hui Chen; Xiao-Chong Yu; Chuwen Lan; Yuefeng Ji; Yun-Feng Xiao

doi:10.1364/PRJ.380238

Photonics Research, Volume. 8, Issue 4, 497(2020)

Real-time monitoring of hydrogel phase transition in an ultrahigh Q microbubble resonator

Daquan Yang¹, Aiqiang Wang¹, Jin-Hui Chen², Xiao-Chong Yu², Chuwen Lan¹, Yuefeng Ji¹, and Yun-Feng Xiao^2,3,4,5、*

¹State Key Laboratory of Information Photonics and Optical Communications, School of Information and Communication Engineering, Beijing University of Posts and Telecommunications, Beijing 100876, China

²State Key Laboratory for Artificial Microstructure and Mesoscopic Physics, School of Physics, Peking University, Beijing 100871, China

³Frontiers Science Center for Nano-optoelectronics & Collaborative Innovation Center of Quantum Matter, Beijing 100871, China

⁴Collaborative Innovation Center of Extreme Optics, Shanxi University, Taiyuan 030006, China

⁵Beijing Academy of Quantum Information Sciences, Beijing 100193, China

show less

References(57)

[1] A. Onuki. Phase Transition Dynamics(2002).

[2] K. Kadau, T. C. Germann, P. S. Lomdahl, B. Holian. Microscopic view of structural phase transitions induced by shock waves. Science, 296, 1681-1684(2002).

[3] A. Cavalleri, C. Toth, C. W. Siders, J. A. Squier, F. Raksi, P. Forget, J. C. Kieffer. Femtosecond structural dynamics in VO₂ during an ultrafast solid-solid phase transition. Phys. Rev. Lett., 87, 237401(2001).

[4] G. W. Ashley, J. Henise, R. Reid, D. V. Santi. Hydrogel drug delivery system with predictable and tunable drug release and degradation rates. Proc. Natl. Acad. Sci. USA, 110, 2318-2323(2013).

[5] S. P. Zustiak, J. B. Leach. Characterization of protein release from hydrolytically degradable poly(ethylene glycol) hydrogels. Biotechnol. Bioeng., 108, 197-206(2011).

[6] F. Ordikhani, S. P. Zustiak, A. Simchi. Surface modifications of titanium implants by multilayer bioactive coatings with drug delivery potential: antimicrobial, biological, and drug release studies. J. Miner. Met. Mater. Soc., 68, 1100-1108(2016).

[7] M. Dompé, F. J. Cedano-Serrano, O. Heckert, N. van den Heuvel, J. van der Gucht, Y. Tran, D. Hourdet, C. Creton, M. Kamperman. Thermoresponsive complex coacervate-based underwater adhesive. Adv. Mater., 31, 1808179(2019).

[8] A. M. Mathur, A. B. Scranton. Characterization of hydrogels using nuclear magnetic resonance spectroscopy. Biomaterials, 17, 547-557(1996).

[9] K. M. Schultz, A. D. Baldwin, K. L. Kiick, E. M. Furst. Gelation of covalently cross-linked PEG-heparin hydrogels. Macromolecules, 42, 5310-5316(2009).

[10] K. J. Vahala. Optical microcavities. Nature, 424, 839-846(2003).

[11] E. Betzig, R. J. Chichester. Single molecules observed by near-field scanning optical microscopy. Science, 262, 1422-1425(1993).

[12] X. Fan, I. M. White, S. I. Shopova, H. Zhu, J. D. Suter, Y. Sun. Sensitive optical biosensors for unlabeled targets: a review. Anal. Chim. Acta., 620, 8-26(2008).

[13] Y. Zhi, X.-C. Yu, Q. Gong, L. Yang, Y.-F. Xiao. Single nanoparticle detection using optical microcavities. Adv. Mater., 29, 1604920(2017).

[14] H. Li, Y. Huang, G. Hou, A. Xiao, P. Chen, H. Liang, Y. Huang, X. Zhao, L. Liang, X. Feng, B. Guan. Single-molecule detection of biomarker and localized cellular photothermal therapy using an optical microfiber with nanointerface. Sci. Adv., 5, eaax4659(2019).

[15] S. Frustaci, F. Vollmer. Whispering-gallery mode (WGM) sensors: review of established and WGM-based techniques to study protein conformational dynamics. Curr. Opin. Chem. Biol., 51, 66-73(2019).

[16] F. Vollmer, L. Yang. Review label-free detection with high-Q microcavities: a review of biosensing mechanisms for integrated devices. Nanophotonics, 1, 267-291(2012).

[17] J. D. Swaim, J. Knittel, W. P. Bowen. Detection of nanoparticles with a frequency locked whispering gallery mode microresonator. Appl. Phys. Lett., 102, 183106(2013).

[18] W. J. Chen, S. K. Ozdemir, G. M. Zhao, J. Wiersig, L. Yang. Exceptional points enhance sensing in an optical microcavity. Nature, 548, 192-196(2017).

[19] S. Q. Liu, B. J. Shi, Y. Wang, L. G. Cui, J. Yang, W. M. Sun, H. Y. Li. Whispering gallery modes in a liquid-filled hollow glass microsphere. Opt. Lett., 42, 4659-4662(2017).

[20] J. Zhu, S. K. Ozdemir, Y.-F. Xiao, L. Li, L. He, D.-R. Chen, L. Yang. On-chip single nanoparticle detection and sizing by mode splitting in an ultrahigh-Q microresonator. Nat. Photonics, 4, 46-49(2010).

[21] T. Lu, H. Lee, T. Chen, S. Herchak, J.-H. Kim, S. E. Fraser, R. C. Flagan, K. Vahala. High sensitivity nanoparticle detection using optical microcavities. Proc. Natl. Acad. Sci. USA, 108, 5976-5979(2011).

[22] L. Shao, X. F. Jiang, X.-C. Yu, B.-B. Li, W. R. Clements, F. Vollmer, W. Wang, Y.-F. Xiao, Q. Gong. Detection of single nanoparticles and lentiviruses using microcavity resonance broadening. Adv. Mater., 25, 5616-5620(2013).

[23] B.-B. Li, W. R. Clements, X.-C. Yu, K. Shi, Q. Gong, Y.-F. Xiao. Single nanoparticle detection using split-mode microcavity Raman lasers. Proc. Natl. Acad. Sci. USA, 111, 14657-14662(2014).

[24] S. K. Ozdemir, J. Zhu, X. Yang, B. Peng, H. Yilmaz, L. He, F. Monifi, S. H. Huang, G. L. Long, L. Yang. Highly sensitive detection of nanoparticles with a self-referenced and self-heterodyned whispering-gallery Raman microlaser. Proc. Natl. Acad. Sci. USA, 111, E3836-E3844(2014).

[25] K. D. Heylman, N. Thakkar, E. H. Horak, S. C. Quillin, C. Cherqui, K. A. Knapper, D. J. Masiello, R. H. Goldsmith. Optical microresonators as single-particle absorption spectrometers. Nat. Photonics, 10, 788-795(2016).

[26] J. Su, A. F. Goldberg, B. M. Stoltz. Label-free detection of single nanoparticles and biological molecules using microtoroid optical resonators. Light Sci. Appl., 5, e16001(2016).

[27] X.-C. Yu, Y. Zhi, S.-J. Tang, B.-B. Li, Q. Gong, C.-W. Qiu, Y.-F. Xiao. Optically sizing single atmospheric particulates with a 10-nm resolution using a strong evanescent field. Light Sci. Appl., 7, 18003(2018).

[28] X.-C. Yu, B.-B. Li, P. Wang, L. Tong, X.-F. Jiang, Y. Li, Q. Gong, Y.-F. Xiao. Single nanoparticle detection and sizing using a nanofiber pair in aqueous environment. Adv. Mater., 26, 7462-7467(2014).

[29] N. Zhang, Z. Gu, S. Liu, Y. Wang, S. Wang, Z. Duan, W. Sun, Y.-F. Xiao, S. Xiao, Q. Song. Far-field single nanoparticle detection and sizing. Optica, 4, 1151-1156(2017).

[30] S.-J. Tang, S. Liu, X.-C. Yu, Q. Song, Q. Gong, Y.-F. Xiao. On-chip spiral waveguides for ultrasensitive and rapid detection of nanoscale objects. Adv. Mater., 30, 1800262(2018).

[31] J. M. Ward, Y. Yang, F. Lei, X.-C. Yu, Y.-F. Xiao, S. N. Chormaic. Nanoparticle sensing beyond evanescent field interaction with a quasi-droplet microcavity. Optica, 5, 674-677(2018).

[32] H. Jing, H. Lü, S. K. Ozdemir, T. Carmon, F. Nori. Nanoparticle sensing with a spinning resonator. Optica, 5, 1424-1430(2018).

[33] M. R. Foreman, D. Keng, E. Treasurer, J. R. Lopez, S. Arnold. Whispering gallery mode single nanoparticle detection and sizing: the validity of the dipole approximation. Opt. Lett., 42, 963-966(2017).

[34] F. Vollmer, S. Arnold. Whispering-gallery-mode biosensing: label-free detection down to single molecules. Nat. Methods, 5, 591-596(2008).

[35] F. Vollmer, S. Arnold, D. Keng. Single virus detection from the reactive shift of a whispering-gallery mode. Proc. Natl. Acad. Sci. USA, 105, 20701-20704(2008).

[36] L. He, S. K. Ozdemir, J. Zhu, W. Kim, L. Yang. Detecting single viruses and nanoparticles using whispering gallery microlasers. Nat. Nanotechnol., 6, 428-432(2011).

[37] I. Ament, J. Prasad, A. Henkel, S. Schmachtel, C. Sonnichsen. Single unlabeled protein detection on individual plasmonic nanoparticles. Nano Lett., 12, 1092-1095(2012).

[38] V. R. Dantham, S. Holler, C. Barbre, D. Keng, V. Kolchenko, S. Arnold. Label-free detection of single protein using a nanoplasmonic-photonic hybrid microcavity. Nano Lett., 13, 3347-3351(2013).

[39] M. D. Baaske, M. R. Foreman, F. Vollmer. Single-molecule nucleic acid interactions monitored on a label-free microcavity biosensor platform. Nat. Nanotechnol., 9, 933-939(2014).

[40] J. Su. Label-free single exosome detection using frequency-locked microtoroid optical resonators. ACS Photon., 2, 1241-1245(2015).

[41] E. Kim, M. D. Baaske, F. Vollmer. In situ observation of single-molecule surface reactions from low to high affinities. Adv. Mater., 28, 9941-9948(2016).

[42] W. Yu, W. C. Jiang, Q. Lin, T. Lu. Cavity optomechanical spring sensing of single molecules. Nat. Commun., 7, 12311(2016).

[43] S. Subramanian, H.-Y. Wu, T. Constant, J. Xavier, F. Vollmer. Label-free optical single-molecule micro-and nanosensors. Adv. Mater., 30, 1801246(2018).

[44] E. Kim, M. D. Baaske, I. Schuldes, P. S. Wilsch, F. Vollmer. Label-free optical detection of single enzyme-reactant reactions and associated conformational changes. Sci. Adv., 3, e1603044(2017).

[45] Z. Li, C. Zhu, Z. Guo, B. Wang, X. Wu, Y. Fei. Highly sensitive label-free detection of small molecules with an optofluidic microbubble resonator. Micromachines, 9, 274(2018).

[46] Y. Zhang, T. Zhou, B. Han, A. Zhang, Y. Zhao. Optical bio-chemical sensors based on whispering gallery mode resonators. Nanoscale, 10, 13832-13856(2018).

[47] M. D. Baaske, F. Vollmer. Optical observation of single atomic ions interacting with plasmonic nanorods in aqueous solution. Nat. Photonics, 10, 733-739(2016).

[48] S. H. Huang, S. Sheth, E. Jain, X. Jiang, S. P. Zustiak, L. Yang. Whispering gallery mode resonator sensor for in situ measurements of hydrogel gelation. Opt. Express, 26, 51-62(2018).

[49] H. G. Schild. Poly(N-isopropylacrylamide): experiment, theory and application. Prog. Polym. Sci., 17, 163-249(1992).

[50] B. Jeong, S. W. Kim, Y. H. Bae. Thermosensitive sol-gel reversible hydrogels. Adv. Drug Delivery Rev., 64, 154-162(2012).

[51] M. Xiong, B. Gu, J.-D. Zhang, J.-J. Xu, H.-Y. Chen, H. Zhong. Glucose microfluidic biosensors based on reversible enzyme immobilization on photopatterned stimuli-responsive polymer. Biosens. Bioelectron., 50, 229-234(2013).

[52] Y. Zhou, Y. Cai, X. Hu, Y. Long. Temperature-responsive hydrogel with ultra-large solar modulation and high luminous transmission for smart window applications. J. Mater. Chem. A, 2, 13550-13555(2014).

[53] Y. Ding, X. Ye, G. Zhang. Microcalorimetric investigation on aggregation and dissolution of poly(N-isopropylacrylamide) chains in water. Macromolecules, 38, 904-908(2005).

[54] H. Cheng, L. Shen, C. Wu. LLS and FTIR studies on the hysteresis in association and dissociation of poly(N-isopropylacrylamide) chains in water. Macromolecules, 39, 2325-2329(2006).

[55] G. Graziano. On the temperature-induced coil to globule transition of poly-N-isopropylacrylamide in dilute aqueous solutions. Int. J. Biol. Macromol., 27, 89-97(2000).

[56] A. Burmistrova, M. Richter, M. Eisele, C. Üzüm, R. Von Klitzing. The effect of co-monomer content on the swelling/shrinking and mechanical behaviour of individually adsorbed PNIPAM microgel particles. Polymers, 3, 1575-1590(2011).

[57] S. Cai, Z. Suo. Mechanics and chemical thermodynamics of phase transition in temperature-sensitive hydrogels. J. Mech. Phys. Solids, 59, 2259-2278(2011).

CLP Journals

[1] Daquan Yang, Xiao Liu, Xiaogang Li, Bing Duan, Aiqiang Wang, Yunfeng Xiao. Photoic crystal nanobeam cavity devices for on-chip integrated silicon photonics[J]. Journal of Semiconductors, 2021, 42(2): 023103

[2] Zijie Wang, Xiaobei Zhang, Qi Zhang, Yiqi Chen, Yong Yang, Yang Yu, Yang Wang, Yanhua Dong, Yi Huang, Tingyun Wang, "Monitoring and identifying pendant droplets in microbottle resonators," Photonics Res. 10, 662 (2022)

Tools

Get Citation

Copy Citation Text

Daquan Yang, Aiqiang Wang, Jin-Hui Chen, Xiao-Chong Yu, Chuwen Lan, Yuefeng Ji, Yun-Feng Xiao, "Real-time monitoring of hydrogel phase transition in an ultrahigh Q microbubble resonator," Photonics Res. 8, 497 (2020)

Download Citation

EndNote(RIS)BibTex Plain Text

Set citation alerts for article

Save article for my favorites

Paper Information

Category: Optical Devices

Received: Oct. 15, 2019

Accepted: Jan. 21, 2020

Published Online: Mar. 19, 2020

The Author Email: Yun-Feng Xiao (yfxiao@pku.edu.cn)

DOI:10.1364/PRJ.380238

Topics

laser devices and laser physics

Lasers and Laser Optics

Laser physics

laser manufacturing

Instrumentation, Measurement and Metrology